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Positive Association of Ankylosing Spondylitis with Homozygous HLA-B27, but Protection with B2705 in Taiwan Chinese
Human lymphocyte antigen
|摘要:||僵直性脊椎炎(Ankylosing spondylitis, AS)是常見的慢性病之一，有超過90%以上的病人為人類白血球抗原 (Human lymphocyte antigen, HLA) HLA-B27抗原陽性。我們利用Polymerase chain reaction-restrictive fragment length polymorphism, PCR-RFLP的方法分析HLA-B27的亞型與僵直性脊椎炎的關係。我們發現在738位年紀超過65歲的正常人中，有42位(5.69%)為HLA-B27抗原陽性；其中6位(14.3%)為B2704的同合子；18位(42.9%)為B2704的異配子；2位(4.8%)同時有B2704及B2705, 1位(2.3%)同時有B2704及B2706；2位(4.8%)為B2705的同合子；11位(26.1%)為B2705的異配子及2位(4.8%)為B2706的異配子。而在62位罹患僵直性脊椎炎的病人中，37位(59.6%)為B2704的同配子；而25位(40.3%)則為B2704的異配子。由此可知，HLA-B27的帶原率在台灣地區約為5.69%左右，而同合子的B2704與僵直性脊椎炎的發病有關，但在本研究中發現B2705可能具有保護作用。|
The study was undertaken to determine the effects of HLA-B27 subtypes on susceptibility to ankylosing spondylitis (AS) in Taiwan Chinese. A polymerase chain reaction-restrictive fragment length polymorphism (PCR-RFLP) method was developed for subtyping of HLA-B27. In this series, there are 62 patients with AS who were tested HLA-B27 positive serologically and 738 normal persons over the age of 65. Among the 738 normal controls, 42 (5.7%) were HLA-B27 positive. There were six (14.3%) homozygous for B2704, 18 (42.9%) heterozygous for B2704, 2 (4.8%) double heterozygous for B2704 and B2705, one (2.3%) double heterozygous for B2704 and B2706, 2 (4.8%) homozygous for B2705, 11 (26.1%) heterozygous for B2705, and 2 (4.8%) heterozygous for B2706. In our patients with AS, 37 (59.7%) were homozygous for B2704 and 25 (40.3%) were heterozygous for B2704. The HLA-B27 carrier rate in Taiwan healthy old persons is estimated as 5.69%. Susceptibility to AS is determined by homozygosity for B2704. However, B2705 may be an indicator of protection against AS in Taiwan Chinese.
|Appears in Collections:||生命科學系所|
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