Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/32981
標題: The impact of different closure materials on pharyngeal wound healing: an experimental animal study
作者: Liu, S.A.
董光中
Tung, K.C.
Cheng, C.C.
Chiu, Y.T.
關鍵字: pharyngo-cutaneous fistula
suture
animal model
polypropylene
fibrin
glue
pharyngocutaneous fistula
surgery
cancer
5-fluorouracil
complications
anastomoses
immediate
larynx
head
glue
期刊/報告no:: European Archives of Oto-Rhino-Laryngology, Volume 265, Issue 2, Page(s) 227-231.
摘要: The formation of pharyngo-cutaneous fistula (PCF) is controversial and various predisposing factors have been proposed. This study aimed to compare different suture materials in the closure of pharyngeal wounds in experimental animals. Fifty-two Sprague-Dawley rats were divided into three groups. Artificial pharyngotomy was performed and was then repaired with Vicryl, polypropylene, and Vicryl plus fibrin glue, respectively. Outcome measurements included gross wound inspection and histological examination. There was a significant difference in the rates of PCF formation between group I and group II (Fisher's exact test, p = 0.046). In addition, minimal inflammatory response was found in the polypropylene group when compared to the other groups. The fibrin glue-treated group had the highest fibroblast activity and collagen deposition. Polypropylene produced minimal tissue reaction, which facilitated the healing process. Therefore, proper selection of suture material can probably reduce the rate of PCF but should not be substituted for proper aseptic and meticulous surgical techniques.
URI: http://hdl.handle.net/11455/32981
ISSN: 0937-4477
文章連結: http://dx.doi.org/10.1007/s00405-007-0431-9
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