Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/33833
標題: Alkyne-mediated domino hydroformylation/double cyclization: mechanistic insight and synthesis of (+/-)-tashiromine
作者: Chiou, Wen-Hua
Lin, Yi-Huei
Chen, Guei-Tang
Gao, Yu-Kai
Tseng, Yu-Che
Kao, Chien-Lun
Tsai, Jui-Chi
關鍵字: stereoselective hydroformylation
indolizidine alkaloids
aza-annulation
(+)-tashiromine
tashiromine
route
(+/-)-5-epitashiromine
strategies
reduction
chemistry
摘要: A novel domino reaction, alkyne-mediated domino hydroformylation/double cyclization, has been developed for rapid preparation of indolizidine type alkaloids. DFT calculations were applied for rationales of reactivity and selectivity. A concise synthesis of tashiromine as the application of the methodology is also reported.
URI: http://hdl.handle.net/11455/33833
ISSN: 1359-7345
Appears in Collections:化學系所

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