Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/15375
標題: 毛茛在雞體內對鼠傷寒沙門氏桿菌之影響
Effect of Ranunculus japonicus on Salmonella Typhimurium in Chicken
作者: 莊連鋒
Chuang, Lien-Fong
關鍵字: Ranunculus japonicus
毛茛
Salmonella Typhimurium
鼠傷寒沙門氏桿菌
出版社: 獸醫病理生物學研究所
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摘要: 沙氏桿菌症是由一群沙氏桿菌屬(genus Salmonella)的細菌所引發的疾病,為全球性的病原菌,能夠適應不同種類的宿主,且大部分的沙門氏桿菌被視為潛在造成人類疾病的病原。如何有效防治沙氏桿菌症及抗藥性菌株產生,使用中草藥成為可擇的方法。本論文以5種中藥,包括葛根、黃連、黃柏、白术、蒼述;10種草藥,包括毛茛、葉下紅、馬齒莧、火炭母、大飛揚、小飛揚、長春花、七日暈、七日暈(倒)、七日暈(站)為實驗用藥進行有效成份的萃取,以Salmonella Typhimurium﹐Salmonella Choleraesuis﹐Salmonella Newport﹐Salmonella Enteritidis﹐Salmonella Gallinarum﹐Salmonella Pullorum﹐Escherichia coli及Staphylococcus aureus等為試驗用菌。在in vitro實驗中,首先以Disk diffusion method測定中草藥對細菌之抑菌能力,結果以毛茛對試驗用菌具有良好的抑菌效果,在改變毛茛pH在2-8之間,依然具有抑菌的效果。以Agar plate dilution method測定所得到Minimum inhibitory concentration為100mg/ml。毛茛萃取物與Salmonella Typhimurium混合浸泡後以穿透式電子顯微鏡觀察,在第6小時Salmonella Typhimurium呈現細胞壁破裂及細胞崩解現象。在in vivo實驗中,口服5g/kg毛茛萃取物的雛雞及大白鼠皆無死亡病例,感染試驗模式建立中以1×106CFU/ml Salmonella Typhimurium口服接種小雞,第2至72小時在心、肝、脾、肺、腎、華氏囊、卵黃囊、大腸、小腸及膽囊可分離到細菌,證明Salmonella Typhimurium的感染成立。在藥物投與試驗中,小雞接種1×106CFU/ml Salmonella Typhimurium後再投與不同劑量的毛茛萃取液,每隔一段時間犧牲並自臟器分離細菌,結果以口服500mg/kg毛茛,在第24小時後即無分離到沙門氏桿菌,保肝試驗中口服柴胡疏肝散變方可降低毛茛對肝臟的傷害。根據以上實驗結果顯示,毛茛對Salmonella Typhimurium等試驗用菌具有抑制效果,在雞體內對Salmonella Typhimurium也具有抑制作用。
Salmonellosis is a disease caused by a group of bacteria of the genus Salmonella which are global pathogens. They can adapt to different kinds of host and most of Salmonella spp are regarded as the potential causative pathogens of human diseases. Traditional Chinese medicinal herbs can be used as an alternative way to control Salmonellosis and to prevent the development of drug-resistant strain. In this thesis, 5 Chinese medicines, including Pueraria lobata, Coptis chinensis, Cortex phellodendri, Atractylodes macrocephala and Atractylodes lancea; as well as 10 herbs, including Ranunculus japonicus, Emilia sonchifolia, Portulaca oleracea, Polygonum chinese, Euphorbia hirta, Euphorbia thymifolia, Catharanthus roseus and Breynia officinalis were used to extract the effective ingredient from the medicine specimens. Salmonella Typhimurium, Salmonella Choleraesuis, Salmonella Newport, Salmonella Enteritidis, Salmonella Gallinarum, Salmonella Pullorum, Escherichia coli, Staphylococcus aureus etc. were the bacteria used. In in vitro studies, Disk diffusion method was used to determine the bacterial inhibiting ability of traditional Chinese medicinal herbs. The result showed that Ranunculus japonicus had the best bacterial inhibiting ability against the bacteria specimens, even changing the pH of Ranunculus japonicus between 2 and 8. Minimum inhibitory concentration was determined to be 100mg/ml with Agar Plate Dilution Method. After mixing Ranunculus japonicus extract and Salmonella Typhimurium and observing under transmission electron microscope, Salmonella Typhimurium cell wall was ruptured and cell lysed at 6th hour. In in vivo studies, no death was found in chicken and rats whom were administrated 5g/kg Ranunculus japonicus extract. In the infection model of oral inoculation of 1106CFU/ml Salmonella Typhimurium in chicken, bacteria can be isolated from the heart, liver, spleen, lung, kidney, bursa, yolk sac, large intestine, small intestine and gall bladder between the 2nd and the 72nd hour, which proved Salmonella Typhimurium infection. In medication test, the chicks were first inoculated with 1106CFU/ml Salmonella Typhimurium followed by various doses of Ranunculus japonicus extract. The chicks were killed at regular intervals and bacterial isolations from the offals were performed. The result showed that Salmonella was not found after 24 hours when 500mg/kg Ranunculus japonicus was administrated. In liver protectiont test, oral taking modified Chai-Hu-Shu-Gan-Tong could reduce liver damage caused by Ranunculus japonicus. The above results showed that Ranunculus japonicus had an inhibitory effect on the bacteria used such as Salmonella Typhimurium and it can also inhibit Salmonella Typhimurium in chicken.
URI: http://hdl.handle.net/11455/15375
其他識別: U0005-2806200809324300
文章連結: http://www.airitilibrary.com/Publication/alDetailedMesh1?DocID=U0005-2806200809324300
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