Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/28025
標題: 運動後攝取高脂肪餐對於細胞激素之影響
The Influence of High Fat Meal after Exercise on Plasma Cytokines Concentration
作者: 陳念亭
Chen, Nien-Ting
關鍵字: cytokine
細胞激素
inflammation
high fat meal
c-reactive protein
發炎反應
高脂肪餐
C-反應蛋白
出版社: 運動與健康管理研究所
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摘要: 動脈粥狀硬化部份原因是由於長期的全身慢性發炎而導致,近幾年來,動脈粥狀硬化發病的機制,學者已把焦點集中在發炎上。過去研究發現運動似乎可提供保護作用,對抗動脈粥狀硬化及胰島素阻抗,而細胞激素、發炎的指標目前也作為預測心血管疾病的重要因子。適度的運動可能會促使抗發炎的細胞激素增加,使得前發炎之細胞激素減少。本研究的目的是探討在運動介入之下攝取高脂肪餐後對於體內細胞激素的影響。以有規律運動的健康男性8名為受試者,每次間隔一週,,採用交叉隨機實驗設計,受試者完成2次實驗,分別為休息(RE)組、運動(EX)組,受測者攝取葡萄糖30分鐘後運動組以強度60% VO2max於跑步機上跑步60分鐘,控制組則安靜休息60分鐘,並於運動後或安靜休息後給予口服脂肪耐受性測試餐(1.2 g/kg 脂肪,1.1 g/kg碳水化合物,0.33 g/kg蛋白質),收集餐後血液樣本,分析血漿中的發炎指標CRP及細胞激素TNF-α、IL-1α、IL-6、IL-8、IL-10蛋白及mRNA。攝取高脂肪餐後,運動的介入CRP有顯著的降低,IL-6蛋白則是增加,而TNF-α、IL-1α、IL-8、IL-10蛋白與mRNA以及IL-6 mRNA並無顯著增加。本研究運動介入對於脂肪耐受性並對於細胞激素兩組之間無顯著影響。
Long-term systemic chronic inflammation is one of the main reasons leading to atherosclerosis. In the past few years, researcher has been focus on the role of inflammation in the pathogenesis of atherosclerosis. Previous studies have shown that exercise might provide the protective effect to against atherosclerosis and insulin resistance. Therefore, the cytokines concentration and the inflammation index have been thought to be the important factor to predict cardiovascular diseases. In addition, moderate exercise may increase anti-inflammation cytokines concentration and may reduce pro-inflammation cytokines concentration. The aim of this study was to investigate the effect of exercise before a high fat meal on cytokines concentrations and gene expression. Eight young male college students participated in this study. Subjects completed 2 experimental trials which were exercise trial (EX) and rest trial (RE). Subjects were asked to consume 75g glucose 30 min before either rest for 1 hour or exercise at 60%VO2max for 1 hour. Thereafter, subjects were asked to ingest oral fat tolerance meal (1.2 g/kg fat,1.1g /kg carbohydrate , and 0.33g/kg protein). Blood samples were collected for observing plasma CRP、TNF-α、IL-1α、IL-6、IL-8、IL-10 proteins and peripheral blood mononuclear cell (PBMC) mRNA during 6h postprandial period. After high fat meal, plasma CRP and IL-6 concentrations were significantly lower in EX. However, there were no significant difference in TNF-α, IL-1α, IL-8, the IL-10 protein and mRNA concentrations between trials. The current results suggested that exercise before the high fat meal did not alter cytokine concentrations.
URI: http://hdl.handle.net/11455/28025
其他識別: U0005-3006201016460900
文章連結: http://www.airitilibrary.com/Publication/alDetailedMesh1?DocID=U0005-3006201016460900
Appears in Collections:運動與健康管理研究所

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