Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/32872
標題: Co-exposure of lipopolysaccharide and pseudomonas aeruginosa exotoxin A-induced multiple organ injury in rats
作者: Chiu, C.C.
張登欽
Huang, Y.T.
Chuang, H.L.
Chen, H.H.C.
Chung, T.C.
關鍵字: Cytokines
lipopolysaccharide
multiple organ injury
pseudomonas
aeruginosa exotoxin A
necrosis-factor-alpha
gadolinium chloride
kupffer cells
liver-injury
in-vivo
b-1 hepatotoxicity
mice
apoptosis
endotoxin
posttreatment
期刊/報告no:: Immunopharmacology and Immunotoxicology, Volume 31, Issue 1, Page(s) 75-82.
摘要: Pseudomonas aeruginosa Exotoxin A (PEA) induces hepatotoxicity in experimental animals. Lipopolysaccharide (LPS) interacts synergistically with xenotoxics to induce severe organ injury. We examined the combination of non-injurious doses of LPS and sub-hepatotoxic PEA in the induction of multiple organ injury (MOI). Rats treated with 20 or 40 g/kg LPS plus 10 g/kg PEA developed severe liver, kidney, and lung injury; elevation of TNF-, IFN-, and IL-2; and high mortality. Depletion of Kupffer cells or T-cells by pretreatment with Gadolinium Chloride or FK506, respectively, attenuated MOI. Thus LPS + PEA acted synergistically on Kupffer and T-cells to induce proinflammatory cytokines contributing to MOI.
URI: http://hdl.handle.net/11455/32872
ISSN: 0892-3973
文章連結: http://dx.doi.org/10.1080/08923970802357724
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