Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/13028
標題: 睪固酮對於睡眠干擾誘導之疲勞具有保護性的效果
Testosterone plays a protective role in sleep disturbance-induced fatigue
作者: 王偉丞
Wang, Wei-Cheng
關鍵字: sleep disturbance
睡眠干擾
fatigue
testosterone
pyramidal neuron
dendritic spine
疲勞
睪固酮
錐體細胞
樹突棘
出版社: 獸醫學系暨研究所
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摘要: 疲勞是現代人所必須面臨的生活上難題,它會經由過度運動、疾病或睡眠品質不良而產生,並影響中樞神經系統的功能,包括活動力降低,集中力、注意力及記憶變差。疲勞也與性腺功能低下及老化有關,這使人聯想到血清中性荷爾蒙或許可以對抗疲勞。針對這一點,我們最近發現睪固酮可調控大腦皮質錐體細胞的樹突型態。此外,睪固酮已經被證實可以改變海馬回神經元的樹突形態,可被應用於調整認知功能,包括空間與工作記憶。而在本研究中,我們利用睡眠干擾所誘導的疲勞模式來探討睪固酮於疲勞中的可能角色。我們利用睡眠干擾使正常與去勢的雄性大鼠產生中樞疲勞,並檢測其血清中睪固酮的濃度及其疲勞的程度,再利用細胞內染料注射來觀察大腦初級感覺運動皮質第五層及海馬回CA1/CA3之錐體細胞的樹突形態,而結果顯示去勢大鼠有相對於正常大鼠較差的行為表現及較少的樹突棘,若我們補充外源性睪固酮可有效改善去勢大鼠的活動力、水迷宮及負重游泳測試的表現,由此可知,雄性大白鼠體內的睪固酮在疲勞誘導中樞神經細胞樹突型態變化的過程中可能扮演保護的角色。
Fatigue confronts many nowadays. It can be caused by excessive exercise, sickness or sleep disturbance and compromised central nervous functions, including reduced activities and impaired concentration, attention and memory. Fatigue is also associated with hypogonadism and aging, suggesting that serum sex hormone may protect against fatigue. In this regard, we found recently that testosterone modulates the dendrites of cortical neurons. In addition, testosterone has been shown to modulate the dendritic morphologies of hippocampal neurons to underlie its effect on cognitive function, including spatial and working memory. In the present study, we used the sleep disturbance-induced fatigue rat model to find out whether testosterone could influence the induction of fatigue. Both intact and castrated rats were subjected to sleep disturbance induction and level of serum testosterone and the extent of fatigue were evaluated. Intracellular dye injection was used to reveal the dendritic structures of corticospinal and hippocampal CA1/CA3 pyramidal neurons. Results revealed that castrated rats performed poorer behaviorally and showed fewer dendritic spines than intact rats. The exogenous testosterone on castrated rat could significantly improve the performances of activity, Morris water maze and weight-loaded forced swimming test. Thus, we suggest that testosterone plays a preventive role against fatigue induction by reducing the dendritic changes of central neurons.
URI: http://hdl.handle.net/11455/13028
其他識別: U0005-2508201100511900
文章連結: http://www.airitilibrary.com/Publication/alDetailedMesh1?DocID=U0005-2508201100511900
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