Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/32967
標題: Finding of Neospora caninum in the wild brown rat (Rattus norvegicus)
作者: Huang, C.C.
黃鴻堅
Yang, C.H.
Watanabe, Y.
Liao, Y.K.
Ooi, H.K.
關鍵字: Neospora caninum
rat
cattle farm
natural infection
bovine neospora
nude-mice
cattle
antibodies
diagnosis
infection
isolate
brain
期刊/報告no:: Veterinary Research, Volume 35, Issue 3, Page(s) 283-290.
摘要: Nine rats (16.4%) out of 55 (Rattus norvegicus) from cattle farms were seropositive to Neospora caninum. Two of the seropositive rats were also PCR positive but all were negative by immunohistochemistry and PAS staining. The brains of all the captured rats were homogenized and initially inoculated intraperitoneally into nude mice or into SPF ICR mice, which had been immunosuppressed with prednisolone. One mouse that was inoculated with brain material from a seropositive rat became infected with N. caninum, as demonstrated by the presence of a tissue cyst in the brain and confirmed by immunohistochemistry and PCR. This is the first finding of N. caninum in naturally infected farm rats. The findings show that natural N. caninum infection occurs in wild brown rats and thus rats may serve as a reservoir for the protozoan on the cattle farm.
URI: http://hdl.handle.net/11455/32967
ISSN: 0928-4249
文章連結: http://dx.doi.org/10.1051/vetres:2004010
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