請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/32894
標題: FATIGUE REVERSIBLY REDUCED CORTICAL AND HIPPOCAMPAL DENDRITIC SPINES CONCURRENT WITH COMPROMISE OF MOTOR ENDURANCE AND SPATIAL MEMORY
作者: Chen, J.R.
陳建榮
Wang, T.J.
Huang, H.Y.
Chen, L.J.
Huang, Y.S.
Wang, Y.J.
Tseng, G.F.
關鍵字: corticospinal
dendrite
fatigue
hippocampus
plasticity
PSD-95
intracellular dye injection
long-term potentiation
sleep-deprivation
pyramidal neurons
postexercise facilitation
membrane excitability
evoked-potentials
cerebral-cortex
ca1 region
water-maze
期刊/報告no:: Neuroscience, Volume 161, Issue 4, Page(s) 1104-1113.
摘要: Fatigue could be induced following forced exercise, sickness, heat stroke or sleep disturbance and impaired brain-related functions such as concentration, attention and memory. Here we investigated whether fatigue altered the dendrites of central neurons. Central fatigue was induced by housing rats in cage with 1.5-cm deep water for 1-5 days. Three days of sleep deprivation seriously compromised rats' performance in weight-loaded forced swimming and spatial learning tests, and 5 days of treatment worsened it further. Combinations of intracellular dye injection and three-dimensional analysis revealed that dendritic spines on retrograde tracer-identified corticospinal neurons and Cornu Ammonis (CA)1 and CA3 pyramidal neurons were significantly reduced while the shape or length of the dendritic arbors was not altered. Three days of rest restored the spine loss and the degraded spatial learning and weight-loaded forced swimming performances to control levels. In conclusion, although we could not rule out additional non-hypothalamic-pituitary-adrenal stress, the apparent fatigue induced following a few days of sleep deprivation could change brain structurally and functionally and the effects were reversible with a few days of rest. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.
URI: http://hdl.handle.net/11455/32894
ISSN: 0306-4522
文章連結: http://dx.doi.org/10.1016/j.neuroscience.2009.04.022
顯示於類別:獸醫學系所

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