Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/33150
DC FieldValueLanguage
dc.contributor.authorLiao, J.W.en_US
dc.contributor.author廖俊旺zh_TW
dc.contributor.authorChung, Y.C.en_US
dc.contributor.authorYeh, J.Y.en_US
dc.contributor.authorLin, Y.C.en_US
dc.contributor.authorLin, Y.G.en_US
dc.contributor.authorWu, S.M.en_US
dc.contributor.authorChan, Y.C.en_US
dc.date2007zh_TW
dc.date.accessioned2014-06-06T07:45:01Z-
dc.date.available2014-06-06T07:45:01Z-
dc.identifier.issn0278-6915zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/33150-
dc.description.abstractThe purposes of this study were to evaluate the safety of water extracts of Toona sinensis Roemor leaf (TSL-1). The mutagenic properties of TSL-1 was investigated using the Ames test, and no mutagenicity was found toward all tester strains (Salmonella typhimurium TA98, TA100, TA102 and TA1535). In the acute oral toxicity study, a single limit dose of 5000 mg TSL-1/kg bw was given to male and female ICR mice, then observed for a 14-day period. In the subacute study, TSL-1 was administered as oral daily dose of 1000 mg/kg bw/day for 28 days. The results showed no acute lethal effect at a maximal tested dose of 5000 mg/kg bw TSL-1 in male and female mice. The subacute toxicity showed the oral administration of 1000 mg/kg bw for consecutive 28 days was safe in male mice. TSL-1 treated female mice showed decreases of food intake and kidney relative weight in acute oral toxicity test, and decreases of body weight gain, food intake and lung relative weight in subacute toxicity trial. However, no remarked toxic effects were found in the biochemical and histopathological parameters of TSL-1 treated female mice. These effects whether related to the major components or other ingredients in TSL-1 need to elucidate in the further studies. (c) 2007 Elsevier Ltd. All rights reserved.en_US
dc.language.isoen_USzh_TW
dc.relationFood and Chemical Toxicologyen_US
dc.relation.ispartofseriesFood and Chemical Toxicology, Volume 45, Issue 8, Page(s) 1393-1399.en_US
dc.relation.urihttp://dx.doi.org/10.1016/j.fct.2007.01.020en_US
dc.subjectToona sinensis roemoren_US
dc.subjectmutagenicityen_US
dc.subjectacute oral toxicityen_US
dc.subjectsubacute oralen_US
dc.subjecttoxicityen_US
dc.subjectadverse-effect-levelen_US
dc.subjectgallic aciden_US
dc.subjecthydrogen-peroxideen_US
dc.subjectcytotoxicityen_US
dc.subjectquercetinen_US
dc.subjectapoptosisen_US
dc.subjectgallateen_US
dc.subjectcommonen_US
dc.subjectcellsen_US
dc.subjectrutinen_US
dc.titleSafety evaluation of water extracts of Toona sinensis Roemor leafen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1016/j.fct.2007.01.020zh_TW
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