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標題: 台灣牛、羊及中部地區犬、貓、鼠Q熱流行病學之研究
Seroepidemiological study of Q fever in cattle and goats from Taiwan and dogs, cats, and mouse from central Taiwan
作者: 謝睿純
Hsieh, Jui-Chun
關鍵字: Q fever

出版社: 獸醫學系暨研究所
引用: 丁崇桂。應用聚合酶鏈鎖反應技術檢測南台灣犬隻萊姆病及Q熱,碩士論文。國立屏東科技大學獸醫學系。1-54,2004。 台灣疾管局(行政院衛生署疾病管制局)。防疫檢體採集手冊。第三版。台灣,1-71,2009。(Retrieved in December, 2009, from 台灣疾管局(行政院衛生署疾病管制局)。傳染病病例定義。第三版。台灣。1-125,2010a。(Available online: 台灣疾管局(行政院衛生署疾病管制局)。傳染病統計資料查詢系統:第四類法定傳染病。2010b。(Retrieved in May, 2010 from: 台灣動檢局(行政院農業委員會動植物防疫檢疫局)。動物傳染病防治條例之動物傳染病分類。2008。(Retrieved in December, 2009, from 池有容。以巢式聚合酶鏈鎖反應調查台灣反芻動物Q熱之流行病學,碩士論文。國立中興大學獸醫學系。1-54,2009。 行政院農委會。98年畜牧農情概況。2009。(Available online: 徐爾烈,吳尹文。野鼠之分類鑑定。標準作業手冊系列10:農田野鼠偵察調查。行政院農業委員會動植物防疫檢疫局、國立台灣大學昆蟲系、金門縣動植物防疫所,台灣。18-25,1997。 Aitken ID. Clinical aspects and prevention of Q fever in animals. Eur J Epidemiol 5: 420-424, 1989. Angelakis E, Raoult D. Q fever. Vet Microbiol 140: 297-309, 2010. Arricau-Bouvery N, Rodolakis A. Is Q fever an emerging or re-emerging zoonosis? Vet Res 36: 327-349, 2005. Arricau-Bouvery N, Souriau A, Bodier C, Dufour P, Rousset E, Rodolakis A. Effect of vaccination with phase Ⅰ and phase Ⅱ Coxiella burnetii vaccines in pregnant goats. 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摘要: Q熱(Query fever)是貝氏考克斯菌(Coxiella burnetii)所引起的高傳染性人畜共通傳染病,目前已知C. burnetii可感染多種動物,其中反芻動物為最主要的保菌宿主。受感染的人及動物大多不會有臨床症狀,少數急性感染期的人類會引致發燒、非典型肺炎、肝炎或於慢性感染時併發心內膜炎等;在動物則偶會引起懷孕末期的流產或其他繁殖障礙的問題,感染動物可經分娩胎液、胎盤、流產胎兒、陰道黏液、糞便、尿液或乳汁等途徑排菌。在台灣目前並無具代表性的動物流行病學調查,故本研究利用高敏感度及特異度之血清學試驗,包含酵素連結免疫吸附分析法(enzyme-linked immunosorbent assay, ELISA)及間接免疫螢光染色法(indirect immunofluorescent assay, IFA),調查台灣牛羊等反芻動物以及中部地區之犬、貓、鼠Q熱抗體盛行率,提供台灣對於Q熱防治與防疫上有更完整的流行病學資料參考。結果顯示在牛總抗體盛行率為8.4 % (51/607)、其中乳牛盛行率為9.1 % (50/551)、肉牛為1.8 % (1/56)、牛場盛行率為46.7 % (7/15);山羊總抗體盛行率為28.7 % (460/1603),其中乳羊為30.1 % (428/1420)、肉羊為17.5 % (32/183),乳羊場盛行率為62.5 % (148/237)、肉羊場盛行率為100 % (4/4);地區個體盛行率在牛隻是以北部最高(12.0 %),其次為中區(10.3 %)、南區(7.8 %)及東區(1.8 %);乳羊的場盛行率是以南部最高(67.6 %)、其次為中區(62.3 %)、北區(55.6 %)及東區(28.6 %)。犬隻的Q熱抗體總盛行率為24.5 % (61/249)、其中寵物犬有25.6 % (43/168),流浪犬的抗體盛行率則是22.2 % (18/81),貓之抗體總盛行率有27.2 % (53/195),有30.8 % (37/120)的寵物貓抗體陽性、21.3 % (16/75)的流浪貓為抗體陽性,公母抗體陽性比例為0.9:1。鼠之Q熱抗體盛行率為6.5 % (4/62)。山羊及犬貓在台灣為高風險性動物,山羊的高抗體盛行率,尤其是在台灣南部地區,應給現場獸醫師及畜牧相關從業人員有所警惕,在處理現場不明原因流產病例時應做好自我防護;而台灣中部地區小動物的高抗體表現顯示對於多數犬貓有接觸病原的機會,而感染的犬貓則可能會是人類受到Q熱病原感染的潛在風險。
Q fever, a highly infective zoonosis, is caused by obligate intracellular bacterium Coxiella burnetii which has been isolated from varied animal species. Ruminants are the most important reservoirs for the pathogen. There is usually no clinical symptoms, however, some of suffered from acute illness would be febrile, atypical pneumonia, hepatitis, or endocarditis in chronic infection. Reproductive disorders such as abortion are the main manifestation in infected animals which can shed the organisms by birth fluids, placenta, aborted fetus, vaginal mucus, feces, urine, and milk. The aim of this study was to investigate antibodies of Q fever in cattle, goats, dogs, cats and mouse by enzyme-linked immunosorbent assay (ELISA) and indirect immunofluorescent assay (IFA) as epidemiological data of Q fever in Taiwan. The result of seroprevalence was 8.4 % (51/607) in bovine and 28.7 % (460/1603) in caprine, respectively. The prevalence was presented with 9.1 % (50/551) in dairy cattle and 1.8 % (1/56) in beef cattle, and with 30.1 % (428/1420) in dairy goats and 17.5 % (32/183) in meat goats, respectively. Total herd-level prevalence was 46.7 % (7/15) in cattle and higher in goats with 62.5 % (148/237). Region-level prevalence in cattle was highest in North (12.0 %), then Center (9.0 %), South (7.8 %), and East (1.8 %); however, it was highest in South (67.6 %), then Center (62.3 %), North (55.6 %), and East (28.6 %) in dairy goats in Taiwan, respectively. The prevalence in canine was 24.5 % (61/249). It was 25.6 % (43/168) in domestic dogs and 22.2 % (18/81) in stray dogs. Feline-prevalence was 27.2 % (53/195), including 30.8 % (37/120) and 21.3 % (16/75) in domestic and stray cats, respectively. In mouse, seroprevalence of Q fever was 6.5 % (4/62). According to the seroepidemiology, goats, dogs, and cats are the high-risk animals in Taiwan. It might be the warning information about Q fever for veterinarians, farm workers, and even the pet-owners in Taiwan.
其他識別: U0005-1907201013211000
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