Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/33112
標題: Homocysteine and other biochemical parameters in Type 2 diabetes mellitus with different diabetic duration or diabetic retinopathy
作者: Huang, E.J.
陳德勛
Kuo, W.W.
Chen, Y.J.
Chen, T.H.
Chang, M.H.
Lu, M.C.
Tzang, B.S.
Hsu, H.H.
Huang, C.Y.
Lee, S.D.
關鍵字: NIDDM
hyperhomocysteinemia
lactate dehydrogenase
retinopathy
serum uric-acid
risk
disease
complications
association
heart
期刊/報告no:: Clinica Chimica Acta, Volume 366, Issue 1-2, Page(s) 293-298.
摘要: Background: Cardiovascular risk-related markers in type 2 diabetes mellitus (DM) have not been well understood. Methods: Serum and urine samples for biochemical and immunologic analysis were collected from 204 normal subjects and 257 type 2 DM patients, the latter of which were further classified by different diabetic duration with or without retinopathy. Results: Glycosylated hemoglobin Ale, triglyceride, lipase, free fatty acid, albumin creatinine ratio (ACR), lactate dehydrogenase (LDH) and homocysteine were significantly increased in DM patients, whereas high density lipoprotein cholesterol and bilirubin were significantly decreased in DM patients, compared with normal subjects. Lipid profiles, ACR, bilirubin, uric acid, creatine kinase, and hsCPP were not changed in DM patients with different diabetic duration or diabetic retinopathy. Lactate dehydrogenase in DM patients with duration > 20 years and homocysteine in patients with duration > 10 years was significantly higher than those with duration > 5 years. Homocysteine was significantly increased in DM patients with retinopathy, compared with DM patients without retinopathy. Conclusion: The increased triglyceride, lipase, free fatty acid, albumin creatinine ratio, lactate dehydrogenase and homocysteine as well as decreased high density lipoprotein cholesterol and anti-oxidative bilirubin in DM patients should be cautious and considered as risks for increasing DM complication. Homocysteine might be associated with longer diabetic duration and microvascular complication of retinopathy in diabetes. (c) 2005 Elsevier B.V. All rights reserved.
URI: http://hdl.handle.net/11455/33112
ISSN: 0009-8981
文章連結: http://dx.doi.org/10.1016/j.cca.2005.10.025
Appears in Collections:獸醫病理生物學所

文件中的檔案:

取得全文請前往華藝線上圖書館



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.