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Effect of Exercise and Beta-adrenergic Drugs on Blood Glucose and Hepatic Chromium Levels
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|摘要:||肥胖會造成或惡化許多流行性老化非傳染性疾病，目前己知肥胖症會促使代謝症候群與第二型糖尿病的發生，適當的運動是改善高血糖症狀的方法之一，鉻元素已被證實為胰島素作用的輔因子，可協助細胞內運送葡萄糖代謝，故本實驗為利用飲食誘導肥胖C57BL/6JNarl小鼠，探討規律運動改善代謝異常與體內鉻元素之變化，隨機分組成一次中度運動組、isoproterenol 3 mg/kg組、一次中度運動後propranolol 3 mg/kg組、規律運動組及控制組。結果顯示一次中度運動及isoproterenol會造成升血糖並使肝臟中鉻元素顯著的流失(p<0.05)，然而使用propranolol抑制運動後又會使血糖顯著的平緩並且減少肝臟鉻元素流失，在規律運動後小鼠的禁食血糖、禁食體重及副睪脂肪總重皆顯著的低於控制組，且造成肝臟及肌肉中鉻儲存量增加。綜合上述結果推測beta腎上腺素的活化會造成高血糖及促使肝臟鉻流失且腎臟及尿液中的鉻排泄增多，在於一次中度運動後發生同樣的情形，然而小鼠規律運動後會促使肝臟及肌肉組織的鉻儲存增加，可能是為了供給運動改善細胞能量之利用。|
Obesity causes or exacerbates many health problems. It is now clear that obesity promotes the development of metabolic syndrome and type 2 diabetes. Regular exercise is known to effectively improve hyperglycemia symptom. Chromium has proven to be a cofactor for insulin action, it facilitates the movement of glucose into cells. The objectives of this study are to evaluate whether exercise can alleviate metabolic disorder and alter chromium distribution. Male C57BL/6JNarl mice fed with high fat-diet, were randomly divided into five groups: short term exercise group, isoproterenol 3 mg/kg group, propranolol 3 mg/kg after short term exercise group, long term exercise group and control group. As a result, short term exercise and isoproterenol increased blood glucose, and the contents of Cr in liver were significantly decreased (p<0.05). Propranolol can significantly reduced blood glucose elevation and decrease hepatic Cr loss. The fasting blood glucose, fasting body weight and epididymal fat weight were lower in long term exercise group than that of the control mice. The level of Cr in liver and muscle is increased after long term exercise. In conclusion, the increased blood glucose by isoproterenol stimulation decreased the Cr level in liver, and increased the Cr level in kidney and urine. Similar results were also found after a short term exercise. However, long term exercise reversed the effect by increasing Cr accumulation in liver and muscle. It suggested that the mechanism by which exercise improves insulin response may involve an alteration in Cr distribution.
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