Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/28033
標題: 不同運動介入時機對餐後脂肪代謝的影響
Effects of different exercise timing on postprandial lipemia
作者: 徐緯珍
Hsu, Wei-Chen
關鍵字: 運動介入時機
exercise timing
血脂肪
血糖
胰島素
postprandial lipemia
triglyceride
insulin
出版社: 運動與健康管理研究所
引用: 行政院衛生署(2012,7月20日)。歷年主要死亡原因死亡人數統計表。網址: http://www.doh.gov.tw/CHT2006/DM/DM2_2.aspx?now_fod_list_no=12336&class_no=440&level_no=4 美國運動醫學會健康體適能評估標準手冊(2008)。台北縣蘆洲市:易利圖書。 李若屏(2005)。運動對三大營養素代謝之影響。國民體育季刊。網址:http://www.sac.gov.tw/resource/annualreport/Quarterly148/p11.asp 郭家驊、劉昉青、祁業榮、劉珍芳、張振崗、郭婕(2001)。運動營養學。台中市:華格納。 楊璁人(2009)。不同碳水化合物與運動介入對脂肪耐受性之影響。未出版之碩士論文,國立台灣體育大學,台中市。 蕭寧馨(2006)。透視營養學。台北市:麥格羅希爾。(Wardlaw G. M., Hampl J.S.,& DiSilvestro R.A., 2004) Aldred, H. E., Perry, I. C., & Hardman, A. E. (1994). The effect of a single bout of brisk walking on postprandial lipemia in normo- lipidemic young adults. Metabolism, 43, 836–841. American College of Sports Medicine. (2010). ACSM''s Resource Manual for Guidelines for Exercise Testing and Prescription (6th Eds). New York: Wolters Kluwer. Braith R.W., & Stewart K. J. (2006). Resistance Exercise Training: Its Role in the Prevention of Cardiovascular Disease. Circulation, 113, 2642-2650. Burns S. F., Broom D. R., Miyashita M., Ueda, C., & Stensel D. J. (2006). Increased postprandial triacylglycerol concentrations following resistance exercise. Medicine & Science in Sports & Exercise, 38, 527-533. Davidson L. E., Hudson R., Kilpatrick K., Kuk J. L., McMillan K., Janiszewski P. M., Lee S., Lam M., Ross R. (2009). Effects of exercise modality on insulin resistance and functional limitation in older adults: a randomized controlled trial. Archives of Internal Medicine,169, 122-31. DeFronzo R. A., Gunnarsson R., Björkman O., Olsson M., & Wahren J. (1985). Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulindependent (type II) diabetes mellitus. The Journal of Clinical Investigation, 76, 149–155. Enkhman B., Ozturk Z., Anuurad E., & Berglund L. (2010). Postprandial lipoproteins and cardiovascular disease risk in diabetes mellitus. Current Diabetes Reports, 10, 61-69. Geluk C. A., Halkes C. J., de Jaegere P. P., Plokker T. W., & Cabezas M. C. (2004). Daytime triglyceridemia in normocholesterolemic patients with premature atherosclerosis and in their first-degree relatives. Metabolism, 53, 49-53. Gill J. M., Herd S. L., Hardman A. E. (2002). Moderate exercise and post-prandial metabolism: issues of dose-response. Journal of Sports Sciences, 20, 961-967. Gotto A. M. (1998). Triglyceride as a risk factor for coronary artery disease. American Journal of Cardiology, 82, 22-25. Grundy S. M., Brewer F. I. B., Cleeman J. I., Smith S. C., & Lenfant, C. (2004). Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientilic issues related to definetion. Circulation, 109, 433-8. Heath G. W., Gavin J. R., 3rd, Hinderliter J. M., Hagberg J. M.,Bloomfield S. A., & Holloszy J. O. (1983). Effects of exercise and lack of exercise on glucose tolerance and insulin sensitivity. Journal of Applied Physiology, 55, 512-517. Horowitz J. F., & Klein S. (2000). Oxidation of non-plasma fatty acids during exercise is increased in women with abdominal obesity. Journal of Applied Physiology, 89, 2276-2282. Hunter G. R., Bryan D. R., Wetzstein C. J., Zuckerman P. A., Bamman M. M. (2002). Resistance training and intraabdominal adipose tissue in older men and women. Medicine & Science in Sports & Exercise, 34, 1023–1028. Karpe F. (1999). Postprandial lipoprotein metabolism and atherosclerosis. International Journal of Sports Medicine, 246, 341–355. Katsanos C. S., Grandjean P. W., & Moffatt R. J. (2004). Effects of low and moderate exercise intensity on postprandial lipemia and postheparin plasma lipoprotein lipase activity in physically active men. Journal of Applied Physiology, 96, 181-188. Karpe F., Hellenius M. L., & Hamsten A. (1999). Differences in postprandial concentrations of very-low-density lipoprotein and chylomicron remnants between normotriglyceridemic and hypertriglyceridemic men with and without coronary heart disease. Metabolism, 48, 301-307. Kiens B., & Richter E. A. (1998). Utilization of skeletal muscle triacylglycerol during postexercise recovery in humans. American Journal of Physiology Endocrinology and Metabolism, 275, E332–E337. Kiens B., Gustavsson B. E., Christensen N. J., & Saltin B. (1993). Skeletal muscle substrate utilization during submaximal exercise in man: effect of endurance training. Journal of Physiology, 469, 459–478. Kiens B., Lithell H., Mikines K. J., and Richter E. A. (1989). Effects of insulin and exercise on muscle lipoprotein lipase activity in man and its relation to insulin action. The Journal of Clinical Investigation, 84, 1124–1129. Kolovou G. D., Anagnostopoulou K. K., Pavlidis A. N., Salpea K. D., Iraklianou S. A., Tsarpalis K., Damaskos D. S., Manolis A., & Cokkinos D. V. (2005). Postprandial lipemia in men with metabolic syndrome, hypertensives and healthy subjects. Lipids in Health and Disease, 4, 21-28. Lewis G. F., O’Meara N. M., Soltys P. A., Blackman J. D., Iverius P. H., Druetzler A. F., Getz G. S., & Polonsky K. S. (1990). Postprandial lipoprotein metabolismin normal and obese subjects: comparison after the vitamin A fat-loading test. Journal of Clinical Endocrinology Metabolism, 71, 1041–1050. Lithell H., Hellsing K., Lundqvist G., & Malmberg P. (1979). Lipoprotein-lipase activity of human skeletal-muscle and adipose tissue after intensive physical exercise. Acta Physiologica Scandinavica, 105, 312-5. Lopez-Candales A. (2002). Cardiovascular diseases: a review of the Hispanic Perspective . Awareness is the first step to action. Journal of Medicine, 33, 227– 45. Lteif A. A., Han K., & Mather K. J. (2005). Obesity, Insulin Resistance, and the Metabolic Syndrome - Determinants of Endothelial Dysfunction in Whites and Blacks. Circulation, 112, 32-38. Malkova D., Evans R. D., Frayn K. N., Humphreys S. M., Jones P. R., & Hardman A. E. (2000). Prior exercise and postprandial substrate extraction across the human leg. American Journal of Physiology Endocrinology and Metabolism, 279, E1020 – E1028. Miyashita M., Burns S. F.,& Stensel D. J. (2006). Exercise and postprandial lipemia: effect of continuous compared with intermittent activity patterns. American Journal of Clinical Nutrition, 83, 24–9. Mittendorfer B., Fields D. A., & Klein S. (2004). Excess body fat in men decreases plasma fatty acid availability and oxidation during endurance exercise. American Journal of Physiology Endocrinology and Metabolism, 286, E354–E362. Ntyintyane L. M., Panz V. R., Raal F. J.,& Gill G. V. (2008). Postprandial lipaemia, metabolic syndrome and LDL particle size in urbanised South African blacks with and without coronary artery disease. Quarterly Journal of Medicine, 101, 111-9. Ormsbee M. J., Thyfault J. P., Johnson E. A., Kraus R. M., Choi M. D., & Hickner R. C. (2007). Fat metabolism and acute resis- tance exercise in trained men. Journal of Applied Physiology, 102, 1767–1772. Oscai L. B., Essid D. A., & Palmer W. K. (1990). Lipase regulation of muscle triglyceride hydrolysis. Journal of Applied Physiology , 69, 1571–1577. Patsch J. R., Miesenbock G., Hopferwieser T., Muhlberger V., Knapp E., Dunn J. K., Gotto A. M., Jr., & Patsch W. (1992). Relation of triglyceride metabolism and coronary artery disease. Studies in the postprandial state. Arteriosclerosis, Thrombosis, and Vascular Biology, 12, 1336–1345. Petridou A., & Mougios V. (2002). Acute changes in triacylglycerol lipase activity of human adipose tissue during exercise. The Journal of Lipid Research, 43,1331-4. Petitt D. S. , & Cureton K. J. (2003). Effects of prior exercise on postprandial lipemia: a quantitative review. Metabolism, 52, 418–424. Perseghin G., Price T. B., Petersen K. F.,Roden M., Cline G.W., Gerow K., Rothman D. L., & Shulman G. I. (1996). Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. New England Journal of Medicine, 335, 1357–1362. Pfeiffer M., Ludwig T., Wenk C., & Colombani P. C. (2005). The influence of walking performed immediately before meals with moderate fat content on postprandial lipemia. Lipids in Health and Disease, 4, 24-32. Poehlman E. T., Dvorak R. V., DeNino W. F., Brochu M., & Ades P. A. (2000). Effects of resistance trainingand and endurance training on insulin sensitivity in nonobese, young, women: a controlled randomized trial. Journal of Clinical Endocrinology Metabolism, 85, 2463-2468. Powers S. K., & Howley E. T. (2001). Exercise physiology: theory and application and performance (4th ed.). N.Y. : McGraw-Hill Higher Education. Posner B., Franz M., & Quatromoni P. (1994). Nutrition and the global risk for chronic diseases: the INTERHEALTH Nutrition Initiative. Nutrition Reviews, 52, 210–7. Rabøl R., Petersen K. F., Dufour S., Flannery C., & Shulman G. I. (2011). Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals. Proceedings of the National Academy of Sciences,108, 13705-9. Riccardi G., Giacco R., & Rivellese A. A . (2004). Dietary fat, insulin sensitivity and the metabolic syndrome. Clinical Nutrition, 23, 447–456. Ross R., Rissanen J., Pedwell H., Clifford J., Shragge P. (1996). Influence of diet and exercise on skeletal muscle and visceral adipose tissue in men. Journal of Applied Physiology, 81, 2445–2455. Ross R., & Rissanen J. (1994). Mobilization of visceral and subcutaneous adipose tissue in response to energy restriction and exercise. American Journal of Clinical Nutrition, 60, 695–703. Scuteri A., Najjar S. S., Morrell C. H., & Lakatta E. G. (2005). The metabolic syndrome in older individuals: prevalence and prediction of cardiovascular events: the Cardiovascular Health Study. Diabetes care, 28, 882-7. Seip R. L., Angelopoulos T. J., & Semenkovich C. F. (1995). Exercise induces human lipoprotein lipase gene expression in skeletal muscle but not adipose tissue. American Journal of Physiology Endocrinology and Metabolism, 268, E229-E236. Short K. R., Pratt L. V., & Teague A. M. (2012). The acute and residual effect of a single exercise session on meal glucose tolerance in sedentary young adults. Journal of Nutrition and Metabolism, 2012,1-9. Shannon K. A., Shannon R. M., Clore J. N., Gennings C., Warren B. J., & Potteiger J. A. (2005). Resistance exercise and post- prandial lipemia: The dose effect of differing volumes of acute resistance exercise bouts. Metabolism, 54, 756-63. Singhal A., Trilk J. L., Jenkins N. T., Bigelman K. A., & Cureton K. J. (2009). Effect of intensity of resistance exercise on postprandial lipemia. Journal of Applied Physiology, 106, 823-9. Silvestre R., Kraemer W. J., Quann E. E., Seip R. L., Maresh C. M., Vingren J. L., Hatfield D. L., Volek J. S. (2008). Effects of exercise at different times on postprandial lipemia and endothelial function. Medicine & Science in Sports & Exercise, 40, 264-7. Smutok M. A., Kokkinos P. F., Farmer C., Dawson P., Shulman R., DeVane-Bell J., Patterson J., Charabogos C., Goldberg A. P., & Hurley B. F. (1993). Aerobic versus strength training for risk factor intervention in middle-aged men at high risk for coronary heart disease, Metabolism, 42, 177–184. Tsetsonis N. V., & Hardman A. E. (1996). Reduction in postprandial lipemia after walking: influence of exercise intensity. Medicine & Science in Sports & Exercise, 28, 1235–1242. Varady K. A., Bhutani S., Klempel M. C. and Kroeger M. C. (2011). Comparison of effects of diet versus exercise weight loss regimens on LDL and HDL particle size in obese adults. Lipids in Health and Disease, 10, 119-124. Weiss E. P., Arif H. , Villareal D. T., Marzetti E., and Holloszy J. O. (2008). Endothelial function after high-sugar-food ingestion improves with endurance exercise performed on the previous day. American Journal of Clinical Nutrition, 88, 51–57. Zhang J. Q., Ji L.L., Fogt D. L., & Fretwell V. S. (2007). Effect of exercise duration on postprandial hypertriglyceridemia in men with metabolic syndrome. Journal of Applied Physiology, 103, 1339–1345. Zhang J. Q., Thomas T. R., & Ball S. D. (1998). Effect of exercise timing on postprandial lipemia and HDL cholesterol subfractions. Journal of Applied Physiology, 85, 1516–1522.
摘要: 目的:近年來有許多學者於研究中發現,長期的血脂肪異常會造成動脈病變而引發心血管疾病,也容易導致糖尿病,而餐後血脂肪異常是提高罹患心血管疾病風險的指標之一,降低餐後血脂肪能有效降低罹患心血管疾病的風險,因此本研究主要目的在探討較佳的運動介入時機對於餐後脂肪代謝的影響。方法:本實驗以7名有規律運動的健康男性為受試對象,所有受試者須以隨機的方式完成四組實驗,分別為:運動後6小時進食 (EX-6hr)、運動後4小時進食 (EX-4hr)、運動後2小時進食 (EX-2hr) 及進食前不運動 (control)。除控制組外,在三組運動組中每人皆須在跑步機上進行為時45分鐘、強度為60VO2max的運動,在運動後分別於2、4及6小時給予高脂肪餐點 (OFTT),並於餐前及餐後30、90、150、210及270分鐘後採取血液進行分析,觀察餐後4小時間的血脂肪代謝、血糖及胰島素變化。所有數據均採重複量數二因子變異數分析法來進行比較,而AUC及IACU則採重複量數單因子變異數分析法進行分析。結果:本研究主要結果發現,在血漿中生化值部分四組皆無顯著差異 (p > .05),餐前6小時的運動介入,血脂肪略低於控制組,但是餐前2、4及6小時的運動介入對於胰島素曲線下增加面積皆略低於控制組。結論:本研究的結論為餐前不同的運動介入時機對於餐後血脂肪的變化皆無明顯的影響,但在餐前6小時的運動介入對於血脂肪、血糖及胰島素部分則有下降的趨勢。
Purpose: Recent studies show that hypertriglyceridemia is a potential risk factor for cardiovascular disease and diabetes. Therefore, lowering postprandial hyper- triglyceridemia after a fat-meal may prevent cardiovascular disease and atherogenic process. The aim of this study was to examine the optimal exercise timing on postprandial triglyceride (TG), total cholesterol (TC), insulin and glucose responses. Methods: 7 healthy, active male subjects were participated in this study. All subjects completed 4 experimental trials in a randomized order and cross- over design: 1) exercise at 6 hours before fat-meal (EX-6hr), 2) exercise at 4 hours before fat-meal (EX-4hr), 3) exercise at 2 hours before fat-meal (EX-2hr), and 4) No exercise before fat-meal (control). Except for control group, the rest of the groups were asked to exercise at 60% VO2max for 45 minutes before an oral fat tolerance test. Blood sample were collected before meal and 30, 90, 150, 210, 270 minutes after meal. All data were analyzed by repeated designed two-way ANOVA, AUC and IACU were analyzed by repeated designed one-way ANOVA. Results: There are no significant differences in TG, TC, insulin and glucose between trials (p > .05). Postprandial lipemia seems to slightly lower in the group of exercise at 6 hours before meal compared to the control group. The IAUC of exercise at 2, 4 and 6 hours before a meal were slightly lower than the control group. Conclusions: There were no significant effects on exercise before a fat-meal on postprandial lipemia, but it seems that exercise at 6 hours before fat-meal have a downward trend on postprandial lipemia, blood glucose and insulin.
URI: http://hdl.handle.net/11455/28033
其他識別: U0005-2908201211272500
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