Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/34318
標題: Dynamic Probing of Nanoparticle Stability In Vivo: A Liposomal Model Assessed Using In Situ Microdialysis and Optical Imaging
作者: Jeng, C.C.
鄭建宗
Cheng, S.H.
Ho, J.A.A.
Huang, S.H.Y.
Chang, J.C.
Tsai, P.J.
Yang, C.S.
Lo, L.W.
關鍵字: surface-charge
clearance
permeability
mice
期刊/報告no:: Journal of Nanomaterials.
摘要: Nanoparticle-mediated drug delivery and controlled release has been a vigorous research area in contemporary nanomedicine. The in vivo stability of nanoparticle delivered on site is a prerequisite for the design of drug-controlled release by any means. In this study, the first methodology comprised of microdialysis and optical imaging to assess the liposome stability in vivo is reported. Macroscopically, we demonstrated the DPPG liposomes with negative surface charge fast accumulated in the rat liver upon their i.v. administration using optical imaging. Microscopically, the concurrent analysis of fluorescent molecules leaching from the liposomes, in situ sampled using microdialysis probe, provides the dynamic information of stability of DPPG liposomes locus in quo. The current combination of in situ microdialysis and optical imaging possesses a great potential for use as a platform technology to evaluate the nanoparticle stability and the bioavailability of drug payload released on targeted site in vivo.
URI: http://hdl.handle.net/11455/34318
ISSN: 1687-4110
文章連結: http://dx.doi.org/10.1155/2011/932719
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