Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/34468
標題: Aponeocarzinostatin - A superior drug carrier exhibiting unusually high endurance against denaturants
作者: Sudhahar, C.G.
金德航
Chin, D.H.
關鍵字: aponeocarzinostatin
antitumor antibiotic chromoprotein
enediyne
denaturants
guanidine-hydrochloride denaturation
beta-lactoglobulin
apo-neocarzinostatin
structural stability
solvent denaturation
antitumor protein
alpha-lactalbumin
crystal-structure
human
glycodelin
ph-dependence
期刊/報告no:: Bioorganic & Medicinal Chemistry, Volume 14, Issue 10, Page(s) 3543-3552.
摘要: The enediyne antitumor antibiotic chromoproteins are very potent in causing DNA damages. During the drug delivery time course, the stability of the carrier protein becomes all important concern. To simulate conceivably offensive environment in biological contexts, such as cell membrane, we studied structural endurance of aponeocarzinostatin against several denaturants by circular dichroism and nuclear magnetic resonance spectroscopy. For comparison, we also examined proteins known to be stable and similar in size to aponeocarzinostatin The results highlight the unusual structural stability of aponeocarzinostatin against chemical denaturants, Suggesting the potential of aponeocarzinostatin as an inherently superior carrier in drug delivery systems. (c) 2006 Elsevier Ltd. All rights reserved.
URI: http://hdl.handle.net/11455/34468
ISSN: 0968-0896
文章連結: http://dx.doi.org/10.1016/j.bmc.2006.01.012
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