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標題: 微波輔助鐵白金磁性奈米粒子之合成及其物理性質與熱治療之應用研究
Microwave-assisted synthesis and characterization of FePt magnetic nanoparticles for hyperthermia application
作者: 蔡明叡
Tsai, Ming-Jui
關鍵字: microwave
出版社: 材料科學與工程學系所
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摘要: 鐵白金為現今磁性材料的熱門研究物系之一,此物系不僅在磁紀錄儲存媒體的研發上被廣泛的研究,近年來也因為鐵白金具有高居里溫度、高飽和磁化量及高化學安定性等特性被探討及應用在生物醫學治療等生醫領域。 本實驗為使用不同於傳統加熱方式(加熱包);以微波做為加熱源來合成非序化相鐵白金磁性奈米粒子,接著在鐵白金磁性奈米粒子外包覆緻密氧化矽殼層以增進其水溶性,進而增加在生醫方面的應用。 在包覆緻密氧化矽殼層前後進行快速升溫退火(rapid thermal annealing, RTA)處理,探討其性質變化之差異。在包覆緻密氧化矽殼層後,分別在退火前後進行高周波加熱(hyperthermia)的研究及其對細胞之生物毒性之探討。
Iron Platinum (FePt) is one of popular magnetic materials in recent years. FePt not only been studied and used in magnetic data storage device but also investigated its potential application in biomedical field because its high Curie temperature, high saturation magnetization and high chemical stability. In this experiment, we use microwave as a new heating source which different from convential method during the process of synthesis disordered fcc phase FePt magnetic nanoparticles. After FePt nanoparticles has synthesized, SiO2 shell coated on FePt nanoparticles intent to improve their water-soluble ability. We will discuss the difference between annealing FePt nanoparticles by rapid thermal anneal (RTA) befor/after coated SiO2 shell and the difference between FePt coated SiO2 shell nanoparticles used in hyperthermia before/after annealed by rapid thermal anneal (RTA). We also use MTT assay to investigate its cytotoxicity.
Appears in Collections:材料科學與工程學系



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