Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/16396
標題: 利用簡單的氯化銅系統進行碳-碳三鍵偶合反應、環合反應及碳-硫偶合反應以完成一鍋合成苯駢[b]&;#22139;吩衍生物之研究
The study in cascade reactions of Csp2-Csp cross-coupling(Sonogashira-type reaction)、cyclization and Csp2-S cross-coupling(Ullmann-type reaction) for one-pot three-step synthesis of benzo[b]thiophene derivatives using a simple copper-chloride system.
作者: 林哲毅
Lin, Zhe-Yi
關鍵字: benzo[b]thiophene
出版社: 化學系所
摘要: 二,三雙取代的苯駢[b]&;#22139;吩經由末端炔類與二-碘硫代苯甲醚透過鈀催化與親電性環合反應,可以得到良好的產率是已經被報導出來的。 我們發展一個新的合成路徑,利用三步一鍋化反應得到苯駢[b]&;#22139;吩的衍生物,在不需要配位基與鈀金屬,只用氯化銅當催化劑與環合試劑,不中止反應下,成功的得到良好的產率。
It has been known that 2,3-disubstituted benzo[b]thiophenes have been prepared in excellent yields via coupling of terminal alkynes with commercially available o-iodothioanisole in the presence of a palladium catalyst and subsequent electrophilic cyclization of the resulting o-(1-alkynyl)thioanisole derivatives. We have developed a new synthetic method that by using copper choride-mediated cascade reactions of Csp2-Csp coupling, intramolecular cyclization, and Csp2-S coupling without using palladium catalyst and any ligand for one-pot three-step syntheses of 2,3-disubstituted benzo[b]thiophenes.
URI: http://hdl.handle.net/11455/16396
Appears in Collections:化學系所

文件中的檔案:

取得全文請前往華藝線上圖書館



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.