請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/12830
標題: 台灣中部地區爬蟲類之綠膿桿菌調查
A survey of Pseudomonas aeruginosa isolated from reptiles in central Taiwan
作者: 翁令玲
Weng, Ling-Ling
關鍵字: taiwan
台灣
Pseudomonas aeruginosa
reptile
lizard
snake
stomatitis
snake bite
pfge
antimicrobial susceptibility testing
綠膿桿菌
爬蟲
蜥蜴

口炎
口腔
咬傷
脈衝式電泳
藥物敏感性試驗
出版社: 獸醫學系暨研究所
引用: 1. 毛壽先,殷鳳儀。台灣常見陸地毒蛇簡介。台灣省立博物館出版部。台北市。中華民國。1990。 2. 林哲祺,林素容,朱純燕。獸醫臨床細菌鑑定圖譜。藝軒。台北市。中華民國。1984。 3. 姜秋芬,劉昌邦,王乃玉,李聰明。北部某醫學中心內科加護病房泛抗藥性綠膿桿菌群突發之調查報告。內科學誌,16:84-90,2005。 4. 孫友梅,張紹光。台灣北區人類、家犬與雞中止蛋之綠膿桿菌抗藥性調查。碩士論文。國立台灣大學獸醫學研究所。台北市。中華民國。2008。 5. 陳俊宇。台灣地區爬蟲類寵物沙門氏菌感染之流行病學研究。碩士論文。國立中興大學獸醫公共衛生學研究所。台中市。中華民國。2006。 6. 郭安靜,蘇玲慧,簡春治,賈立成,甯孝真,李佳縉,吳竹蘭。台灣南北兩家醫學中心在 2000年至2007年間之綠膿桿菌抗生素抗藥性演變。J Biomed Lab Sci,31:98-105,2009。 7. 馮介凡,胡芳蓉。微生物感染性角膜潰瘍在台大醫院的現況。碩士論文。國立台灣大學臨床醫學研究所。台北市。中華民國。2005。 8. Atlas RM. Handbook of Microbiological Media 4th ed. Taylor & Francis group, Raton, Mexico, 1438-1447, 2010. 9. Gray CW, Davis J, McCarten WG. Treatment of Pseudomonas infections in the snake and lizard collection of Washington Zoo. In: International Zoo Yearbook Vol. 6, London Zoological Society, London, 278, 1996. 10. Jacobson ER. Bacterial disease of reptile. In: Jacobson ER. Infectious disease and pathology of reptile. Taylor & Francis group, Raton, Mexico, 462-462, 2007. 11. Jacobson ER. Biology and diseases of reptiles, In: Fox JG, Cohen B, Lowe F eds. Laboratory Animal Medicine. Academic Press, New York, 449-476, 1984. 12. Nicas TI, Iglewski BH. Toxins and virulence factors of Pseudomonas aeruginosa. In: Nicas TI, Iglewski BH eds. The Bacteria Vol X. Academic Press, New York, USA, 195-213, 1986. 13. Pare JA, Sigler L, Rosenthal KL, Mader R. Microbiology: fungal and bacterial disease of reptile. In: Mader DR. eds. Reptile Medicine and Surgery. Saunders Elsevier Inc., Philadelphia, USA, 232-235, 927, 2006. 14. Pitt TL, Simpson AJH. Pseudomonas and Burkholderia spp.. In: Gillespie SH, Hawkey PM. eds. Principles and Practice of Clinical Bacteriology 2nd ed. John Wiley & Sons, West Sussex, UK, 427-444, 2006. 15. Quinn PJ, Markey BK, Carter ME, Donnelly WJ, Leonard FC. Pseudomonas and Burkholderia species. In: Quinn PJ, Markey BK, Carter ME, Donnelly WJ, Leonard FC eds. Veterinary Microbiology and Microbial Disease 1st ed. Blackwell, Oxford, UK, 124-125. 2006. 16. Wikler MA, Cockerill FR, Dubley MN, Eliopoulos GM, Hecht DW, Hindler JF, Low DE, Sheehan DJ, Tenover FC, Turnidge JD, Weinstein MP, Zimmer BL, Ferraro MJ, Swenson MJ. Performance standards for antimicrobial susceptibility testing; sixteenth informational supplement. Clinical Laboratory Standard Institute (CLSI), Pennsylvania, USA, 2011. 17. Wikler MA, Cockerill FR, Dubley MN, Eliopoulos GM, Hecht DW, Hindler JF, Low DE, Sheehan DJ, Tenover FC, Turnidge JD, Weinstein MP, Zimmer BL, Ferraro MJ, Swenson MJ. Performance standards for antimicrobial susceptibility testing; twenty-first informational supplement. Clinical Laboratory Standard Institute (CLSI), Pennsylvania, USA, 2006. 18. Woods DE, Vasil ML. Pathogenesis of Pseudomonas aeruginosa infections. In: Baltch AL, Smith RP eds. Pseudomonas aeruginosa Infections and Treatment. Marcel Dekker, New York, USA, 21-50, 1994. 19. World Health Organization: Surveillance standards for antimicrobial resistance. WHO/CDS/CSR/ DRS/2001. 20. Aguilar-Duran S, Horcajada JP, Sorli L, Montero M, Salvado M, Grau S, Gomez J, Knobel H. Community-onset healthcare-related urinary tract infections: Comparison with community and hospital- acquired urinary tract infections. J Infect, 2012. 21. Aleksandrov M, Petkov A. Case of Pseudomonas aeruginosa infection in tropical snakes (Article in Bulgarian). Vet Med Nauki 22:53-61, 1985. 22. Blondeau JM. Fluoroquinolones: mechanism of action, classification and development of resistance. Surv Ophthalmol 49:73-78, 2004. 23. Bonomo RA, Szabo D. Mechanisms of multidrug resistance in Acinetobacter species and Pseudomonas aeruginosa. Clin Infect Dis 43:49-56, 2006. 24. Braoudaki M, Hilton AC. Adaptive resistance to biocides in Salmonella enterica and Escherichia coli O157 and cross-resistance to antimicrobial agents. J Clin Microbiol 42:73-78, 2004. 25. Burke RM, Upton ME, McLoughlin AJ. Influence of pigment production on resistance to ultraviolet irradiation in Pseudomonas aeruginosa. Irish J Food Sci Tech 14:51-60, 1990. 26. Bush K, Jacoby GA, Medeiros AA. A functional classification scheme for beta-lactamases and its correlation with molecular structure. Antimicrob Agents Chemother 39:1211-1233, 1995. 27. Bush K. Characterization of beta-lactamases. Antimicrob Agents Chemother 33:259-263, 1989a. 28. Bush K. Classification of beta-lactamases: groups 2c, 2d, 2e, 3, and 4. Antimicrob Agents Chemother 33:271-276, 1989b. 29. Chen CM, Wu KG, Chen CJ, Wang CM. Bacterial infection in association with snakebite: a 10-year experience in a northern Taiwan medical center. J Microbiol Immunol Inf 44:456-460, 2011. 30. Chuanchuen R, Beinlich K, Hoang TT, Becher A, Karkhoff-Schweizer RR, Schweizer HP. Cross-resistance between triclosan and antibiotics in Pseudomonas aeruginosa is mediated by multidrug efflux pumps: exposure of a susceptible mutant strain to triclosan selects nfxB mutants overexpressing MexCD-OprJ. Antimicrob Agents Chemother 45:428-432, 2001. 31. Colodner R. Extended-spectrum β-lactamases: a challenge for clinical microbiologists and infection control specialists. Am J Infect Control 33:104-107, 2005. 32. Colinon C, Jocktane D, Brothier E, Rossilini GM, Cournoyer B, Nazaret S. Genetic analyses of Pseudomonas aeruginosa isolated from healthy captive snakes: evidence of high inter- and intrasite dissemination and occurrence of antibiotic resistance genes. Environ Microbiol 12: 716-729, 2010. 33. Costerton JW, Stewart PS, Greenberg EP. Bacterial biofilms: a common cause of persistent infections. Science 284:1318-1322, 1999. 34. Cox CD. Role of pyocyanin in the acquisition of iron from transferrin. Infect Immun. 52:263-270, 1986. 35. Daly JA, Boshard R, Matsen JM. Differential primary plating medium for enhancement of pigment production by Pseudomonas aeruginosa. J Clin Microbiol 19:742-743, 1984. 36. Davis BD. Mechanism of bactericidal action of aminoglycosides. Microbiol Rev 51:341-350, 1987. 37. Denton M, Kerr K, Mooney L. Transmission of colistin-resistant Pseudomonas aeruginosa between patients attending a pediatric cystic fibrosis center. Pediatr Pulmonol 34:257-261, 2002. 38. Draper CS, Walker RD, Lawler HE. Patterns of oral bacterial infection in captive snakes. J Am Vet Med Assoc 179:1223-1226, 1981. 39. Drenkard E, Ausubel FM. Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation. Nature 416:740-743, 2002. 40. Ebani VV, Fratini F, Ampola M, Rizzo E, Cerri D, Andreani E. Pseudomonas and Aeromonas isolates from domestic reptiles and study of their antimicrobial in vitro sensitivity. Vet Res Commun 32:195-198, 2008. 41. Feltman H, Schulert G, Khan S, Jain M, Peterson L, Hauser AR. Prevalence of type III secretion genes in clinical and environmental isolates of Pseudomonas aeruginosa. Microbiology 147:2659-2669, 2001. 42. Fluit AC, Visser MR, Schmitz FJ. Molecular detection of antimicrobial resistance. Clin Microbiol Rev 14:836-871, 2001. 43. Fonseca MG, Moreira WMQ, Cunha KC. Oral microbiota of Brazilian captive snake. J Venom Anim Toxins incl Trop Dis 15:54-60, 2009. 44. Fridkin SK, Steward CD, Edwards JR, Pryor ER, McGowan JE Jr, Archibald LK, Gaynes RP, Tenover FC. Surveillance of antimicrobial use and antimicrobial resistance in United States hospitals: project ICARE phase 2. Project Intensive Care Antimicrobial Resistance Epidemiology (ICARE) hospitals. Clin Infect Dis 29: 245-252, 1999. 45. Fujitani S, Sun HY, Yu VL, Weingarten JA. Pneumonia due to Pseudomonas aeruginosa Part I epidemiology, clinical diagnosis and source. Chest 139:909-919, 2011. 46. Goldstein EJ, Agyare EO, Vagvolgyi AE. Aerobic bacterial oral flora of Garter snakes: development of normal flora and pathogenic potential for snakes and humans. J Clin Microbiol 13:954-956, 1981. 47. Gustaferro CA, Steckelberg JM. Cephalosporin antimicrobial agents and related compounds. Mayo Clin Proc 66:1064-1073, 1991. 48. Harada K, Shimizu T, Kataoka Y, Takahashi T. Post-antibiotic effect of orbifloxacin against Escherichia coli and Pseudomonas aeruginosa isolates from dogs. Acta Vet Scand 54:16, 2012. 49. Hanberger H, Erlandsson M, Burman LG, Cars O, Gill H, Lindgren S, Lennart N, Olsson-Liljequist B, Walther SM. High antibiotic susceptibility among bacterial pathogens in Swedish ICUs. Report from a nation-wide surveillance program using TA90 as a novel index of susceptibility. Scan J Infect Dis 36:24-30, 2004. 50. Harada K, Arima S, Niina A, Kataoka Y, Takahashi T. Characterization of Pseudomonas aeruginosa isolates from dogs and cats in Japan: current status of antimicrobial resistance and prevailing resistance mechanisms. Microbiol Immunol 56:123-127, 2012. 51. Hirakawa Y, Sasaki H, Kawamoto E, Ishikawa H, Matsumoto T, Aoyama N, Kawasumi K, Amao H. Prevalence and analysis of Pseudomonas aeruginosa in chinchillas. BMC Vet Res 6:52-62, 2010. 52. Hocquet D, Vogne C, El Garch F, Vejux A, Gotoh N, Lee A, Lomovskaya O, Plesiat P. MexXY-OprM efflux pump is necessary for a adaptive resistance of Pseudomonas aeruginosa to aminoglycoside. Antimicrob Agent Chemother. 47:1371-1375, 2003. 53. Jacobson ER, Origgi F, Pessier AP, Lamirande EW, Walker I, Whitaker B, Stalis IH, Nordhausen R, Owens JW, Nichols DK, Heard D, Homer B. Paramyxovirus infection in caiman lizards, Draecena guianensis. J Vet Diag Investig 13:143-151, 2001. 54. Jacobson ER. Diseases of reptiles Part II. Infectious diseases. Compend Contin Educ Pract Vet 3:195-200, 1981. 55. Jean SS, Hsueh PR. Antimicrobial drug resistance in Taiwan. J Formos Med Assoc 110:4-13. 2011. 56. Jean SS, Hsueh PR, Lee WS, Chang HT, Chou MY, Chen IS, Wang JH, Lin CF, Shyr JM, Ko WC, Wu JJ, Liu YC, Huang WK, Teng LJ, Liu CY. Nation-wide surveillance of antimicrobial resistance among non-fermentative Gram-negative bacteria in intensive care units in Taiwan: SMART programme data 2005. Int J Antimicrob Agents 33:266-271, 2009. 57. Jiang X, Zhang Z, Li M, Zhou D, Ruan F, Lu Y. Detection of extended -spectrum -lactamases in clinical isolates of Pseudomonas aeruginosa. Antimicrob Agents Chemother 50:2990-2995, 2006. 58. Jho YS, Park DH, Lee JH, Lyoo YS. Aerobic bacteria from oral cavities and cloaca of snakesin a petting zoo. J Vet Res 51:243-247, 2011. 59. Kapoor S, Gathwala G. Aztreonam. Indian Pediatr 41:359-365, 2004. 60. Kerr KG, Snelling AM. Pseudomonas aeruginosa: a formidable and ever-present adversary. J Hosp Infect 73:338-344, 2009. 61. Kodala H, Iwata M, Yumoto S, Kashitani F. Evaluation of a new agar medium containing cetrimide, kanamycin and nalidixic acid for isolation and enhancement of pigment production of Pseudomonas aeruginosa in clinical samples. J basic Microbiol 42:407-413, 2003. 62. Kong KF, Jayawardena SR, Del Puerto A, Wiehimann L, Laabs U, Tummler B, Mathee K. Chracterization of poxB, a chromosomal-encoded Pseudomonas aeruginosa oxacillinase gene. Gene 26:82-92, 2005. 63. Lam KK, Crow P, Leung Ng KH. The cross-sectional survey of snake oral bacterial flora from Hong Kong, SAR, China. J Emerg Med 28:107-114, 2010. 64. Lambert PA. Mechanisms of antibiotic resistance in Pseudomonas aeruginosa. J R Soc Med 95:22-26, 2002. 65. Lanotte P, Watt S, Mereghetti L. Genetic features of Pseudomonas aeruginosa isolates from cystic fibrosis patients compared with those of isolates from other origins. J Med Microbiol 53:73-81, 2004. 66. Lauderdale TL, McDonald LC, Shiau YR, Chen PC, Wang HY, Lai JF, Ho M. The status of antimicrobial resistance in Taiwan among Gram-negative pathogens: the Taiwan surveillance of antimicrobial resistance (TSAR) program, 2000. Diag Microbiol Infect Dis 48:211-219, 2004. 67. Lee YJ, Liu HY, Lin YC, Sun KL, Chun CL, Hsueh PR. Fluoroquinolone resistance of Pseudomonas aeruginosa isolates causing nosocomial infection is correlated with levofloxacin but not ciprofloxacin use. Int J Antimicrob Agents 35:261-264, 2010. 68. Livermore DM. Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: our worst nightmare? Clin Infect Dis 34:634-640, 2002. 69. Livermore DM. Interplay of impermeability and chromosomalβ-lactamase activity in imipenem-resistant Pseudomonas aeruginosa. Antimicrob Agents Chemother 36:2046-2048, 1992. 70. Llarrull LI, Testero SA, Fisher JF, Mobashery S. The future of the β-lactams. Curr Opin Microbiol 13:551-557, 2010. 71. Lucia LN, Mamuka K, Justine T, Ananda KN, Anthony DH, Eli NP, Judith AJ, Dave T, Alexander S, Morris JG, Stine OC. Multilocus sequence typing versus pulsed-field gel electrophoresis for characterization of extended-spectrum beta-lactamase-producing Escherichia coli isolates. J Clin Microbiol 43:1776-1781, 2005. 72. Macfarlane ELA, Kwasnicka A, Ochs MM, Hancock REW. PhoP-PhoQ homologues in Pseudomonas aeruginosa regulate expression of the outer-membrane protein OprH and polymyxin B resistance. J Mol Biol 34:305-316, 1999. 73. Maiden MC, Bygraves JA, Feil E, Morelli G, Russell JE, Urwin R, Zhang Q, Zhou J, Zurth K, Caugant DA, Feavers IM, Achtman M, Spratt BG. Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms. Proc Natl Acad Sci 95:3140-3145, 1998. 74. Masuda N, Gotoh N, Ishii C, Sakagawa E, Ohya S, Nishino T. Interplay between chromosomal β-lactamase and the MexAB-OprM efflux system in intrinsic resistance to β-lactams in Pseudomonas aeruginosa. Antimicrob Agents Chemother 43:400-402, 1999. 75. McDonald LC, Lauderdale TL, Shiau YR, Chen PC, Lai JF, Wang HY, Ho M. The status of antimicrobial resistance in Taiwan among Gram-positive pathogens: the Taiwan surveillance of antimicrobial resistance (TSAR) program, 2000. Int J Antimicrob Agents 23:362-370, 2004. 76. McMurry LM, Oethinger M, Levy SB. Overexpression of marA, soxS or acrAB produces resistance to triclosan in Escherichia coli. FEMS Microbiol Lett 166:305-309, 1998. 77. McPhee JB, Bains M, Winsor G, Lewenza S, Kwasnicka A, Brazas MD, Brinkman FSL, Hancock REW. Contribution of the PhoP-PhoQ and PmrA-PmrB two-component regulatory systems to Mg2+-induced gene regulation in Pseudomonas aeruginosa. J Bacteriol 188:3995-4006, 2006. 78. Montes I, Torresano M. Beekeeper''s arthritis caused by Pseudomonas aeruginosa. Clin Infect Dis 34:1662, 2002. 79. Meyer E, Schwab F, Gastmeier P, Rueden H, Daschner FD. Surveillance of antimicrobial use and antimicrobial resistance in German Intensive Care Units (SARI): a summary of the data from 2001 through 2004. Infection. 34:303-309, 2006. 80. Mekić S, Matanović K, Šeol B. Antimicrobial susceptibility of Pseudomonas aeruginosa isolates from dogs with otitis external. Vet Rec 169:125, 2011. 81. Nakae T, Nakajima A, Ono T. Resistance to beta-lactam antibiotics in Pseudomonas aeruginosa due to interplay between the MexAB-O-prM efflux pump and beta-lactamase. Antimicrob Agents Chemother 43:1301-1303, 1999. 82. National Nosocomial Infections Surveillance System. National nosocomial infections surveillance (NNIS) system report, data summary from January 1992 through June 2004. Am J Infect Control 32:470-485, 2004. 83. Nasim A, Baqi S, Akhtar SF. Pseudomonas aeruginosa endocarditis in renal transplant recipients. Transpl Infect Dis 14:180-183, 2011. 84. Ohnishi M, Sawada T, Hirose K, Sato R, Hayashimoto M, Hata E, Yonezawa C, Kato H. Antimicrobial susceptibilities and bacteriological characteristics of bovine Pseudomonas aeruginosa and Serratia marcescens isolates from mastitis. Vet Microbiol 154:202-207, 2011. 85. Owusu-Anim D, Kwon DH. Differential role of two-component regulatory systems (PhoPQ and PmrAB) in polymyxin B susceptibility of Pseudomonas aeruginosa. Advan Microbiol 2:31-36, 2012. 86. Pitout JDD, Chow BL, Gregson DB, Laupland KB, Elsayed S, Church DL. Molecular epidemiology of Metallo-lactamase-producing Pseudomonas aeruginosa in the Calgary Health Region: emergence of VIM-2-producing isolates. J clin mirobiol 45:294-298, 2007.⭺95; 87. Poole K. Aminoglycoside resistance in Pseudomonas aeruginosa. Antimicrob Agent Chemother. 49:479-487, 2005. 88. Poole K, Gotoh N, Tsujimoto H, Zhao Q, Wada A, Yamasaki T, Neshat S, Yamagishi J, Li XZ, Nishino T. Overexpression of the MexC-MexD-OprJ efflux operon in nfxB-type multidrug resistant strains. Mol Microbiol 21:713-724, 1996. 89. Poole K, Krebes K, McNally C, Neshat S. Multiple antibiotic resistance in Pseudomonas aeruginosa: evidence for involvement of an efflux operon. J Bacteriol 175:7363-7372, 1993. 90. Poole K, Srikumar R. Multidrug Efflux in Pseudomonas aeruginosa: components, mechanisms and clinical significance. Curr Top Med Chem 2:59-71, 2001. 91. Qiu D, Eisinger VM, Rowen DW, Yu HD. Regulated proteolysis controls mucoid conversion in Pseudomonas aeruginosa. Proc Natl Acad Sci 104:8107-8112, 2007. 92. Ramalho R, Cunha J, Teixeira P, Gibbs PA. Modified Pseudomonas agar: new differential medium for the detection enumeration of Pseudomonas aeruginosa in mineral water. J Microbiol Methods 49:69-74, 2002. 93. Reinsch N, Plicht B, Lind A, Janosi RA, Buck T, Kamler M, Jakob H, Naber CK, Erbel R. Recurrent infective endocarditis with uncommon Gram-negative Pasteurella multocida and Pseudomonas aeruginosa: a case report. J Heart Valve Dis 17:710-713, 2008. 94. Rice LB. Mechanisms of resistance and clinical relevance of resistance to β-lactams, glycopeptides and fluoroquinolones. Mayo Clin Proc 87:198-208, 2012. 95. Ross RA, Marzec G. The bacterial diseases of reptiles. Institute for Herpetological Research, Stanford, CA, 1984. 96. Roy-Burman A, Savel RH, Racine S, Swanson BL, Revadigar NS, Fujimoto J, Sawa T, Frank DW, Wiener-Kronish JP. Type III protein secretion is associated with death in lower respiratory and systemic Pseudomonas aeruginosa infections. J Infect Dis 183:1767-74, 2001. 97. Shek KC, Taul KL, Lam KK. Oral bacterial flora of the Chinese Cobra (Naja atra) and bamboo pit viper (Trimeresurus albolabris) in Hong Kong, SAR, China. J Hong Kong Med 15:183-190, 2009. 98. Singh PK, Schaefer AL, Parsek MR, Moninger TO, Welsh MJ, Greenberg EP. Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms. Nature 407:762-764, 2000. 99. Slavtchev RS, Chadli A. Infections and deaths of horned vipers, Cerastes cerastes and lebetin vipers, Vipera lebetina caused by Pseudomonas aeruginosa. Arch Inst Pasteur Tunis 61:415-25, 1984. 100. Soveri T. Observations of bacterial diseases of captive snakes in Finland. Nord Vet Med 36:38-42, 1984. 101. Tenover FC, Arbeit RD, Goering RV, Mickelsen PA, Murray BE, Persing DH, and Swaminathan B. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol 33:2233-2239, 1995. 102. Theakston RD, Phillips RE, Looareesuwan S. Bacteriological studies of the venom and mouth cavities of wild Malayan pit vipers (Calloselasma rhodostoma) in southern Thailand. Trans R Soc Trop Med Hyg 84:875-879, 1990. 103. Thompson RL. Cephalosprin, carbapenem, and monobactam antibiotics. Mayo Clin Proc 62:821-834, 1987. 104. Uno T, Fukuda M, Ohashi Y, Shimomura Y, Ishibashi Y, Inaba M, Inoue Y, Ueda K, Eguchi H, Shiraishi A, Sotozono C, Tagawa Y, Chikama T. Survey of severe contact lens-associated microbial keratitis in Japan. Nihon Ganka Gakkai Zasshi. 115:107-115, 2011. 105. Toovey S, Annandale Z, Jamieson A, Schoeman J. Zebra Bite to a South African Tourist. J Travel Med 11:122-124, 2004. 106. Tsang AY, Denner JC, Brennen PJ, McClatchey JK. Clinical and epidemiological importance of typing Mycobacterium avium complex isolates. J Clin Microbiol 30:479-484, 1992. 107. Tseng SP, Tsai JC, Teng LJ, Hsueh PR. Dissemination of transposon Tn6001 in carbapenem-non-susceptible and extensively drug-resistant Pseudomonas aeruginosa in Taiwan. J Antimicrob Chemother 64:1170-1174, 2009. 108. Vincent JL, Barros DS, Cianferoni S. Diagnosis, management and prevention of ventilator-associated pneumonia. Drugs 70:1927-1944, 2010. 109. Walther SM, Erlandsson M, Burman LG, Cars O, Gill H, Hoff- man M, Isaksson B, Kahlmeter G, Lindgren S, Nilsson L, Olsson-Liljequist B, Hanberger H. Antibiotic prescription practices, consumption and bacterial resistance in a cross section of Swedish intensive care units. Acta Anaesthesiol Scand 46: 1075-1081, 2002. 110. Webber MA, Piddock LJV. The importance of efflux pumps in bacterial antibiotic resistance. J Antimicrob Chemother 51:9-11, 2003. 111. Wei HH, Wu KG, Sy LB, Chen CJ, Tang RB. Infectious endocarditis in pediatric patients: analysis of 19 cases presenting at a medical center. J Microbiol Immunol Infect 43:430-437, 2010. 112. Wellehan JFX, Johnson AJ, Latimer KS, Whiteside DP, Crawshaw GJ, Detrisac CJ, Terrell SP, Heard DJ, Childress A, Jacobson ER. Varanid herpesvirus-1: a novel herpesvirus associated with proliferative stomatitis in green tree monitors (Varanus prasinus). Vet Mirco 105:83-92, 2004a. 113. Wellehan JFX, Nichols DK, Li LL, Kapur V. Three novel herpesviruses associated with stomatitis in Sudan plated lizards (Gerrhosaurus major) and a black-lined plated lizard (Gerrhosaurus nigrolineatus). J Zoo Wildl Med 35:50-55, 2004b. 114. Ziha-Zarifi I, Llanes C, Hler TK, Pechere JC , Plesiat P. In vivo emergence of multidrug-resistant mutants of Pseudomonas aeruginosa overexpressing the active efflux system MexA-MexB-OprM. Antimicrob Agents Chemother 43:287-291, 1999.
摘要: 爬蟲類的飼養風氣近年來日益興盛,由於人類與爬蟲類寵物的接觸日益頻繁,經由飼養上的互動、飼養設備的污染或咬傷都可能造成菌株及各種抗藥性基因的傳播。爬蟲類口腔中常在的綠膿桿菌為爬蟲類及人類的伺機性病原,因此,瞭解爬蟲類所帶有之綠膿桿菌及其微生物特性有其必要性。本調查的目的在於:一、瞭解台灣中部寵物、門診及野外爬蟲類的口腔綠膿桿菌檢出率;二、試驗各菌株對於meropenem、aztreonam、gentamicin、amikacin、cefotaxime、colistin及pipercillin--tazobactam藥物敏感性;三、利用脈衝式電泳分析各菌株間基因型相關性。本次調查結果,於126隻爬蟲類來源(82隻蛇及44隻蜥蜴)的口腔檢體中,共檢出綠膿桿菌53株總檢出率為42.0%。另收入歷年爬蟲類剖檢病例之綠膿桿菌4株,及長期下痢之陸龜糞便中的綠膿桿菌1株。此外,更針對五組門診病例加以追蹤並重複採樣,以暸解在投予抗生素後,綠膿桿菌之藥物敏感性在表現型及基因型上的變化。藥物敏感性的試驗結果,除了cefotaxime及gentamicin的抗藥性為33.3%及18.5%外,其餘藥物皆具高敏感性。脈衝式電泳結果,58株綠膿桿菌可分出53種不同的圖譜,分析其分型結果整體基因相似度不高且分型混亂,且結果顯示相同飼養環境的菌株間無基因相關性,且同種動物來源的菌株間亦無親緣關係。由三組口腔重複採樣病例的結果可推論,爬蟲類抗生素的使用,可能造成綠膿桿菌抗生素篩選壓力,使敏感性菌株經藥物使用後轉變為非敏感性;由兩組不同部位重複採樣病例可推論,口腔內綠膿桿菌可能為爬蟲類致病性病原,且有兩種以上的綠膿桿菌可在同ㄧ動物體上同時存在。
It is becoming more and more popular these days to own reptiles as pets. However, reptiles are capable of carrying pathogens that are dangerous to humans, such as Pseudomonas aeruginosa, which can be transmitted directly or indirectly to humans through contact with an object contaminated by reptiles, handling of reptiles or through bite wounds. Therefore, knowledge of the bacterial flora of snakes and lizards constitutes important information for humans. The purpose of this survey is to determine: 1. the prevalence of P. aeruginosa in captive and wild reptiles. 2. the sensitivity of P. aeruginosa to meropenem, aztreonam, gentamicin, amikacin, cefotaxime, colistin and pipercillin-tazobactam. 3. the relatedness of the P. aeruginosa in the survey by using pulsed-field gel electrophoresis. Fifty-three out of 126 (42.0%) oral cavities samples collected from 82 snakes and 44 lizards yielded P. aeruginosa isolates. Also, 4 isolates obtained from separate necropsies of lizards and another isolate from a case of long-term diarrhea in a tortoise have been included in the survey. Furthermore, repeated oral swabs from 5 groups of reptiles were observed in order to understand how the change between phenotype and genotype of P. aeruginosa are related to antibiotic sensitivity. The results of antibiotic sensitivity tests showed that there was a low resistance to antibiotics, except in the cases of cefotaxime (33.3%) and gentamicin (18.5%). The results of PFGE revealed that the diversity of P. aeruginosa isolated from reptiles, makes it hard to classify isolates into clusters, and the similarity of the strains has no relation to living environments and animal species. Analyzing the repeated sampling groups revealed that the resistant P. aeruginosa variants might be selected in the oral cavities of reptiles by antimicrobial therapy itself. Furthermore, P. aeruginosa in the oral cavities of reptiles might be opportunistic pathogens, and any two strains of P. aeruginosa might be found in one animal simultaneously.
URI: http://hdl.handle.net/11455/12830
其他識別: U0005-0706201210031500
文章連結: http://www.airitilibrary.com/Publication/alDetailedMesh1?DocID=U0005-0706201210031500
顯示於類別:獸醫學系所

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