Please use this identifier to cite or link to this item:
Formation of droplet and mixing through flow-focusing on stationary and rotating microfluidics
|引用:||Anna SL, Bontoux N, Stone HA, “Formation of dispersions using “flow focusing” in microchannels. ” Applied Physics Letters, Vol. 82, 2003, pp. 364-366. Beer NR, Hindson B, Wheeler E, Hall S, Rose K, Kennedy I, Colston B, “On-chip, real-time, single-copy polymerase chain reaction in picoliter droplets, ” Analytical Chemistry, Vol. 79, 2007, pp. 8471-8475. Bendib S, Francais O,“Analytical study of microchannel and passive microvalve application to micropump simulator, ” In: Proceedings of the SPIE, 1999, pp. 200-208. Bringer MR, Gerdts CJ, Song H, Tice JD, Ismagilov RF, “Microfludic systems for chemical kinetics that rely on chaotic mixing in droplet,” Philosophical Transactions of the Royal Society of London.Series A:Mathematical, Physical and Engineering Sciences, Vol. 362, 2004, pp. 1087-1104. Chatterjee D, Hetayothin B, Wheeler AR, King DJ, Garrell RL ,“Droplet-based microfluidics with nonaqueous solvents and solutions, ” Lab Chip,Vol.6, 2006, 6, 199-206. Chen DL, Ismagilov RF, “Microfluidic cartridges preloaded with nanoliter plugs of reagents: an alternative to 96-well plates for screening , ” Current Opinion in Chemical Biology , Vol.10, 2006, pp. 226-231. Cheow LF, Yobas L, Kwong DL, “Digital microfluidics: Droplet based logicgates, ” Applied Physics Letters, Vol. 90, 2007, pp.054107. Dean WR, Note on the motion of fluid in a curved pipe. Philosophical Magazine, Vol 7, 1928, pp. 208-223. Dittrich PS, Manz A, “Lab-on-a-chip: microfluidics in drug discovery ”, Nature Reviews Drug Discovery, Vol. 5, 2006, pp. 210-218. Fuerstman MJ, Garstecki P, Whitesides G.M, “Coding/decoding and reversibility of droplet trains in microfluidic networks, ” Science, Vol. 315, 2007, pp. 828-832. Ganguli D, Ganguli M, “Inorganic particle synthesis via macro- and microemulsions, ” Kluwer Academic/Plenum Publishers, New York, 2003. Gustafsson M, Hirschberg D, Palmberg C, Jörnvall H, Bergman T, “Integrated sample preparation and MALDI mass spectrometry on a microfluidic compact disk,” Analytical Chemistry, Vol. 76, No.2, 2004, pp. 345-350. Handique K , Burns MA., “Mathematical modeling of drop mixing in a slit-type Microchannel,” J. Micromech.Microeng , Vol. 11, 2001, pp. 548-554. Hsieh ATH, Patrick JHP, Abraham PL, “Rapid label-free DNA analysis in picoliter microfluidic droplets using FRET probes, ” Microfluidics and Nanofluidics, Vol. 6(3), 2009, pp. 391-401. Huang SH, Tan WH, Tseng FG, Takeuchi S, “A monolithically three-dimensional flow-focusing device for formation of single/double emulsions in closed/open microfluidic systems, ”Journal of Micromechanics and Microengineering, Vol. 16, 2006, pp. 2336-2344. Liau A, Karnik R, Majumdar A, Cate JHD, “Mixing crowded biological solutions in milliseconds,” Anaytical Chemistry, Vol. 77, 2005, pp. 7618-7625. Manzs A, Graber N, Widmer HM, “Miniaturized Total Analysis Systems: A Novel Concept for Chemical Sensing”, Sensors and Actuators, Vol. B1, 1990, pp.244-248. Nguyen NT, Beyzavi A, Ng KM, Huang X, “Kinematics and deformation of ferrofluid droplets under magnetic actuation,” Microfluidics and Nanofluidics, Vol. 3, 2007, pp. 571-579. Nisisako T, Torii T, Higuchi T, “Droplet formation in a microchannel network, ” Lab Chip, Vol. 2, 2002, pp. 24-26. Paik P, Pamula VK, Pollack MG, Fair RB,“Electrowetting-based droplet mixers for microfluidic systems, ” Lab Chip, Vol. 3, 2003, pp. 28-33. Paik P, Pamula VK, Fair RB, “Rapid droplet mixers for digital microfluidic systems, ” Lab Chip, Vol. 3, 2003, pp. 253-259. Pollack MG, Shenderov AD, Fair RB, “Electrowetting-based actuation of droplets for integrated microfluidics, ” Lab Chip,Vol. 2, 2002, pp. 96-101. Priest C, Herminghaus S, Seemann R, “Generation of monodisperse gel emulsions in a microfluidic device, ” Applied Physics Letters, Vol. 88, 2006, pp. 024106. Reyes DR, Iossifidis D, Auroux PA, Manz A, “Micro total analysis systems 1.Introduction, theory and technology, ” Analytical Chemistry,Vol. 74, 2002, pp. 2623-2636. Sanders G. H. W. and Manz A., “Chip-based microsystem for genomic and proteomic analysis,” Trends in Analytical Chemistry, Vol. 19, 2000, pp. 364-378. Sarrazin F, Prat L, Di Miceli N, Cristobal G, Link DR, Weitz DA, “Mixing characterization inside microdroplets engineered on a microcoalescer, ” Chemical Engineering Science, Vol. 62, 2007, pp. 1042-1048. Shakhashiri BZ, Chemical Demonstrations: A Handbook for Teachers of Chemistry, University of Wisconsin Press: Madison, WI, Vol. 1, 1983, pp. 341-343. Shoji S, Esashi M, “ Microflow device and systems ”, Journal of Micromechanics and Microengineering , Vol.4, 1994, pp.157-171 . Song H, Tice JD, Ismagilov RF, “A microfluidic system for controlling reaction networks in time, ”Angewandte Chemie International Edition, Vol. 42, 2003, pp. 768-772. Song H, Li HW, Munson MS, Ha TGV, Ismagilov RF, “On-chip titration of an anticoagulant argatroban and determination of the clotting time within whole blood or plasma using a plug-based microfluidic system, ” Analytical Chemistry, Vol. 78, 2006, pp. 4839-4849. Srinivasan V, Pamula VK, Fair RB, “An integrated digital microfluidic lab-on-a-chip for clinical diagnostics on human physiological fluids , ” Lab Chip , Vol. 4 , 2004, pp. 310-315. Tan YC, Cristini V, Lee AP, ”Monodispersed microfluidic droplet generation by shear focusing microfluidic device, ” Sensors and Actuators B-chemical, Vol. 114, 2006, pp. 350-356. Teh SY, Lin R, Hung LH., Lee AP, “Droplet microfluidics, ” Lab Chip, Vol 8, 2008, pp. 198. Thorsen T, Roberts RW, Arnold FH, Quake SR, “Dynamic pattern formation in a vesicle-generating microfluidic device, ” Physical Review Letters, Vol 86, 2001, pp. 4163-4166. Tice JD, Song H, Lyon AD, Ismagilov RF, “Formation of droplets and mixing in multiphase microfluidics at low values of the Reynolds and the capillary numbers, ” Langmuir, Vol. 19, 2003, pp. 9127-9133. Wheeler AR, Moon H, Kim CJ, Loo JA, Garrell RL, “Electrowetting-based microfluidics for analysis of peptides and proteins by matrix-assisted laser desorption/ionization mass spectrometry, ” Analytical Chemistry, Vol. 76, 2004, pp. 4833-4838. Woodward A, Cosgrove T, Espidel J, Jenkins P, Shaw N, “Monodisperse emulsions from a microfluidic device, characterised by diffusion NMR, ” Soft Matter, Vol 3, 2007, pp. 627-633. Wheeler AR, Moon H, Bird CA, Loo RRO, Kim CJ, Loo JA, Garrell RL, “Digital microfluidics with in-line sample purification for proteomics analyses with maldi-ms, ” Analytical Chemistry, Vol. 77, 2005, pp. 534-540. Xu JH, Li SW, Tan J, Wang YJ, Luo GS, “Preparation of highly monodisperse droplets in a T-junction microfluidic device,” AIChE Journal, Vol. 52, 2006, pp. 3005-3010. Yobas L, Martens S, Onga WL, Ranganathan N, “High-performance flow- focusing geometry for generation of monodispersed droplets, ” Lab Chip, Vol. 6, 2006, pp. 1073-1079. Zheng B, Tice JD., Ismagilov RF, “Formation of arrayed droplets by soft lithography and two-phase fluid flow, and application in protein crystallization,” Advanced Materials, Vol. 16, No. 15, 2004, pp. 1365-1368. Zhou CF, Yue PT, Feng JJ, “Formation of simple and compound drops in microfluidic devices, ” Physics of Fluids, Vol. 18, 2006, pp. 092105.|
|摘要:||本研究分別以壓力及離心力驅動微流道流體，利用流體聚焦(flow-focusing)方式使消散相流體頸縮，生成由兩種液體混合的微液滴，觀察其混合效率。為了迅速增強液滴內的混合效率，流體聚焦流道下游增加製作U型流道之混合區。我們使用黃光微影製程製作母模，並利用PDMS轉印微流道結構。實驗流體以油為連續相流，水為消散相流，產生油包水(water-in-oil)的微液滴，經由可視化設備觀察液滴生成與混合現象。在壓力驅動實驗中，連續相與消散相流道寬度為100 μm，固定消散相流率為0.01 ml/hr，調整連續相流率於0.02 - 0.06 ml/hr的範圍，可產生成直徑114~135 μm的液滴。在流體聚焦處剛生成的液滴，由於頸縮作用可提供60 %的預混合效率，再搭配下游U型混合區，混合效率可迅速提升至95 %。在離心力驅動實驗中，連續相與消散相流道寬度分別為300 與200 μm，可生成微液滴的範圍為400-700 rpm。在轉速400、500及700 rpm下，可生成液滴直徑分別為402、452與900 μm，搭配U型混合區，混合效率可達80%以上。|
Experiments were carried out to investigate fluid mixing within droplets generated using the flow-focusing method in microchannels. Polydimethylsiloxane (PDMS) was employed to fabricate the microchannels using the photolithography technique. The microchannels were composed of a Y-junction to bring two types of liquids into contact, a cross-junction to from droplets and a U-shaped channel to further enhance the droplet mixing. Oil as a continuous-phase flow and water as a dispersed-phase flow were injected into the channels by syringe pumps or by centrifuge on a rotating disk. In the pressure-driven microchanels that had the same width of 100 μm, the continuous-phase flow rate was varied between 0.02-0.06 ml/hr (at a constant dispersed-phase flow rate of 0.01 ml/hr) to produce droplets having diameters ranging between 114 to 135 μm. It is found that the mixing efficiency can reach as much as 60% when the droplet is just formed via flow focusing and the downstream U-shaped channel easily raises it to around 95%. In the centrifuge-driven microfluidcs that consists of a 300-μm-width continuous-phase channel and a 200-μm-width channel dispersed-phase channel, the droplets can be formed only at a certain range of rotational speed, 402-452 μm in diameter at 400-500 rpm and 900 μm in diameter at 700 rpm. It is also found that mixing efficiency can be largely increased to about 85% for the channels with U-shaped structure.
|Appears in Collections:||機械工程學系所|
Show full item record
TAIR Related Article
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.