Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/32979
標題: Activated matrix metalloproteinase and disrupted myocardial collagen matrix in increased sympathetic activity following stimulation of dorsal medulla in the vagotomized feline model
作者: Cheng, C.C.
董光中
Tung, K.C.
Fu, Y.C.
Gong, C.L.
Chen, Y.T.
Lin, N.N.
Lin, J.A.
Chin, Y.T.
關鍵字: extracellular collagen matrix
matrix metalloproteinases
sympathetic
nervous activity
heart failure
animal model
congestive-heart-failure
subarachnoid hemorrhage
animal-model
hypertrophic cardiomyopathy
inhibition
plasma
cats
rat
microdialysis
stroke
期刊/報告no:: Chinese Journal of Physiology, Volume 51, Issue 1, Page(s) 7-12.
摘要: Sympathetic hyperactivation in many kinds of neurocardiogenic injury can result in obvious heart failure. We generated a vagotomized feline model in which sympathetic hyperactivation was induced by electrical stimulation of dorsal medulla (ESDM) of brain stem to investigate the relationship between disruption of extracellular collagen matrix (ECM) and activation of matrix metalloproteinases (MMPs) in myocardium in the sympathetic hyperactivity. Mean blood pressure, heart rate and plasma norepinephrine were all significantly increased from baseline to a peak at 5 min after ESDM. Echocardiographic study showed significant left ventricular dilatation and hypokinesia (ejection fraction: from 87.7 +/- 6.3% to 39.4 +/- 7.8%) from baseline to 180 mm after ESDM. Histopathological finding revealed significant overstretching or spring-like disappearance and disruption of ECM. MMP-2 expression was significantly increased in left ventricular myocardium as compared to sham. These results suggest that ESDM-induced sympathetic hyperactivity causes the expression of MMP-2 that disrupts myocardial ECM, contributing to the development of cardiac dysfunction.
URI: http://hdl.handle.net/11455/32979
ISSN: 0304-4920
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