Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/10515
標題: Chitosan/磷酸鈣鹽複合材料微球之製備與特性分析
Preparation and characterization of chitosan/calcium phosphate composite microspheres
作者: 黃士瑋
Huang, Shih-Wei
關鍵字: chitosan
甲殼素
hydroxyapatite
calcium phosphate
microsphere
氫氧基磷灰石
磷酸鈣鹽
微球
出版社: 材料科學與工程學系所
引用: 1. Kose GT, Korkusuz F, Ozkul A, Soysal Y, Ozdemir T, Yildiz C, Hasirci V. Tissue engineered cartilage on collagen and PHBV matrices. Biomaterials 2005;26(25):5187-97. 2. Mehrdad Hamidi, Amir Azadi, Pedram Rafiei. Hydrogel nanoparticles in drug delivery. Advanced Drug Delivery Reviews 60 (2008) 1638-1649. 3. Dimitiro F. Stamatialis, Bernke J. Papenburg, Miriam Girones, Saiful Saiful, Srivatsa N.M. Bettahalli, Stephanie Schmitmeier and Matthias Wessling. Medical applications of membranes: Drug delivery, artificial organs and tissue engineering. Journal of Membrane Science 308 (2008) 1-34. 4. Masuko T, Iwasaki N, Yamane S, Funakoshi T, Majima T, Minami A, Ohsuga N, Ohta T, Nishimura S. Chitosan-RGDSGGC conjugate as a scaffold material for musculoskeletal tissue engineering. Biomaterials (2005);26(26):5339-47. 5. Hoemann CD, Sun J, Legare A, McKee MD, Buschmann MD. Tissue engineering of cartilage using an injectable and adhesive chitosan-based cell-delivery vehicle. Osteoarthritis and cartilage(2005);13(4):318-29 6. H. Zhang, I.A. Alsarra, S.H. Neau, An in vitro evaluation of a chitosan-containing multiparticulate system for macromolecule delivery to the colon, Int. J. Pharm. 239 (2002) 197-205. 7. S. Nsereko, M. Amiji, Localized delivery of paclitaxel in solid tumors from biodegradable chitin microparticle formulations, Biomaterials 23 (2002) 2723-2731. 8. X.Y. Shi, T.W. Tan, Preparation of chitosan/ethylcellulose complex microcapsule and its application in controlled release of vitamin D2, Biomaterials 23 (2002) 4469-4473. 9. Min Lang Tsai, Shi Wei Bai, Rong Huei Chen. Cavitation effects versus stretch effects resulted in different size and polydispersity of ionotropic gelation chitosan-sodium tripolyphosphate nanoparticle. Carbohydrate Polymers 71 (2008) 448-457. 10. M.A. Bayomi, S.A. Al-Suwayeh, A.M. El-Helw, A.F. Mesnad. Preparation of casein-chitosan microspheres containing diltiazem hydrochloride by an aqueous coacervation technique. Pharmaceutica Acta Helvetiae 73 (1998) 187-192 11. Wei Wei, Lian-Yan Wang, Lan Yuan, Xiao-Da Yang, Zhi-Guo Su, Guang-Hui Ma," Bioprocess of uniform-sized crosslinked chitosan microspheres in rats following oral administration" European Journal of Pharmaceutics and Biopharmaceutics 69 (2008) 878-886 12. Habraken WJEM, Wolke JGC, Jansen JA. Adv Drug Deliv Rev (2007);59:234-48. 13. Sergey V. Dorozhkin and Matthisa Epple “Biological and medical significance of calcium phosphates” Angew. Chem. Int. Ed. 41,3130-3146. (2002) 14. H. Hattori, Y. Iwadate, “Hydrothermal preparation of calcium hydroxyapatite powders”, J. Am. Ceram. Soc.,73,(1990), p.1803-1805. 15. Sumit Pramanik, Avinash Kumar Agaral, K.N Rai and Ashish Garg, “Delvelopment of high strength hydroxyapatite by solid-state-sintering process”, Ceramics International, In Press Corrected Proof, (2006). 16. Wang Feng, Li Mu-sen, Lu Yu-peng and Qi Yong-Xin, “A simple sol-gel technique for preparing hydroxyapatite nanopowders," Materials Letter, 59, (2005), p.916-919." 17. L. Bernard, M. Freche, J.L. Lacout and B. Biscans, “Preparation of hydroxyapatite by neutrazation at low temperature-influence of purity of the raw material”, Powder Technol. 103, (1999), p.19 18. Fukue Nagate, Tatsuya Miyajima and Yoshiyuki Yokogawa, “A method to fabricate hydroxyapatite/poly(latic acid) microspheres intended for biomedical application”, Journal of the European Ceramic Society, 26, (2006), p.533-535. 19. A. Sinha A T. Mishra A N. Ravishankar,” Polymer assisted hydroxyapatite microspheres suitable for biomedical application”, J Mater Sci:Mater Med DOI 10.1007/s10856-007-3286-0 20. Zhang-Qi Feng ,Xuehui Chu , Ning-Ping Huang, Tao Wang ,Yichun Wang, Xiaolei Shi, Yitao Ding, Zhong-Ze Gu, “The effect of nanofibrous galactosylated chitosan scaffolds on the formation of rat primary hepatocyte aggregates and the maintenance of liver function”, Biomaterials 30 (2009) 2753-2763 21. Hu Q, Li B, Wang M, Shen J. Preparation and characterization of biodegradable chitosan/hydroxyapatite nanocomposite rods via in situ hybridization: a potential material as internal fixation of bone fracture. Biomaterials 2004;25(5):779-85. 22. Kong L, Gao Y, Cao W, Gong Y, Zhao N, Zhang X. Preparation and characterization of nano-hydroxyapatite/chitosan composite scaffolds. J Biomed Mater Res 2005;75A:275-82. 23. Rusu VM, Ng CH, Wilke M, Tiersch B, Fratzl P, Peter MG. Sizecontrolled hydroxyapatite nanoparticles as self-organized organic-inorganic composite materials. Biomaterials 2005;26(26):5414-26. 24. K. S. W. Sing, D. H. Evertt, R. A. Hayl, L. Moscou, R. A. Pierotti, J. Rouquerol, and T. Simieniewska. “Reporting physisorption data for gas/solid systems with special reference to the determination of surface area and porosity” Pure & Appl. Chem. 57, 603-619. 1985
摘要: The porous calcium phosphate/chitosan composite microspheres could have been successfully synthesized in Ca(NO3)2‧4H2O, NH4H2PO4, and chitosan cantained aqueous solution by using hydrothermal method. Chitosan could be a chelating agent for the nucleation of CaP. The microstructure and chemical bonding of the microspheres were characterized by using scanning electron microscopy (SEM), X-ray diffractometry (XRD), transmission electron microscopy (TEM), FT-IR spectrometer, and specific surface area/porosimetry & chemisorption analyzer. The porous microphres exhibit a specific surface area 38.16 m2/g, pore size from 4~100nm, and pore volume 0.24 cm3/g. Because this composite microsphere has chitosan character and also has great porosity. They could be considered as drugs or catalysts carriers, and injectable powders of bone graft.
本研究利用水熱法成功的合成了多孔性磷酸鈣/chitosan的複合微球,chitosan會形成一個螯合劑來幫助磷酸鈣鹽成長,而多孔複合微球的結構跟化學鍵則利用掃描式電子顯微鏡、穿透式電子顯微鏡、X射線繞射儀、傅立葉轉換紅外線光譜儀、比表面與孔隙度分析儀、熱重分析儀、熱差分析儀來做分析。分析的結果指出本研究所合成出來的多孔性複合微球具有 38.16 m2/g 的比表面積,孔隙大小由4~100 nm,微孔及介孔比體積為0.24 cm3/g。因本研究所合成出來的多孔性複合微球具有著chitosan的特徵及良好的孔隙度,因此可以做來用藥劑或觸媒的載體,以及可注射骨粉等用途。
URI: http://hdl.handle.net/11455/10515
其他識別: U0005-2208200701473100
文章連結: http://www.airitilibrary.com/Publication/alDetailedMesh1?DocID=U0005-2208200701473100
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