Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/32928
標題: Plural light chains in a single plasma cell of a monoclonal gammopathy undetermined significance case: An ultrastructural study
作者: Saito, N.
黃鴻堅
Konishi, K.
Ohta, S.
Kondo, T.
Kato, M.
Hashino, S.
Takeda, H.
Asaka, M.
Ooi, H.K.
關鍵字: B cell
electron microscopy
light chain
monoclonal gammopathy of
undetermined significance
M-protein
multiple-myeloma
long-term
risk
期刊/報告no:: Human Cell, Volume 20, Issue 1, Page(s) 10-14.
摘要: A 44-year-old man was found to have M-proteins of IgG consisting of kappa- and lambda-chains in serum without lymphadenopathy or splenomegaly. The serum concentrations of IgG, IgA and IgM were within normal limits. Bone marrow examination showed normal cellular marrow containing 6.3% of plasma cells with no abnormal features. No chromosomal abnormality was observed at all. The patient was diagnosed as having monoclonal gammopathy of undetermined significance. The bone marrow plasma cells possessed free kappa- and lambda-chains in Golgi apparatus, rough endoplasmic reticula and cytoplasmic matrices. Plural light chains were simultaneously produced with the same heavy chain in a plasma cell by immunoelectron microscopy. This is the first report in the world of a monoclonal gammopathy of undetermined significance producing plural light chains with the same heavy chain.
URI: http://hdl.handle.net/11455/32928
ISSN: 0914-7470
文章連結: http://dx.doi.org/10.1111/j.1749-0774.2007.00026.x
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