Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/32642
標題: Beneficial effects of yam on carbon tetrachloride-induced hepatic fibrosis in rats
作者: Chan, Y.C.
廖俊旺
Chang, S.C.
Liu, S.Y.
Yang, H.L.
Hseu, Y.C.
Liao, J.W.
張仕杰
關鍵字: lyophilised yam, liver fibrosis
CCI(4), rat
cell-proliferation
lipid-metabolism
dioscorea-alata
chinese-yam
flour diet
liver
antioxidant
silymarin
cirrhosis
mice
期刊/報告no:: Journal of the Science of Food and Agriculture, Volume 90, Issue 1, Page(s) 161-167.
摘要: BACKGROUND: In a previous study, lyophilised yam reduced brain amyloid beta-protein (A beta) accumulation and improved the antioxidative defence system in senescence-accelerated (SAMP8) mice. Therefore, the aim of this study was to investigate the hepatic protection of yam in the carbon tetrachloride-induced hepatic fibrosis of rats. Hepatic fibrosis was induced in rats via intraperitoneal injections Of CCI(4) at a dose of 1 mL kg(-1) body weight (BW) twice weekly for 8 weeks. Three groups of rats were gavaged daily with yams at doses of 0.5, 1 and 2 g kg(-1) BW for 8 weeks, respectively. RESULTS: Yam treatments significantly decreased the ratio of liver/body weight, levels of gamma-glutaminotranspeptidase (GGT), low-density lipoprotein, and triglyceride in serum when compared with those administered CCI(4) alone. Treatment with yams significantly elevated antioxidant activities of glutathione peroxidase (GSH-Px) and superoxidase dismutase (SOD) in livers. Microscopically, yam-treated groups presented with low histoscores Of CCI(4)-induced liver injury and fibrosis. Additionally, yam treatment reduced the area of GGT-positive foci and the index of proliferating cell nuclear antigen (PCNA) in liver. CONCLUSION: Daily administration of yam attenuates CCI(4)-induced hepatic fibrosis in rats in a dose-dependent manner; this attenuation may be related to the antioxidant properties of yams. (c) 2009 Society of Chemical Industry
URI: http://hdl.handle.net/11455/32642
ISSN: 0022-5142
文章連結: http://dx.doi.org/10.1002/jsfa.3801
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