Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/28088
標題: 耐力與阻力運動對於攝取高脂肪餐所引起免疫反應之影響
The Influence of Endurance and Resistance Exercise on High Fat Meal Induced Immune Response
作者: 詹文惠
Chan, Wen-Hui
關鍵字: 耐力運動
endurance exercise
阻力運動
餐後發炎反應
細胞激素
resistane exercise
postprandial inflammation
cytokines
出版社: 運動與健康管理研究所
引用: 王聖予、李麗俐、陳慧玲、馮潤蘭、楊志元、謝國珍(譯)(1996)。免疫學。台北市:藝軒圖書出版社。(Roitt, I. M., Brostoff, J., & Male, D. K., 1989) 行政院衛生署國民健康局(2008)。預防代謝症候群教學手冊。 徐嘉吟、方信智 (2006)。心血管疾病的新指標-高敏感性C-反應蛋白 (hs-CRP)。基層醫學,21(1),63-67。 高順生、趙樹林(2002)。運動免疫學。大陸北京:北京體育大學出版社。 高曉明(2007)。免疫學入門。台北縣新店市:藝軒圖書出版社。 陳琦華、蔡春玉、鄧新棠(2004)。代謝症候群的藥物治療。台灣臨床藥學雜誌,11(3),51-69。 陳惠英、顏國欽 (1998)。自由基、抗氧化防禦與人體健康。臺灣營養學會雜誌,23(1),105-121。 楊偉勛(2003)。由 adiponectin 到代謝症候群(metabolic syndrome)與冠狀動脈心臟病(coronary artery disease)。中華民國內分泌暨糖尿病會會訊,17(1),1-10。 葉振聲(1995)。第二型糖尿病致病機轉之現況與展望。臨床醫學月刊,36 卷4 期,243-247。 謝文欽(譯)(2004)。細胞與分子免疫學。臺北市:合記出版社(Abbas, A. K., & Lichtman A. H.) Abbasi, S. H., & Boroumand, M. A., (2010). Expanded network of inflammatory markers of atherogenesis: Where are we now? Open Cardiovasc Medicine Journal, 4, 38-44. Ahima, R. S., & Flier, J. S. (2000). Adipose tissue as an endocrine organ. Trends in Endocrinology and Metabolism, 11(8), 327-332. Akira, S., Taga, T. & Kishimoto, T. (1993). Interleukin-6 in biology and medicine. Advances in Immunology, 54, 1-78. Aljada, A., Mohanty, P., Ghanim, H., Abdo, T., Tripathy, D., Chaudhuri, A., & Dandona. P. (2004). Increase in intranuclear nucler factor-κB and decrease in inhibitor-κB in mononuclear cells after a mixed meal: evidence for a proinflammatory effect. American Journal of Clinical Nutrition, 79, 682-690. Alvarez, J. A., Higgins, P. B., Oster, R. A., Fernandez, J. R., Darnell, B. E., & Gower, B. A. (2009). Fasting and postprandial markers of inflammation in lean and overweight children. The American Journal of Clinical Nutrition, 89(4), 1138-1144. Andrei, I. M., Roy, J. S., & Pang, N. S. (2000). Exercise elevates plasma levels but not expression of IL-β, IL-6, and TNF-α in blood mononuclear cells. Journal of Applied Physiology, 89, 1499-1504. Arvidsson, E., Viguerie, N., Andersson, I., Verdich, C., Langin, D., & Arner, P. (2004). Effects of different hypocaloric diets on protein secrerion from adipose tissue of obese women. Diabetes , 53, 1966-1971. Baechle, T. R., & Earle, R. W. (2011). Weight training: steps to success: Human Kinetics. Baggiolini, M., Loetscher, P. & Moser, B. (1995). Interleukin 8 and the chemokine family. International Journal of Immunopharmacology, 17(2), 103-108. Baggiolini, M. & Clark-Lewis, I. (1992). Interleukin 8, a chemotactic and inflammatory cytokine. FEBS Letters, 307(1), 97-101. Balducci, S., Zanuso, S., Nicolucci, A., Fernando, F., Cavallo, S., Cardelli, P., et at. (2010). Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss. Nutrition, Metabolism, and Cardiovascular Diseases, 20(8), 608-607. Barzilay, J. I., Abraham, L., Heckbert, S. R., Cushman, M., Kuller, L. H., Resnick, H. E., & Tracy, R. P. (2001). The relation of markers of inflammation to the development of glucose disorders in the elderly: the Cardiovascular Health Study. Diabetes, 50, 2384-2389. Bassuk, S. S., Rifai, N., & Ridker, P. M. (2004). High-sensitivity C-reactive protein: clinical importance. Current Problems in Cardiology, 29(8), 439-493. Bastard, J. P., Jardel, C., Bruckert, E., Blondy, P., Capeau, J., Laville, M., et al. (2000). Elevated level of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. Journal of Clinical Endocrinology and Metabolism, 85, 3338-3342. Bebo, B.F. Jr., Schuster, J. C., Vandenbark, A. A., & Offner, H. (1999). Androgens alter the cytokine profile and reduce encephalitogenicity of myelin-reactive T cells. Journal of Immunology, 162, 35-40. Blackburn, P., Despres, J. P., Lamarche, B., Tremblay, A., Bergeron, J., Lemieux, I., & Couillard, C. (2006). Postprandial variations of plasma inflammatory markers in abdominally obese men. Obesity(Silver Spring), 14(10), 1747-1754. Brooks, N., Layne, J. E., Gordon, P. L., Roubenoff, R., Nelson, M. E., & Castaneda-Sceppa, C. (2007). Strength training improves muscle quality and insulin sensitivity in Hispanic older adults with type 2 diabetes. International Journal of Sports Medicine, 4, 19-27. Bruunsgaard, H., Galbo, H., Halkjaer-Kristensen, J., Johansen, T. L., MacLean, D. A., & Pedersen, B. K. (1997). Exercise-induced increase in serum interleukin-6 in humans is related to muscle damage. The Journal of Physiology, 15(3), 833-841. Buford, T.W., Cooke, M.B., & Willoughby, D.S. (2009). Resistance exerciseinduced changes of inflammatory gene expression within human skeletal muscle. European Journal of Applied Physiology, 107, 463-471. Burns, S. F., Broom, D. R., Miyashita, M., Ueda, C., & Stensel, D. J. (2006). Increased postprandial triacylglycerol concentrations following resistance exercise. Medicine and Science in Sports Exercise, 38(3), 527-533. Calabro, P., Willerson, J. T., & Yeh, E. T. (2003). Inflammatory cytokines stimulated C-reactive protein production by human coronary artery smooth muscle cells. Circulation, 108(16), 1930-1932. Cani, P. D., Amar, J., Iglesias, M. A., Poqqi, M. Knauf, C. Bastelica, D., et al.(2007). Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes, 56, 1761-1772. Carroll, M., & Schade, D. (2003). Timing of antioxidant vitamin ingestion alters postprandial proatheroegnic serum markers. Circulation, 108, 24-31. Castelli, W. P. (1996). Lipids, risk factors and ischaemic heart disease. Atherosclerosis, 124, S1-9. Chen, H. (2006). Cellular inflammatory responses: novel insinghts for obesity and insulin resistance. Pharmacological Research: the Official Journal of the Italian Pharmacological Society, 53, 469-477. Clement, K., Viguerie, N., Poitou, C., Carette, C., Pelloux, V., Curat, C. A., et al. (2004). Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects. FASEB Journal, 18, 1657-1669. Coussens, L. M., & Werb, Z. (2002). Inflammation and cancer. Nature ,420, 860-867. D’Agostino, P., Milano, S., Barbera, C., Di, B. G., La, R. M., Ferlazzo, V., et al. (1999). Sex hormones modulate inflammatory mediators produced by macrophages. Annals of the New York Academy Sciences, 876, 426-429. Dasu, M. R., & Jialal, I. (2011). Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors. American journal of physiology. Endocrinology and Metabolism, 300(1), E145-154. Deng,Y., & Scherer, P. E. (2010). Adipokines as novel biomarkers and regulators of the metabolic syndrome. Annals of the New York Academy of Sciences, 1212, 1-19. Despres, J. P., Lemieux, I., Bergeron, J., Pibarot, P., Mathieu, P., Larose, E., et al. (2008). Abdominal Obesity and the Metabolic Syndrome: Contribution to Global Cardiometabolic Risk. Arteriosclerosis , Thrombosis, and Vascular Biology, 28(6), 1039-1049. Di Napoli, M., Schwaninger, M., Cappelli, R., Ceccarelli, E., Di Gianfilippo, G., Donati, C., et al. (2005). Evaluation of C-reactive protein measurement for assessing the risk and prognosis in ischemic stroke: a statement for health care professionals from the CRP Pooling Project members. Stroke, 36(6), 1316-1329. Dohi, Y., Takase, H., Sato, K., & Ueda, R. (2007). Association among C-reactive protein, oxidative stress, and traditional risk factors in healthy Japanese subjects. International Journal of Cardiology, 115(1), 63-66. Duncan, B. B., Schmidt, M. I., Pankow, J. S., Ballantyne, C. M., Couper, D., Vigo, A., et al. (2003). Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study. Diabetes, 52, 1799-1805. Duvnjak, L., & Duvnjak, M. (2009). The metabolic syndrome - an ongoing story. Journal of Physiology and Pharmacology, 60 (Suppl 7), 19-24. Eisenhardt, S. U., Thiele, J. R., Bannasch, H., Stark, G. B., & Peter, K. (2009). C-reactive protein: How conformational changes influence inflammatory properties. Cell Cycle, 8, 3885-3892. Espinola-Klein, C., Gori, T., Blankenberg, S., & Munzel, T. (2011). Inflammatory markers and cardiovascular risk in the metabolic syndrome. Frontiers in Bioscience, 16, 1663-1674. Evans, W. J., Meredith, C. N., Cannon, J. G., Dinarello, C. A., Frontera, W. R., Hughes, V. A., et al. (1986). Metabolic changes following eccentric exercise in trained and untrained men. Journal of Applied Physiology, 61, 1864-1868. Fernandez-Real, J.M., & Ricart, W. (2003). Insulin resistance and chronic cardiovascular inflammatory syndrome. Endocrine Reviews, 24, 278-301. Ferreira, A. C., Peter, A. A., Mendez, A. J., Jimenez, J. J., Mauro, L. M., Chirinos, J. A., et al. (2004). Postprandial hypertriglyceridemia increases circulating levels of endothelial cell microparticles. Circulation, 110, 3599-3603. Festa, A., D’Agostino, R. Jr., Tracy, R. P., & Haffner, S. M. (2002). Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the insulin resistance atherosclerosis study. Diabetes, 51, 1131-1137. Ford, E. S. (2002). Does exercise reduce inflammation? Physical activity and C-reactive protein among U.S. adults. Epidemiology, 13(5), 561-568. Friedman, G. D., Klatsky, A. L., & Siegelaub, A.B. (1974). The leukocyte count as a predictor of myocardial infarction. The New England Journal of Medicine, 290, 1275-1278. Fruebis, J., Tsao, T. S., Javorschi, S., Ebbets-Reed, D., Erickson, M. R., Yen, F. T., et al. (2001). Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increase fatty acid oxidation in muscle and causes weight loss in mice. Proceeding of the National Academy of Sciences of the United States of America, 98(4), 2005-2010. Gabriel, H., & Kindermann, W. (1997). The acute immune response to exercise: what does it mean? Institute of Sports and Preventive Medicine, 18, 28-45. Gerhardt, C. C., Romero, I. A., Cancello, R., Camoin, L., & Strosberg, A. D. (2001). Chemokines control fat accumulation and leptin secretion by cultured human adipocytes. Molecular and Cellular Endocrinology, 175(1-2), 81-92. Giannattasio, C., Zoppo, A., Gentile, G., Failla, M., Capra, A., Maggi, F.M., et al. (2005). Acute effect of high-fat meal on endothelial function in moderately dyslipidemic subjects. Arteriosclerosis, Thrombosis, and Vascular Biology, 25, 406-410. Gielen, S., Adams, V., & Linke, A. (2005). Exercise training in chronic heart failure: Correlation between reduced local inflammation and improved oxidative capacity in the skeletal muscle. European Journal of Cardiovascular Prevention and Rehabilitation, 12(4), 393-400. Gill, J., Al-Mamari, A., Ferrell, W., Cleland, S., Packard, C., Sattar, N., Petrie, J., & Caslake, M. (2004) . Effects of prior moderate exercise on postprandial metabolism and vascular function in lean and centrally obese men. Journal of the American College Cardiology, 44, 2375-2382. Gleeson, M. (2007). Immune function in sport and exercise. Journal of Applied Physiology, 103(2), 693-699. Gleeson, M., McFarlin, B., & Flynn, M. (2006). Exercise and Toll-like receptors, Exercise Immunology Review, 12, 34-53. Grimble, R. F. (2002). Inflammatory status and insulin resistance. Current Opinion in Clinical Nutrition and Metabolic Care, 5(5), 551-559. Gupta, M., Singh, N., & Verma, S. (2006). South Asians and cardiovascular risk: what clinicians should know. Circulation, 113, 924-929. Hackam, D. G., & Anand, S. S. (2003). Emerging risk factors for atherosclerotic vascular disease: a critical review of the evidence. The Journal of the American Medical Association, 290(7), 932-940. Hambrecht, R., Walther, C., & Mobius-Winkler, S. (2004). Percutaneous coronary angioplasty compared with exercise training in patients with stable coronary artery disease: A randomized trial. Circulation, 109(11), 1371-1378. Hardman, A. E. (1998). The influence of exercise on postprandial triacylglycerol metabolism. Atherosclerosis, 141(1), S93-100. Harrison, M., Murphy, R. P., O''Connor, P. L., O''Gorman, D. J., McCaffrey, N., Cummins, P. M., & Moyna, N. M. (2009). The endothelial microparticle response to a high fat meal is not attenuated by prior exercise. European Journal of Applied Physiology, 106(4), 555-562. Heinrich, P. C., Castell, J.V., & Andus, T. (1990). Interleukin-6 and the acute phase response. The Biochemical Journal, 265, 621-636. Hellsten, Y., Frandsen, U., Orthenblad, N., Sjodin, N., & Richter, E. A. (1997). Xanthine oxidase in human skeletal muscle following eccentric exercise: a role in inflammation. The Journal of Physiology, 498, 239-248. Hibi, M., Nakajima, K., & Hirano, T. (1996). IL-6 cytokine family and signal transduction: a model of the cytokine system. Journal of Molecular Medicine, 74, 1-12. Hirano, T., Matsuda, T., & Nakajima, K. (1994). Signal transduction through gp130 that is shared among the receptors for the interleukin 6 related cytokine subfamily. Stem Cells, 12, 262-277. Hirose, L., Nosaka, K., Newton, M., Laveder, A., Kano, M., Peake, J., et al. (2004). Changes in inflammatory mediators following eccentric exercise of the elbow flexors. Exercise Immunology Review, 10, 75-90. Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F ,& Spiegelman, B. M. (1996). IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science, 271(5249), 665-668. Hotamisligil, G. S. (1999). Mechanisms of TNF-alpha-induced insulin resistance. Experimental and Clinical Endocrinology & Diabetes, 107(2), 119-125. Igarashi, M., Hirata, A., & Yamauchi, T. (2003). Clinical utility and approach to estimate postprandial hypertriglycemia by a newly designed oral fat-loading test. Journal of Atherosclerosis and Thrombosis, 10, 314-320. Isasi, C. R., Deckelbaum, R. J., Tracy, R.P., Starc, T. J., Berglund, l., & Shea, S. (2003). Physical fitness and C-reactive protein level in children and young adults: the Columbia University BioMarkers Study. Pediatrics, 111(2), 332-338. Jabs, W. J., Theissing, E., Nitschke, M., Bechtel, J. F., Duchrow, M., Mohamed, S., et al. (2003). Local generation of C-reactive protein in diseased coronary artery venous bypass grafts and normal vascular tissue. Circulation, 108(12), 1428-1431. Jellema, A., Plat, J., & Mensink, R. P. (2004). Weight reduction, but not a moderate intake of fish oil, lowers concentrations of inflammatory markers and PAI-1 antigen in obese men during the fasting and postprandial state. European Journal of Clinical Investigtion, 34, 766-773. Johnston, A. P., De Lisio, M., & Parise, G. (2008). Resistance training, sarcopenia, and the mitochondrial theory of aging. Applied Physiology, Nutrition, and Metabolic, 33, 191-199. Kadoglou, N. P., Iliadis, F., Angelopoulou, N., Perrea, D., Ampatzidis, G., Liapis, C. D., et al. (2007). The anti-inflammatory effects of exercise training in patients with type 2 diabetes mellitus. European Journal of Cardiovascular Prevention and Rehabilitation, 14(6), 837-843. Keller, C., Keller, P., Giralt, M., Hidalgo, J., & Pedersen, B. K. (2004). Exercise normalizes overexpression of TNF-alpha in knockout mice. Biochemical and Biophysical Research Communications, 321, 179-182. Kendall, D. M. (2005). The Truth about Lipid Effects of the Thiazolidinediones. Metabolic Syndrome and Related Disorders, 3(3), 194-197. Kershaw, E.E., & Flier, J. S. (2004). Adipose tissue as an endocrine organ. Journal of Clinical Endocrinology and Metabolism, 89(6), 2548-2556. Kobashi, C., Asamizu, S., Ishiki, M., Iwata, M., Usui, I., Yamazaki, K., et al. (2009). Inhibitory effect of IL-8 on insulin action in human adipocytes via MAP kinase pathway. Journal of Inflammation, 6, 25-30. Lagathu, C., Yvan-Charvet, L., Bastard, J. P., Maachi, M., Quignard-Boulange, A., Capeau, J., et al. (2006) Longterm treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes. Diabetologia, 49, 2162-2173. Lakka, T. A., Lakka, H. M., Rankinen, T., Leon, A. S., Rao, D. C., Skinner, J., et al. (2005). Effect of exercise training on plasma levels of C-reactive protein in healthy adults: the HERITAGE Family Study. European Heart Journal, 26(19), 2018-2025. Lang, R., Patel, D., Morris, J. J., Rutschman, R. L., & Murray, P. J. (2002). Shaping gene expression in activated and resting primary macrophages by IL-10. Journal of Immunology, 169, 2253-2263. Lau D. C., Dhillon B., Yan H., Szmitko P. E., & Verma S. (2005). Adipokines: molecular links between obesity and atheroslcerosis. American Journal Physiology . Heart Circulatory Physiology, 288, 2031-2041. Leopold, J. A., & Loscalzo, J. (2008). Oxidative mechanisms and atherothrombotic cardiovascular disease. Drug Discovery Today: Therapeutic Strategies, 5(1), 5-13. Levinger, I., Goodman, C., Peake, J., Garnham, A., Hare, D.L., Jerums, G., & Selig, S. (2009). Inflammation, hepatic enzymes and resistance training in individuals with metabolic risk factors. Diabetic medicine: a Journal of the British Diabetic Association, 26(3), 220-227. Libby, P. (2000). Changing concepts of atherogenesis. Journal of Internal Medicine, 247, 349-358. Libby, P., Ridker, P. M., & Maseri, A. (2002). Inflammation and atherosclerosis. Circulation, 105, 1135-1143. Loppnow, H., Werdan, K., Reuter, G., & Flad, H. D. (1998). The interleukin-1 and interleukin-1 converting enzyme families in the cardiovascular system. European Cytokine Network, 9(4), 675-680. Lottenberg, A. M., Afonso, M. S., Lavrador, M. S. F., Machado, R. M., & Nakandakare, E. R. (2012). The role of dietary fatty acids in the pathology of metabolic syndrome. The Journal of Nutritional Biochemistry, 27(6), 27-35. Lundman, P., Boquist, S., Samnegard, A., Bennermo, M., Held, C., Ericsson, C. G., et al. (2007). A high-fat meal is accompanied by increased plasma interleukin-6 concentrations. Nutrition, Metabolism and Cardiovascular Diseases, 17(3), 195-202. MacEneaney, O. J., Harrison, M., O''Gorman, D. J., Pankratieva, E. V., O''Connor, P. L., & Moyna, N.M. (2009). Effect of prior exercise on postprandial lipemia and markers of inflammation and endothelial activation in normal weight and overweight adolescent boys. European Journal of Applied Physiology, 106, 721-729. MacIntyre, D. L., Sorichter, S., Mair, J., Berg, A., & McKenzie, D. C. (2001). Markers of inflammation and myofibrillar protein following eccentric exercise in humans. European Journal of Applied Physiology, 84, 180-186. Malsuzawa, Y. (2010). Establishment of a concept of visceral fat syndrome and discovery of adiponectin. Proceedings of the Japan Academy. Series B, Physical and Biological Sciences, 86(2), 131-141. Mathur, N., & Pedersen B. K. (2008). Exercise as a mean to control low-grade systemic inflammation. Mediators of Inflammation, 2008, 10950. Mattusch, F., Dufaux, B., Heine, O., Mertens, I., & Rost, R. (2000). Reduction of the plasma concentration of C-reactive protein following nine months of endurance training. International Journal of Sports Medicine, 21(1), 21-24. McCarthy, D.A., & Dale, M. M. (1998). The leucocytosis of exercise. A review and model. Sports Medicine , 6(6), 333-363. Mohamed-Ali, V., Goodrick, S., Rawesh, A., Katz, D. R., Miles, J. M., Yudkin, J. S., et al. (1997). Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. Journal of Clinical Endocrinology and Metabolism, 82, 4196-4200. Mohanty, P., Ghanim, H., Hamouda, W., Aljada, A., Garg, R., & Dandona, P. (2002). Both lipid and protein intakes stimulate increased generation of reactive oxygen species by polymorphonuclear leukocytes and mononuclear cells. The American Journal of Clinical Nutrition, 75, 767-772. Moldoveanu, A. I., Shephard, R. J., & Shek, P. N. (2002). Exercise elevates plasma levels but not gene expression of IL-1beta, IL-6, and TNF-alpha in blood mononuclear cells. Journal of Applied Physiology, 89(4), 1499-1504. Molavi, B., Rasouli, N., & Kern, P. A. (2006). The prevention and treatment of metabolic syndrome and high-risk obesity. Current Opinion Cardiology, 21(5), 479-485. Moraes, R. C., Blondet, A., Birkenkamp-Demtroeder, K., Tirard, J., Orntoft, T. F., Gertler, A., et al. (2003). Study of the alteration of gene expression in adipose tissue of diet-induced obese mice by microarray and reverse transcription-polymerase chain reaction analyses. Endocrinology. 144, 4773-4782. Mucci, P., Durand, F., Lebel, B., Bousquet, J., & Prefaut, C. (2000). Interleukins 1-beta, -8, and histamine increases in highly trained, exercising athletes. Medicine and Science in Sports and Exercise, 32(6), 1094-1100. Murray, P. J. (2006). Understanding and exploiting the endogenous interleukin-10/STAT3-mediated anti-inflammatory response. Current Opinion in Pharmacology, 6, 379-386. Nappo, F., Esposito, K., Cioffi, M., Giugliano, G., olinari, A. M., Paolisso, G., et al. (2002). Postprandial endothelial activation in healthy subjects and in type 2 diabetes patients: role of fat and carbohydrate meals. Journal of the American College of Cardiology, 39(7), 1145-1150. Nieman, D. C. (1994). Exercise, infection, and immunity. International Journal of Sports Medicine, 15, 131-141. Nieman, D. C., Henson, D. A., Austin, M. D., & Brown, V. A. (2005). Immune response to a 30-minute walk. Medicine and Science in Sports and Exercise, 37(1), 57-62. Nonogaki, K., Fuller, G. M., Fuentes, N. L., Moser, A. H., Staprans, I., Grunfeld, C., & Feingold, K. R. (1995). Interleukin-6 stimulates hepatic triglyceride secretion in rats. Endocrinology, 136(5), 2143-2149. Ohshita, K., Yamane, K., Hanafusa, M., Mori, H., Mito, K., & Okubo M., et al. (2004). Elevated white blood cell count in subjects with impaired glucose tolerance. Diabetes Care, 27, 491–496. O''Keefe, J. H., Gheewala, N. M., & O''Keefe, J. O. (2008). Dietary strategies for improving post-prandial glucose, lipids, inflammation, and cardiovascular health. Journal of the American College of Cardiology, 51, 249-255. Okita, T., Nishijima, H., Murakami, T., Nagai, T., Morita, N., Yonezawa, K., et al. (2004). Can exercise training with weight loss lower serum C-reactive protein levels? Journal of American College of Cardiology, 44, 2411-2413. Oliveira, M., & Gleeson, M. (2010). The influence of prolonged cycling on monocyte Toll-like receptor 2 and 4 expression in healthy men. European Journal of Applied Physiology, 106(2), 251-257. Ostrowski, K., Rohde, T., Zacho, M., Asp, S., & Pedersen, B. K. (1998). Evisence that interleukin-6 is produced in human skeletal muscle during prolonged running. Journal of Physiology, 508, 949-953. Ostrowski, K., Rohde, T., Asp, S., Schjerling, P., & Pedersen, B. K. (1999). Pro- and anti-inflammatory cytokine balance in strenuous exercise in humans. Journal of Physiology, 515, 287-291. Ostrowski, K., Rohde, T., Asp, S., Schjerling, P., & Pedersen, B. K. (2001). Chemokines are elevated in plasma after strenuous exercise in humans. European Journal of Applied Physiology, 84(3), 244-245. Pasceri, V., Willerson, J. T., & Yeh, E. T. (2000). Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation, 102(18), 2165-2168. Payette, C., Blackburn, P., Lamarche, B., Tremblay, A., Bergeron, J., Lemieux, I., et al. (2009). Sex differences in postprandial plasma tumor necrosis factor–α, interleukin-6, and C-reactive protein concentrations. Metabolism, 58(11), 1593-1601. Peake, J. M., Nosaka, K., Muthalib, M., & Suzuki, K. (2006). Systemic inflammatory responses to maximal versus submaximal lengthening contractions of the elbow flexors. Exercise Immunology Review, 12, 72-85. Pearson, T. A., Mensah, G. A., Alexander, R. W., Anderson, J. L., Cannon III, R. O., Criqui, M., et al. (2003). Markers of inflammation and cardiovascular disease application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and American Heaet Association. Circulation, 107, 499-511. Pedersen, B. K., Bruunsgaard, H., Jensen, M., Toft, A. D., Hansen, H., & Ostrowski, K. (1999). Exercise and the immune system - Influence of nutrition and ageing. Journal of Science and Medicine in Sport, 2(3), 234-252. Pedersen, B. K. & Febbraio, M. A. (2008). Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiological Reviews, 88, 1379-1406. Pedersen, B. K., Hoffman-Goetz, L., Rogers, C. J., Northoff, H., Abbasi, A., Simon, P. et al. (2001). Position statement. Part one: Immune function and exercise. Exercise immunology review, 17, 6-63. Pedersen, B. K., Rohde, T., & Zacho, M. (1996). Immunity in athletes. The Journal of Sports Medicine Physical Fitness, 36(4), 236-245. Pedersen, B. K., Steensberg, A., Fischer, C., Keller, C., Keller, P., Plomgaard, P., et al. (2004). The metabolic role of il-6 produced during exercise: Is il-6 an exercise factor? The Proceedings of Nutrition Society, 63, 263-267. Pedersen, B. K., & Toft, A. D. (2000). Effects exercise on lymphocytes and cytokines. British Journal of Sports Medicine, 34 (4), 246-251. Pepys, M. B., & Balz, M. L. (1983). Acute phase proteins with special reference to C-reactive protein and related proteins (pentaxins) and serum amyloid a protein. Advances in Immunology, 34, 141-212. Petersen, A. M., Pedersen, B. K. (2005). The anti-inflammatory effect of exercise. Journal of Applied Physiology, 98(4), 1154-1162. Phillips, M. D., Patrizi, R. M., Cheek, D. J., Wooten, J. S., Barbee, J. J., & Mitchell, J. B. (2012). Resistance training reduces subclinical inflammation in obese, postmenopausal women. Medicine and Science in Sports and Exercise, 44(11), 2099-2110. Pickup, J. C. & Crook, M. A. (1998). Is type II diabetes mellitus a disease of the innate immune system? Diabetologia, 41, 1241-1248. Plotnick, G. D., Corretti, M. C., & Vogel, R.A. (1997). Effect of antioxidant vitamins on the transient impairment of endothelium-dependent brachial artery vasoactivity following a single high-fat meal. The Journal of the American Medical Association, 278, 1682-1686. Poppitt, S. D., Keogh, G. F., Lithander, F. E., Wang, Y., Mulvey, T. B., Chan, Y. K., et al. (2008). Postprandial response of adiponectin, interleukin-6, tumor necrosis factor-alpha, and C-reactive protein to a high-fat dietary load. Nutrition, 24(4), 322-329. Powers, S. K., Ji, L. L., & Leeuwenburgh, C. (1999). Exercise training-induced alteration in skeletal muscle antioxidant capacity: a brief review. Medicine and Science in Sports and Exercise, 31, 987-997. Pradhan, A. D., Manson, J. E., Rifai, N., Buring, J.E. & Ridker, P.M. (2001). C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. The Journal of the American Medical Association, 286, 327-324. Przybyla, B., Gurley, C., Harvey, J. F., Bearden, E., Kortebein, P., Evans, W. J., et al. (2006). Aging alters macrophage properties in human skeletal muscle both at rest and in response to acute resistance exercise. Experimental Gerontology, 41(3), 320-327. Ramadori, G. & Christ, B. (1999). Cytokines and the hepatic acute-phase response. Seminars in Liver Disease, 19(2), 141-155. Rajala, M. W., & Scherer P. E. (2003). Minireview: The adipocyte—at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology, 144(9), 3765-3773. Ridker, P. M. (2003). Clincal application of C-reactive protein for cardiovascular disease detection and prevention. Circulation, 107, 363-369. Rifai, N., Joubran, R., Yu, H., Asmi, M., & Jouma, M. (1999). Inflammatory markers in the men angiographically documented coronary heart disease. Clinical Chemistry, 45(11), 1967-1973. Ross, R. (1999). Atherosclerosis-- an inflammatory disease. The England Journal of Medicine, 340(2), 115-126. Rothwell, N., Allan, S., & Toulmond, S. (1997). The role of interleukin 1 in acute neurodegeneration and stroke: pathophysiological and therapeutic implications. The Journal of Clinical Investigation, 100(11), 2648-2652. Rubin, D. A., & Hackney, A.C. (2010). Inflammatory cytokines and metabolic risk factors during growth and maturation: influence of physical activity. Medicine and Sports Science, 55, 43-55. Ruan, H. & Lodish, H. F. (2003). Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-alpha. Cytokine & Growth Factor Reviews, 14(5), 447-455. Sabatine, M. S., Morrow, D. A., Cannon, C. P., Murphy, S. A., Demopoulos, L. A, DiBattiste, P.M., et al. (2002). Relationship between baseline white blood cell count and degree of coronary artery disease and mortality in patients with acute coronary syndromes: a TACTICS-TIMI 18 substudy. Journal of American College of Cardiology, 40, 1761-1768. Sattar, N., Gaw, A., Scherbakova, O., Ford, I., O’Reilly, D. S., Haffner, S. M., et al. (2003). Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland Coronary Prevention Study. Circulation, 108(4), 414-419. Senn, J. J., Klover, P. J., Nowak, I. A., & Mooney, R. A. (2002). Interleukin-6 induces cellular insulin resistance in hepatocytes. Diabetes, 51(12), 3391-3399. Sheikholeslami Vatani, D., Ahmadi, S., Ahmadi Dehrashid K,. & Gharibi, F. (2011). Changes in cardiovascular risk factors and inflammatory markers of young, healthy, men after six weeks of moderate or high intensity resistance training. The Journal of Sports Medicine Physical Fitness, 15(4), 695-700. Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H & Flier, J.S. (2006). TLR4 links innate immunity and fatty acid-induced insulin resistance. The Journal of Clinical Investigtion, 116(11), 3015-3025. Shoelson, S. E., Herrero, L., & Naaz, A. (2007). Obesity, inflammation, and insulin resistance. Gastroenterology, 132, 2169-2180. Siegrist, M. (2008). Role of physical activity in the prevention of osteoporosis. Medizinische Monatsschrift fur Pharmazeuten, 31(7), 259-264. Smith, L. L. (2000). Cytokine hypothesis of overtraining: a physiological adaptation to excessive stress? Medicine and Science in Sports and Exercise, 32(2), 317-331. Steensberg, A., Fischer, C. P., Keller, C., Moller, K., & Pedersen, B. K. (2003). IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans. American Journal of Physiology. Endocrinology and Metabolism, 285(2), E433-437. Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., et al. (2001). The hormone resistin links obesity to diabetes. Nature, 409(6818), 307-312. Suzuki, K., H. Hasegawa, T. Endo, H. Sato, T. Koie, K. J. Suzuki, S., et al. (1996). Effect of maximal exercise on blood leukocyte counts, cytokine leaves and netrophil chemilumi -nescence. Journal Physical Fitness Nutrition Immunology, 6, 123-130. Suzuki, K., Nakaji, S., Yamada, M., Totsuka, M., Sato, K., & Sugawara, K. (2002). Systemic inflammatory response to exhaustive exercise. Cytokine kinetics. Exercise Immunology Review, 8, 6-48. Takarada, Y., Nakamura, Y., Aruga, S., Onda, T., Miyazaki, S., & Ishii, N. (2000). Rapid increase in plasma growth hormone after low-intensity resistance exercise with vascular occlusion. Journal of Applied Physiology, 88, 61-65. Takahashi, M. (2011). Inflammatory cytokines in the pathogenesis of atherosclerosis. Nippon Rinsho, 69, 30-33. Tam, C. S., Viardot, A., Clement, K., Tordjman, J., Tonks, K., Greenfield, J. R., et al. (2010). Short-term overfeeding may induce peripheral insulin resistance without altering subcutaneous adipose tissue macrophages in humans. Diabetes, 59, 2164-2170. Tsai, W., Li, Y., Lin, C., Chao, T., & Chen J. (2004). Effects of oxidative stress on endothelial function after a high-fat meal. Clinical Science, 106, 315-319. Tsigos, C., Papanicolaou, D. A., Kyrou, I., Defensor, R., Mitsiadis, C. S., & Chrousos, G. P. (1997). Dose-dependent effects of recombinant human interleukin-6 on glucose regulation. The Journal of Clinical Endocrinology & Metabolism, 82(12), 4167-4170. Uchida, M. C., Crewther, B. T., Ugrinowitsch, C., Bacurau, R. F, Moriscot, A. S., & Aoki, M. S. (2009). Effect of bench press exercise intensity on muscle soreness and inflammatory mediators. Journal of Sports Science, 27(5), 499-507. van Hall, G., Steensberg, A., Sacchetti, M., Fischer, C., Keller, C., Schjerling, P., et al. (2003). Interleukin-6 stimulates lipolysis and fat oxidation in humans. The Journal of Clinical Endocrinology and Metabolism, 88, 3005-3010. van Oostrom, A. J., Sijmonsma, T. P., Verseyden, C, Jansen, E. H., de Koning, E. J., Rabelink T. J., et al. (2003). Postprandial recruitment of neutrophils may contribute to endothelial dysfunction. Journal Lipid Research, 44, 576-583. van Oostrom, A. J., van Wijk, J. P., Sijmonsma, T. P., Rabelink, T. J., & Castro Cabezas, M. (2004). Increased expression of activation markers on monocytes and neutrophils in type 2 diabetes. The Netherlands Journal of Medocine, 62, 320-325. Van-Wijk, J. P., Cabezas, M. C., Coll, B., Joven, J., Rabelink, T
摘要: 餐後高血脂的狀態,容易引起全身性的低程度發炎反應,若長期處於這種狀態可能造成體內的慢性發炎,進而會增加得到慢性疾病的風險。過去研究發現適度運動可能會促使體內抗發炎細胞激素增加,使得促發炎之細胞激素減少。本研究的目的在探討耐力與阻力運動的介入對於攝取高脂肪餐後所引起的免疫反應及細胞激素的變化。本實驗以6名有運動習慣的健康男性為受試者,平均年齡為21.7 ± 0.6歲,平均身高為173.3 ± 2.3公分,平均體重為68.6 ± 3.1公斤。採交叉隨機實驗設計,所有受試者分別完成控制試驗(C)、耐力運動試驗(EE)及阻力運動試驗(RE),共三次試驗,每次試驗間隔一周,阻力運動試驗間隔兩周。實驗第一天下午進行耐力運動試驗以50%VO2max之強度於跑步機跑步1小時;阻力運動試驗使用啞鈴或槓鈴以80% 1RM進行10個動作,每個動作重複10-12下,需完成兩組,時間也是1小時;控制試驗則安靜休息1小時,結束後攝取晚餐並禁食14 小時。第二天早上至實驗室於前臂靜脈放置留滯針及進行口服脂肪耐受性試驗餐(1.2 g/kg 脂肪,1.1 g/kg碳水化合物,0.33 g/kg蛋白質),收集空腹及餐後連續6小時的血液樣本,分析血液中白血球、淋巴球、嗜中性球的含量,和血漿中發炎指標C-反應蛋白(CRP)及細胞激素腫瘤壞死因子(TNF-α)、介白素-1β(IL-1β)、介白素-6(IL-6)、介白素-8(IL-8)、介白素-10(IL-10)。結果顯示,白血球、淋巴球、嗜中性球各組別與各時間點上無顯著改變,IL-6在高脂肪餐後有顯著增加(p < 0.05),CRP、TNF-α、IL-1β、IL-8、IL-10皆無顯著變化,本研究在年輕健康受試者顯示單一次耐力運動與單一次阻力運動對於高脂肪餐後所引發的發炎反應無顯著影響。
Postprandial hyperlipidemia state is proposed to increase low-grade systemic inflammation. Long-term exposure in postprandial state may lead to a chronic inflammation, and thus may increase the risk of chronic diseases. Studies have shown moderate intensity exercise may induce an increase in anti-inflammatory cytokines, and decrease the pro-inflammatory cytokines. This study was aimed to investigate the effect of endurance and resistance exercise on high fat meal induced immune responses. Six recreationally active young men (age: 21.7 ± 0.6 years, height: 173.3 ± 2.3 cm, weight: 68.6 ± 3.1 kg) participated in this study. All subjects underwent three 2-day experimental trials in a crossover and randomized design. Subjects were either to rest (control test, C), or to perform endurance exercise at 50%VO2max for 1 h (EE), or to perform a resistance exercise at 80%RM for 2 set of 10-12 repetition (RE) in the afternoon on the day 1. After overnight fasting, subjects were asked to consume oral fat tolerance tests meal and rest for 6 h on the day 2. Each trial was separated at least one week apart, in particularily, after the RE trial, the following trial was separted by 2 weeks. Blood sample were taken via a cannula at fasting and at 30, 60, 120, 240,300 and 360 min during postprandial period. The blood samples analysis included leukocytes counts, lymphocytes counts, neutrophils counts, and plasma C-reactive protein (CRP) and cytokines tumor necrosis factor (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10). The results showed that there were no significant differences in the leukocytes, lymphocytes, neutrophils counts. Plasma IL-6 concentrations were significantly increasedpostprandially (p < 0.05). There were no significant changes in plasma CRP, TNF-α, IL-1β, IL-8, IL-10. The currnt study suggested that the sigle bout of eitherendurance exercise or resistance exercise did not alter high-fat meal-induced inflammatory responses in healthy young subjects.
URI: http://hdl.handle.net/11455/28088
其他識別: U0005-1308201317260300
文章連結: http://www.airitilibrary.com/Publication/alDetailedMesh1?DocID=U0005-1308201317260300
Appears in Collections:運動與健康管理研究所

文件中的檔案:

取得全文請前往華藝線上圖書館



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.