請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/33155
標題: Effect of the administration of Lactobacillus paracasei subsp paracasei NTU 101 on Peyer's patch-mediated mucosal immunity
作者: Tsai, Y.T.
廖俊旺
Cheng, P.C.
Liao, J.W.
Pan, T.M.
關鍵字: Peyer's patches
Mucosal immunity
Immunomodulation
Probiotics
human dendritic cells
naive b-cells
t-cells
lymph-nodes
cd40 ligand
gut
spleen
milk
persistence
expression
期刊/報告no:: International Immunopharmacology, Volume 10, Issue 7, Page(s) 791-798.
摘要: The role of lactic acid bacteria in gut mucosal immunity was investigated by comparing the enhanced effects in the Peyer's patches and spleen of BALB/c mice fed daily with Lactobacillus paracasei subsp. paracasei NTU 101 for 3 to 9 weeks. After feeding with Lactobacillus, the percentage of CD4(+) T cells in both Peyer's patches and the spleen was significantly increased: however, expression of CD 154 molecules, which play a pivotal role in cell-to-cell communication, on CD4(+) T cells and the percentage of B220(+) B cells increased only in Peyer's patches. Compared with systemic serum IgA, Peyer's patch-derived immunomodulation induced higher levels of intestinal IgA(+)-producing cells in the lamina propria. Our data also showed that feeding with Lactobacillus induced stronger CD4(+) T cell-dendritic cell interaction, enhanced CD4(+) T cell and B cell proliferation, and increased IL-1 beta, 1L-10, IL-12, IFN-gamma, and TNF-alpha mRNA expression in Peyer's patches, but not in the spleen. Here, we demonstrate that following Lactobacillus treatment, Peyer's patches exhibited a more distinct capacity to induce CD4(+) T cell-dendritic cell interactions, lymphocyte proliferation, and cytokine secretion than the spleen, and thereby promoted greater intestinal IgA production that could enhance immunosurveillance to prevent intestinal infections or other intestinal pathologies. (C) 2010 Elsevier B.V. All rights reserved.
URI: http://hdl.handle.net/11455/33155
ISSN: 1567-5769
文章連結: http://dx.doi.org/10.1016/j.intimp.2010.04.012
顯示於類別:獸醫病理生物學所

文件中的檔案:
沒有與此文件相關的檔案。


在 DSpace 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。