Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/12822
標題: 以羥四環素控制Q熱導致肉山羊之流產
The Control of Q Fever-induced Abortion by Using Oxytetracycline in Meat Goats
作者: 謝孟純
Hsieh, Meng-Chun
關鍵字: Q fever control
Q熱控制
oxytetracycline
meat goat
abortion
羥四環素
肉山羊
流產
出版社: 獸醫學系暨研究所
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摘要: Q熱為一種人畜共通傳染病,由絕對細胞內寄生的貝氏考克斯菌(Coxiella burnetii)所引起,反芻獸為最主要的保菌動物。造成經濟損失的繁殖障礙問題為受感染的動物的主要臨床表徵,而這些動物可藉由生殖道產物、糞便及乳汁等途徑排菌,人類通常藉由吸入這些受汙染的塵埃感染疾病。普遍來說,山羊被認為是影響人類Q熱流行病學的重要因子之一,而四環素類藥物曾被用來研究有關治療及控制人類及動物的Q熱。因此,本研究目的乃調查在懷孕末期進行羥四環素(Oxytetracycline, OTC)的注射對於控制因Q熱引起流產的效力。本次實驗利用間接免疫螢光分析(indirect immunofluorescence assay, IFA)結果於2牧場中共選取32隻懷孕母山羊並平分成兩個族群,分別是Q熱抗體陽性及抗體陰性組,將各族群中的8隻羊於懷孕滿三個月及滿四個月時各進行一次20 mg/kg羥四環素注射做為實驗組,而其他的16隻對照組羊則不給予任何抗生素。為了排除其他可能致流產原因,本次試驗同時進行流產披衣菌(Chlamydophila abortus)及弓蟲病(Toxoplasma gondii)的檢測。試驗結果顯示實驗組有兩隻羊及對照組中一隻羊發生流產,而實驗組的兩隻流產羊及對照組另一隻正常分娩的羊出現Q熱排菌情形。披衣菌調查結果中,實驗組中有一隻流產羊的陰道拭子樣本及另一隻流產羊的胎兒臟器樣本檢測呈現PCR陽性;而弓蟲調查則未發現PCR陽性樣本。本次的三隻流產母羊中,推測其Q熱抗體陰性且施打OTC的羊可能因披衣菌造成流產;Q熱抗體陽性而有施打OTC的羊可能因Q熱及披衣菌而流產;而Q熱抗體陰性但未施打OTC的羊隻則因其他不明原因導致流產。此外,有三隻對照組的羊隻發生Q熱抗體陰性轉成抗體陽性現象,而實驗組羊隻並未發現抗體轉變現象。在本次研究中,OTC治療並不能有效預防流產發生,但所有的抗體轉變現象都來自對照組族群,顯示OTC可以減少Q熱潛伏性感染的發生。
Q fever is a zoonosis caused by Coxiella burnetii, an obligate intracellular bacterium largely carried by ruminants. Reproductive disorders that are responsible for important economic losses are the main manifestation in infected animals which can shed the organisms by vaginal mucus, birth product, feces, and milk. Humans obtain the infection mainly through the inhalation of contaminated aerosols. In general, goat exposure is significantly associated with seropositivity of Q fever in human, and tetracyclines have been investigated with their effect in Q fever in human and animals. Therefore, the aim of the study was to examine the effect of control Q fever-induced abortion of goats with oxytetracycline (OTC) injection during the late pregnancy. There were 32 pregnant does in two farms divided equally into two groups by seronegative and seropositive results of Q fever by indirect immunofluorescence assay (IFA) test. A double injection with a dose of 20 mg/kg OTC was then administered to the 8 does in each group during the 4th and 5th gestation month as the test group, while other 16 does in control group didn't receive any antibiotic. To exclude other abortifacient agents, the Chlamydophila abortus and Toxoplasma gondii were investigated. The result showed that the two treated does and one untreated doe aborted, otherwise, there were two aborted does in the test group and another untreated doe with normal parturition found to shed the C. burnetii. The PCR result of C. abortus was positive in the vaginal swab sample of one treated doe with abortion and one aborted fetus from the other treated doe, and there was no positive result of PCR to T. gondii. Of the three aborted does, we infered the Q fever seronegative doe with OTC injection might infected with chlamydiosis; the Q fever seropositive doe with OTC injection might infected with Q fever and chlamidiosis; the abortion of the Q fever seronegative doe without OTC injection might other unknown reason. Furthermore, three untreated does but no treated doe revealed seroconversion of Q fever from seronegative to seropositive. In conclusion, the OTC treatment didn't effectively prevent the abortion. However, all the seroconversion of Q fever came from the untreated group, suggesting that the latent Q fever infection could be clinically reduced by the preventive measure.  
URI: http://hdl.handle.net/11455/12822
其他識別: U0005-0607201213150200
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