Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/12876
標題: 冠狀病毒Poly(A) Tail長度的調節並不具有宿主細胞的專一性
Regulation of Coronaviral Poly(A) Tail Length During Infection Is Not Host Cell-Specific
作者: 蘇奕達
Su, Yi-Da
關鍵字: coronaviral poly(A) tail
冠狀病毒
出版社: 獸醫學系暨研究所
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摘要: 家禽傳染性支氣管炎(Avian infectious bronchitis;IB)是由家禽傳染性支氣管炎病毒(Avian infectious bronchitis virus;IBV)感染雞隻造成呼吸道、泌尿道與生殖道疾病,常導致蛋雞產蛋率下降,肉雞換肉率下降與高死亡率,造成養雞業界嚴重經濟損失;牛傳染性下痢(Bovine infectious diarrhea;BID)是由牛冠狀病毒(Bovine coronavirus;BCoV)感染牛隻造成消化道疾病,常導致乳牛嚴重下痢與產乳量降低,亦造成養牛業界嚴重的經濟損失。冠狀病毒是單股正鏈的RNA病毒,其基因體長約30 kb,而且它的基因體結構跟真核細胞的mRNA相似,有5端非轉譯區、轉譯區、3端非轉譯區以及連接3端非轉譯區的poly(A) tail,先前研究已證實牛冠狀病毒感染HRT-18細胞株其poly(A) tail會隨時間改變而改變,為了探討冠狀病毒poly(A) tail長度的調節在雞與牛冠狀病毒中是否為共同的特徵,以及觀察在不同的宿主細胞是否也有poly(A) tail被調控的狀況,我們利用牛冠狀病毒(BCoV)感染另一種株化細胞BHK-21,以確定牛冠狀病毒(BCoV)的poly(A) tail是否也會隨著時間改變而改變。另外,我們也藉由雞冠狀病毒野外株(IBV-TW1)與疫苗株(IBV-H120)感染雞胚胎腎臟細胞和4日齡SPF小雞,以確定雞冠狀病毒(IBV)野外株或是疫苗株在初代細胞的感染過程中,其poly(A) tail是否也會被調控。結果顯示牛冠狀病毒的poly(A) tail長度在不同的細胞株也會被調節。此外,雞冠狀病毒的野外株以及疫苗株在初代細胞感染過程中,其poly(A) tail的長度在不同的時間也有不同的變化,顯示冠狀病毒的poly(A) tail長度的調控在感染的過程中是冠狀病毒共同的生物特徵,而且沒有宿主細胞的特異性。此外由結果可知,野外株(IBV-TW1)的poly(A) tail長度在感染細胞的過程當中比疫苗株(IBV-H120)的poly(A) tail長,因此推測冠狀病毒的poly(A) tail可能可以做為區別野外株(IBV-TW1)與疫苗株(IBV-H120)的標準之一。
The coronavirus genome is a single-stranded, (+)-sense RNA molecule of ~30 kilobases in length. As with a majority of eukaryotic messenger RNAs, the coronavirus genome contains a 5' cap, 5' and 3' untranslated regions of ~200 and ~300 nucleotides, respectively, and a poly(A) tail of >100 nt. We have found that the length of the poly(A) tail in the bovine coronavirus (BCoV), a group β coronavirus, is regulated throughout infection in human rectal tumor (HRT) cells and baby hamster kidney cell line BHK-21. To determine whether regulation of viral poly(A) tail length is a common feature of coronaviruses, and whether it is host-specific, poly(A) tail length of wild-type avian infectious bronchitis virus, strain TW1 (wt IBV-TW1) , a group γ coronavirus, was studied in the primary chicken embryo kidney(CEK) cells and 4-day-old SPF chickens. By ligating head-to-tail pyrophosphatase-treated viral RNA (+) strands and sequencing across the junction, the poly(A) tail length of wt IBV-TW1 was found to vary in CEK cells and in the trachea of the SPF chickens throughout infection, suggesting that regulation of poly(A) tail length is a common coronavirus phenomenon. Poly(A) tail length variation was similarly found with the IBV vaccine strain H-120 in CEK cells although the overall poly(A) tail length was shorter with this virus in comparison with the poly(A) tail length in IBV-TW1 virus. These results together suggest that the regulation of coronaviral poly(A) tail length during infection is a common feature among coronaviruses and is not host-specific. Furthermore, we speculate that the variation of poly(A) tail length may be an indicator of virulence based on the comparisons between wt IBV-TW1 (virulent) and IBV-H120 (avirulent).
URI: http://hdl.handle.net/11455/12876
其他識別: U0005-1106201215143900
文章連結: http://www.airitilibrary.com/Publication/alDetailedMesh1?DocID=U0005-1106201215143900
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