Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/33166
標題: Mutagenic Safety and Fatty Liver Improvement of Nanonized Black Soybeans in Senescence-Accelerated Prone-8 Mice
作者: Liao, J.W.
廖俊旺
Hong, L.Z.
Wang, M.F.
Tsai, S.C.
Lin, Y.J.
Chan, Y.C.
關鍵字: fatty liver
nanonized black soybean
safety
senescence-accelerated
mice
density-lipoprotein oxidation
healthy adult mice
nano-se
in-vitro
glutathione-peroxidase
superoxide-dismutase
subchronic toxicity
rats
antioxidant
genistein
期刊/報告no:: Journal of Food Science, Volume 75, Issue 5, Page(s) T82-T90.
摘要: Nanotechnology, as a new enabling technology, has the potential to revolutionize food systems. However, much attention has been focused on nanoparticle foods due to their potential physiological properties. This study was aimed to evaluate the mutagenic safety and fatty liver improvement of black soybean in senescence-accelerated mice (SAMP8). The mutagenic activity of black soybeans was investigated using the Ames test (Salmonella Typhimurium TA98, 100, 102, and 1535). Furthermore, senescence-accelerated prone-8 mice (SAMP8) have been reported to display spontaneous fatty liver. Male SAMP8 mice were divided into control and supplemented with 10% micronized or nanonized black soybeans diet and fed for 12 wk. The results revealed that the Ames test of micronized and nanonized black soybeans exhibited no mutagenicity. Administration of black soybeans to mice showed no effects on food intake and body and organ weights. The nanonized black soybean group had a lower degree of spontaneous fatty liver, alanine aminotransferase, and thiobarbituric acid-reactive substance concentrations, and had enhanced superoxide dismutase, catalase, and glutathione peroxidase activities of livers when compared with the SAMP8 control and micronized black soybean groups. The mice fed with black soybeans had significantly lower triglyceride concentrations than the SAMP8 control group. The results of this study suggest that nanonized black soybeans have no side effects and, moreover, may minimize liver lesions in SAMP8 mice.
URI: http://hdl.handle.net/11455/33166
ISSN: 0022-1147
文章連結: http://dx.doi.org/10.1111/j.1750-3841.2010.01638.x
Appears in Collections:獸醫病理生物學所

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