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標題: 麩胺酸鈉對肥育期白羅曼鵝生長性能、脂肪及肌肉生成相關基因表達與屠體性狀之影響
Effects of monosodium glutamate on growth performance, lipogenic and myogenic gene expressions, and carcass characteristics in White Romance geese (Anser anser) during finishing period
作者: 彭炳德
Buangam, Apidech
關鍵字: goose

dietary monosodium glutamate
body weight gain
feed efficiency
出版社: 動物科學系所
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摘要: 因台灣鵝隻於夏季之採食量大幅減少,本篇研究目標為探討麩胺酸鈉 (monosodium glutamate) 對鵝隻生長性能及血漿性狀之影響。當鵝隻於九週齡時,每二日皮下注射麩胺酸鈉 (0, 0.1 and 0.5 mg/g of BW) 或於飼糧中添加不同濃度之麩胺酸鈉 (0%, 2% and 4%)。結果顯示,飼糧中添加麩胺酸鈉 (特別是 2%) 及皮下注射低劑量的麩胺酸鈉 (0.1 mg/g of BW) 顯著提高鵝隻飼料踩食量、體增重及飼料效率 (P<0.05),但對肝臟及腹脂之重量及佔體重之比率並無顯著影響。飼糧添加麩胺酸鈉所誘發的採食量上升,並不影響下視丘之 NPY (neuropeptide Y) 及 MC4-R (melanocortin 4 receptor) 之基因表達,然皮下注射低劑量麩胺酸鈉可減少下視丘 MC4-R 之基因表達。在血漿性狀方面,飼糧中添加麩胺酸鈉並不影響血漿中葡萄糖、NEFA、triiodthyronine (T3)及thyroxine (T4) 之含量,且對 GOT (glutamic oxaloacetic transaminase) 及 GPT (glutamic pyruvic transaminase) 之活性亦無影響;然飼糧中添加 4% 麩胺酸鈉顯著提高血漿中 triglyceride (TG) 及 uric acid 之濃度 (P<0.05)。於本次試驗中,carboxyl-CoA carboxylase (ACC)、fatty acid synthase (FAS)、 Peroxisome proliferator activated receptor-γ (PPAR-γ)、sterol response element binding protein-1 (SREBP-1)、lipoprotein lipase (LPL)、insulin like growth factor-1 (IGF-1)、growth hormone receptor (GHR)、myostatin (Myst) 及 leucyl-tRNA synthetase (leu-tRNA synt) 用於檢測樣品中脂肪及肌肉生成相關基因之表達;由結果可看出,飼糧中添加麩胺酸鈉所促進之生長性能改善,可能與 IGF-1、leu-tRNA synt 及 LPL 於腿肌之提高及 Myst 於胸肌之抑制有關;飼糧中添加麩胺酸鈉不影響所檢測與脂肪相關基因於腿肌之表達,但胸肌之 FAS 及 PPAR-γ 受到抑制,其與胸肌 TG 含量之下降 (P<0.05) 一致。飼糧中添加麩胺酸鈉亦顯著提高肝臟 SREBP-1、 IGF-1、ACC 及脂肪組織 FAS 之基因表達。脂肪與肌肉生成相關基因之改變與肌纖維直徑及其 physical myofibril fragmentation index (MFI) 一致。綜合上述結果,飼糧中添加 2% 麩胺酸鈉有助於提昇鵝隻之生長性能。
Objectives of this study were aimed to assess the effect of MSG to stimulate growth performance and plasma parameters of geese, since geese tend to be anorexic during summer season in Taiwan. Geese at age of 9 weeks old were subjected to subcutaneous (SC) administration of MSG (0, 0.1 and 0.5 mg/g of BW) every 2 days, or receiving diet supplemented with different levels of MSG (0%, 2% and 4% of feed). Results suggested dietary supplementation of MSG, particularly at 2% level, and SC administration of MSG at a low dose (0.1 mg/g of BW) significantly promoted daily feed intake, BW gain and feed efficiency (P<0.05) without a significant effect on absolute and fractional liver and abdominal fat content. This increased feed intake by dietary MSG was not associated with NPY (neuropeptide Y) and MC4-R (melanocortin 4 receptor) regulation in the hypoythalamus, but was mediated by downregulation of hypothalamic MC4-R expression in geese with SC administration of MSG at a low dose. In plasma parameters, dietary MSG inclusion exerted no effect on plasma glucose, NEFA, triiodthyronine (T3), thyroxine (T4) levels, and GOT (glutamic oxaloacetic transaminase), and GPT (glutamic pyruvic transaminase) activity, but MSG inclusion at 4% promoted plasma triglyceride (TG) and uric acid concentration (P<0.05). Collected samples were used for lipogenic and myogenic gene expression, comprising acetyl CoA carboxylase (ACC), fatty acid synthase (FAS), Peroxisome proliferator activated receptor-γ (PPAR-γ), sterol response element binding protein-1 (SREBP-1), lipoprotein lipase (LPL), insulin like growth factor-1 (IGF-1), growth hormone receptor (GHR), myostatin (Myst), leucyl-tRNA synthetase (leu-tRNA synt). Results suggested that the improved growth performance by dietary MSG was associated with upregulation of IGF-1, leu-tRNA synt and LPL in leg muscle and suppressed Myst expression in breast muscle (P<0.05). Dietary MSG did not alter the selected lipogenic gene expressions in leg muscle, but downregulated FAS and PPAR-γ in breast muscle with consistent alterations of TG content (P<0.05). Dietary MSG also significantly promoted hepatic SREBP-1, IGF-1 and ACC expression and adipose tissue FAS. The lipogenic and myogenic alterations were concomitantly associated with myofiber diameter and physical myofibril fragmentation index (MFI). Based on the results, we concluded dietary supplementation of MSG at 2% level as the best recommendation use to promote goose growth performance.
其他識別: U0005-1808201018001600
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