Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/33077
標題: Beneficial effect of Toona sinensis Roemor on improving cognitive performance and brain degeneration in senescence-accelerated mice
作者: Liao, J.W.
廖俊旺
Hsu, C.K.
Wang, M.F.
Hsu, W.M.
Chan, Y.C.
關鍵字: Toona sinensis Roemor
cognitive ability
amyloid beta-protein
deposition
antioxidative system
beta-amyloid protein
transgenic mouse model
alzheimers-disease
oxidative stress
superoxide-dismutase
antioxidant capacity
in-vivo
damage
melatonin
rats
期刊/報告no:: British Journal of Nutrition, Volume 96, Issue 2, Page(s) 400-407.
摘要: The purpose of the present study was to examine the effects of Toona sinensis Roemor extracts on antioxidative activities, brain morphological changes and cognitive ability. In an in vitro study, the antioxidant capacities of water extracts from Toona sinensis Roemor leaf (TSL), root (TSR) and bark (TSB) were evaluated by an alpha,alpha-diphenyl-beta-pricryl-hydrazyl radical-scavenging test. The results showed that the scavenging activities of all Toona sinensis Roemor extracts were over 80 % at a concentration of 0 center dot 625 mg/ml. In an in vivo study, 3-month-old male senescence-accelerated-prone 8 mice were used as the tested subjects and fed four different diets: casein diet or casein diet supplemented with 1 % TSL, TSR or TSB extract for 12 weeks. The results showed that the mice supplemented with Toona sinensis Roemor extracts demonstrated significantly less amyloid beta-protein deposition and lower levels of thiobarbituric acid-reactive substances than the control group. All Toona sinensis Roemor diet groups also showed better active shuttle avoidance responses, and higher superoxide dismutase, catalase and glutathione peroxidase activities, than the control group. It can thus be concluded that supplementation with either TSL, TSR or TSB extract could not only reduce the incidence of ss-amyloid plaques, but also improve learning and memory ability in senescence-accelerated-prone 8 mice. This might be due to the beneficial effects of Toona sinensis Roemor extracts on promoting the antioxidative defence system.
URI: http://hdl.handle.net/11455/33077
ISSN: 0007-1145
文章連結: http://dx.doi.org/10.1079/bjn20061823
Appears in Collections:獸醫病理生物學所

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