Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/32749
標題: Impairment of Renal Function and Electrolyte Balance in Rabbit Hemorrhagic Disease
作者: Chen, S.Y.
周濟眾
Chou, C.C.
Liu, C.I.
Shien, J.H.
關鍵字: electrolyte balance
rabbit hemorrhagic disease virus
renal
insufficiency
serum
polymerase-chain-reaction
viral disease
animal-model
virus
pathogenesis
expression
infection
failure
rna
期刊/報告no:: Journal of Veterinary Medical Science, Volume 70, Issue 9, Page(s) 951-958.
摘要: Rabbit hemorrhagic disease virus (RHDV) induced viral fulminant hepatitis in adult rabbits. We investigated the damage of renal function and electrolyte balance in experimentally infected rabbit by measuring the related serum parameters to elucidate the pathogenesis of RHDV as an index for medical treatment. Nineteen New Zealand White rabbits, ten females and nine males, were each intramuscularly inoculated with 0.5 m/ 50% rabbit lethal dose (RLD50) rabbit hemorrhagic disease virus. Blood samples were collected at 0 hr post inoculation (HPI) and every 6 hr from 18 HPI repeatedly through 66 HPI. After virus inoculation, serum blood urea nitrogen (BUN), creatinine (CREA) and sodium (Na+) were elevated to a highly significant level (p < 0.0001), whereas serum potassium (K+) was moderately elevated to a significant level (p < 0.05). Hypoglycemia developed highly significantly (p < 0.0001). Serum chloride ion (Cl-) was the only parameter which did not change significantly (p=0.077). No significant sexual difference was observed among these parameters. Renal insufficiency progressed from 36 hr, as indicated by the increases in BUN and CREA; significant changes in electrolytes resulting in the increased osmolality of extracellular fluid that induced flow disturbance which consequently destroy the homeostasis in cells. Therefore, the later impairments in renal function and electrolyte balance might be an important threat for rabbits which might have survived from acute fulminant hepatitis in RHD.
URI: http://hdl.handle.net/11455/32749
ISSN: 0916-7250
文章連結: http://dx.doi.org/10.1292/jvms.70.951
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