請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/14248
標題: 1.鹵化苄基醚在醣類化學的應用 2.鐵金屬催化甲醯胺衍生物與硫醇之交互耦合反應
1.Application of Halogenated Benzyl Ether in Carbohydrate Chemistry 2.Iron-Catalyzed Cross-Coupling Reaction of Formamides with Thiols
作者: 汪彥璋
Wang, Yen-Jhung
關鍵字: 苄基醚
Benzyl Ether

鐵催化
甲醯胺
硫醇
耦合反應
Carbohydrate
Iron-Catalyzed
Formamides
Thiols
出版社: 化學系所
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摘要: 本論文的第一部分我們將介紹醣類在一鍋化下選擇性去保護,第一步利用鈀金屬作為催化劑,Josiphos為雙牙基配體,將以醣類為主體的鹵化物和烷基硫醇進行碳-硫鍵生成反應,在第二步中再加入有機酸,選擇性切斷苄基保護基團去保護成醇類。 硫代胺基甲酯被廣泛用於醫藥以及農藥。本論文的第二部分我們利用便宜、無毒性且環保的二氯化亞鐵作為催化劑。過氧化叔丁醇作為氧化劑,活化甲醯胺的碳-氫鍵,進而與硫醇進行碳-硫鍵生成反應。
The first part of this thesis, we introduce the halogenated benzyl ether as a new protecting group carbohydrate chemistry. First, the combination of palladium acetate (1.0 mol%) and Josiphos (1.0 mol%) can be used as a powerful catalytic system to form C-S bond between halogenated benzyl ethers with thiols. Interestingly, the resulting thioether-containging benzyl group can be selectively removed and afforded the corresponding alcohols. In the second part of this thesis, we report that iron dichloride can be used as a catalyst for the coupling reaction of thiols with formamides in the presence of TBHP as an oxidant.
URI: http://hdl.handle.net/11455/14248
其他識別: U0005-1208201311583800
文章連結: http://www.airitilibrary.com/Publication/alDetailedMesh1?DocID=U0005-1208201311583800
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