Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/33121
標題: Different bacteria species lipopolysaccharide co-exposure with Pseudomonas exotoxin A on multiple organ injury induction
作者: Chuang, H.L.
陳德勛
Chiu, C.C.
Chen, T.H.
Chen, H.H.C.
Chu, Y.Y.
Huang, Y.T.
關鍵字: necrosis-factor-alpha
salmonella-typhimurium endotoxemia
a-induced
hepatotoxicity
lethal escherichia-coli
aeruginosa exotoxin
liver-injury
mice
rats
cells
modulation
期刊/報告no:: Immunopharmacology and Immunotoxicology, Volume 31, Issue 4, Page(s) 616-624.
摘要: The present study investigated the effect of different bacterial species lipopolysaccharide plus Pseudomonas exotoxin A (LPS/PEA) on the induction of multiple organ injury (MOI). Rats were injected with various LPS from Salmonella (SAE, SAT), E. coli (EB4, EB5), or P. aeruginosa (PAL) and PEA showed a greater mortality in the SAE/PEA and SAT/PEA groups. Histological alterations, serum enzymes, and cytokines changes were severer in the SAE/PEA group than the EB4/PEA or PAL/PEA group. EB4/PEA and PAL/PEA failed to induce MOI, even at the LPS doses increased up to 2-4- and 4-8-fold, respectively. Rats co-treated with Salmonella lipid A/PEA developed severer MOI than the E. coli lipid A/PEA. The results indicated the critical roles of MOI induction, which were related to LPS derived from appropriate bacterial species.</.
URI: http://hdl.handle.net/11455/33121
ISSN: 0892-3973
文章連結: http://dx.doi.org/10.3109/08923970902926402
Appears in Collections:獸醫病理生物學所

文件中的檔案:

取得全文請前往華藝線上圖書館



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.