Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/32978
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dc.contributor.authorPeng, H.Y.en_US
dc.contributor.author董光中zh_TW
dc.contributor.authorChang, H.M.en_US
dc.contributor.authorLee, S.D.en_US
dc.contributor.authorHuang, P.C.en_US
dc.contributor.authorChen, G.D.en_US
dc.contributor.authorLai, C.H.en_US
dc.contributor.authorLai, C.Y.en_US
dc.contributor.authorChiu, C.H.en_US
dc.contributor.authorTung, K.C.en_US
dc.contributor.authorLin, T.B.en_US
dc.date2008zh_TW
dc.date.accessioned2014-06-06T07:44:33Z-
dc.date.available2014-06-06T07:44:33Z-
dc.identifier.issn1931-857Xzh_TW
dc.identifier.urihttp://hdl.handle.net/11455/32978-
dc.description.abstractPeng H-Y, Chang H-M, Lee S-D, Huang P-C, Chen G-D, Lai C-H, Lai C-Y, Chiu C-H, Tung K-C, Lin T-B. TRPV(1) mediates the uterine capsaicin-induced NMDA NR2B-dependent cross-organ reflex sensitization in anesthetized rats. Am J Physiol Renal Physiol 295: F1324-F1335, 2008. First published July 16, 2008; doi:10.1152/ajprenal.00126.2008.-Spinal cord-mediated cross-organ sensitization between the uterus and the lower urinary tract may underlie the high concurrence of obstetrical/gynecological inflammation and chronic pelvic pain syndrome characterized by urogenital pain. However, the neural pathway and the neurotransmitters involved are still unknown. We tested the hypothesis that the excitation of capsaicin-sensitive primary afferent fibers arising from the uterus through the stimulation of transient receptor potential vanilloid 1 (TRPV(1)) induces cross-organ sensitization on the pelvic-urethra reflex activity. Capsaicin (1-1,000 mu M, 0.05 ml) was instilled into the uterus to induce cross-organ reflex sensitization. Activation of capsaicin-sensitive primary afferent fibers by capsaicin instillation into the uterine horn sensitized the pelvic-urethra reflex activity that was reversed by an intrauterine pretreatment with capsaizepine, a TRPV(1)-selective antagonist. Intrathecal injection of AP5, a glutamatergic N-methyl-D-aspartate (NMDA) antagonist, and Co-101244, an NMDA NR2B-selective antagonist, both abolished the cross-organ reflex sensitization caused by capsaicin instillation. These results demonstrated that TRPV(1) plays a crucial role in contributing to the capsaicin-sensitive primary afferent fibers mediating the glutamatergic NMDA-dependent cross-organ sensitization between the uterus and the lower urinary tract when there is a tissue injury.en_US
dc.language.isoen_USzh_TW
dc.relationAmerican Journal of Physiology-Renal Physiologyen_US
dc.relation.ispartofseriesAmerican Journal of Physiology-Renal Physiology, Volume 295, Issue 5, Page(s) F1324-F1335.en_US
dc.relation.urihttp://dx.doi.org/10.1152/ajprenal.00126.2008en_US
dc.subjectspinal corden_US
dc.subjectC-fiberen_US
dc.subjectpainen_US
dc.subjectdesensitizationen_US
dc.subjectpostinjury pain hypersensitivityen_US
dc.subjectirritable-bowel-syndromeen_US
dc.subjectloweren_US
dc.subjecturinary-tracten_US
dc.subjectvanilloid receptoren_US
dc.subjectdorsal-hornen_US
dc.subjectglutamate receptorsen_US
dc.subjectdescending facilitationen_US
dc.subjectintradermal injectionen_US
dc.subjectsynaptic transmissionen_US
dc.subjectinterstitial cystitisen_US
dc.titleTRPV(1) mediates the uterine capsaicin-induced NMDA NR2B-dependent cross-organ reflex sensitization in anesthetized ratsen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1152/ajprenal.00126.2008zh_TW
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