Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/14431
標題: 固相萃取結合液相層析串聯質譜術於染髮劑中禁用成分之分析
SPE-LC-MS/MS for determination of prohibited compounds in haie dye
作者: 林采蓉
Lin, Tsai-Jung
關鍵字: 染髮劑
hair dye
固相萃取法
液相層析串聯質譜
SPE
LC-MS/MS
出版社: 化學系所
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摘要: 染髮劑普遍被使用於改變頭髮顏色,但研究證實染髮劑的成分會經由皮膚吸收進入人體,並導致過敏與致癌的風險產生。台灣、歐盟、日本、中國等各國的衛生單位,皆針對染髮劑中部分有害成分立法禁用及限用規定,因此對於染髮劑禁用成分與限用成分的相關研究更顯其重要性。本研究主要是利用固相萃取法(solid phase extraction,SPE)萃取染髮劑中禁用及限用成分,再以LC/MS/MS進行分離及偵測,作為染髮劑中禁用及限用成分分析方法之開發。選定的染髮劑禁用成分及限用成分為2,4-diaminoanisole、2,4-diaminodiphenylamine、HC Yellow No.12、2,3-naphthalenediol、1-methoxy-2,5-diaminobenzene、與限用成分p-phenylenediamine為主要分析物。 由實驗結果顯示使用pH 3緩衝溶液萃取染髮劑中的分析物,取1 mL注入SPEC MP1以及採用1 mL1%NH3(aq)甲醇水溶液進行沖提,對於萃取染髮劑中成分具有良好的萃取效果。所開發之分析方法對於染髮劑中2,4-diaminodiphenylamine、1-methoxy-2,5-diaminobenzene、2,4-diaminoanisole、HC Yellow No.12與p-phenylenediamine之偵測線性範圍介於10~5000 ng/mL之間,2,3-naphthalenediol之偵測線性範圍介於20~5000 ng/mL之間,偵測極限與定量極限分別介於3~6 ng/mL與11~21 ng/mL之間,線性相關係數皆在0.9922以上。所開方法分析染髮劑中禁用與限用成分之同日精密度與異日精密度分別介於0.8~16.9%與2.2~19.3%之間;回收率則介於80.2~120%之間,相對標準偏差為1.5~13.1%之間。應用於偵測市售染髮劑,可測得含有3% p-phenylenediamine、2.1 μg/g 2,4-diaminoanisole與150 μg/g 1-methoxy-2,5-diaminobenzene。本實驗開發之技術將可作為染髮劑成分檢測方法之參考。
Hair dye is usually used to change color of hair, but it is reported that hair dye products are concern of health due to risks of allergic dermatitis. In this study, the laws and regulations for hair dyes in USA, EU, China, Japan and Taiwan were also systematically studied. In these countries, hair dyes were regulated by authoritative administration and the manufactures have the responsibility for the safety of hair dye products. This study is to research the feasibility of solid phase extraction coupled to liquid chromatography-tandem mass spectrometry (SPE-LC-MS/MS) for determination of prohibited components in hair dye. The target prohibited analytes are 2,4-diaminodiphenylamine, 2,4-diaminoanisole, HC Yellow No.12, 2,3-naphthalenediol and 1-methoxy-2,5-diaminobenzene, the restricted analyte is p-phenylene- diamine. As the results shown, the optimum extraction conditions was using SPEC MP1 as extracting cartridge and 1 mL1%NH3(aq) of H2O/MeOH solution as eluting solvent. The linearity of proposed method ranged from 10 to 5000 ng/mL for all analytes expect 2,3-naphthalene- diol (20-5000 ng/mL). The limit of detection and limit of quantitation were 3 ~ 6 ng/mL and 11~21 ng/mL, repsectively. The intra-day and inter-day precisions were 0.8~16.9% and 2.2~19.3% and the recovery ranged from 80.2 to 120%. Finally, the feasibility of applying the proposed method was examined the commercial hair dyes.
URI: http://hdl.handle.net/11455/14431
其他識別: U0005-2507201217540500
文章連結: http://www.airitilibrary.com/Publication/alDetailedMesh1?DocID=U0005-2507201217540500
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