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標題: 犬乳腺腫瘤中異位性軟骨/硬骨生成之組織來源
Histogenesis of Metaplasia in Canine Mammary Mixed Tumors
作者: 陳琪雅
Chen, Chi-Ya
關鍵字: canine mammary mixed tumor
出版社: 獸醫學系暨研究所
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摘要: Abstract Mammary tumors are the most common tumors in female dogs, and are known for their biologic and histomorphologic heterogeneity. In canine mammary mixed tumors, dominant ectopic cartilage and bone formation accompanied by abundant proliferation of myoepithelial cells is observed frequently, which is a unique features of canine mammary tumors because it was occasionally described in human.. To investigate the histogenesis of cartilage and/or bone in canine mammary tumors, we utilized different immunohistochemical (IHC) markers and histochemial methods in 22 benign and 78 malignant mixed tumors in female dogs. IHC markers included p63, CK14, CK8/18 and vimentin. Histochemical methods included alcian blue and mucicarmine staining was conducted to determine the distribution of cartilage and mucin, respectively. Immunohistochemically, p63-positive cells usually found next to the ectopic cartilage or between the glandular cells and cartilage, and in the connective area of the tubular-papillary type where may develop metaplastic areas. In metaplastic area, large amount of the cells showed reactivity for vimentin. This results showed that there is loss of expression of p63 and cytokeratins in areas of myoepithelial proliferation, and enhanced expression of vimentin protein in proliferative areas with chondroid metaplasia. Therefore, we suggested that ectopic cartilage or bone development followed by metaplasia, which may be triggered by myoepithelial cells, and the mucin substance was used as a medium for development of ectopic cartilage.
其他識別: U0005-0207200812245600
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