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標題: The elevated serum interleukin-6 correlates with the increased serum butyrate level in patients with nasopharyngeal carcinoma
作者: Chow, K.C.
Chiou, S.H.
Ho, S.P.
Tsai, M.H.
Chen, C.L.
Wang, L.S.
Chi, K.H.
關鍵字: nasopharyngeal carcinoma (NPC)
interleukin-6 (IL-6)
n-sodium butyrate
cancer cell-lines
hepatocyte-stimulating factor
human glioblastoma
iga antibodies
期刊/報告no:: Oncology Reports, Volume 10, Issue 4, Page(s) 813-819.
摘要: We investigated the clinical significance and regulation of serum interleukin-6 (IL-6) in patients with nasopharyngeal carcinoma (NPC). Serum IL-6 levels of 314 NPC patients and 202 healthy individuals were determined. Of the NPC patients, 69.1% (217/314) showed higher IL-6 levels than that of normal average (2.76 +/- 2.06 pg/ml). Elevation of IL-6 correlated with the advanced disease and the adverse prognosis of NPC patients. By employing in situ hybridization technique, IL-6 mRNA was detected in the tumor cells of NPC patients with high serum IL-6 levels. Concurrently, serum levels of butyrate were determined in 147 NPC patients and 52 healthy individuals by gas chromatography. Patients with elevated serum butyrate concentrations (4.2 +/- 2.2 muM) also had significantly higher IL-6 levels (29.14 +/- 5.17 pg/ml). No detectable serum butyrate was measured in the healthy individuals. In order to investigate the direct relationship between butyrate and IL-6, n-sodium butyrate (n-BT) was added to the NPC cells in an in vitro study, and marked increase of IL-6 expression was detected in n-BT-treated cells. Our results suggested that tumor cells could be an important source of elevated serum IL-6 in patients with NPC and that IL-6 level in NPC patients was proportional to the serum butyrate concentration. In vitro, IL-6 expression in NPC cells could be up-regulated by butyrate.
ISSN: 1021-335X
Appears in Collections:獸醫學系所



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