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標題: Efficiency of interleukin-4 expression in patients with tuberculosis and nontubercular pneumonia
作者: Wu, H.P.
Wu, C.L.
Yu, C.C.
Liu, Y.C.
Chuang, D.Y.
關鍵字: interleukin-4
interleukin-4 delta 2
alternative splice variant
human lung fibroblasts
cytokine responses
human il-4
期刊/報告no:: Human Immunology, Volume 68, Issue 10, Page(s) 832-838.
摘要: In the early stage of Mycobacterium tuberculosis infection, macrophages, in cooperation with interferon-gamma, a Th1 effector, are the first tine of defense. Interteukin (IL)-4, a Th2 effector, is known to downregulate interferon-gamma. It is believed that the expression levels of IL-4 and its splicing variant-IL-4 delta 2 might be associated with Mycobacterium tuberculosis infection and chest radiographic patterns. The IL-4 and IL-4 delta 2 expressions in stimulated peripheral blood mononuclear cells of 76 tuberculosis patients, 48 pneumonic patients. and 36 healthy control subjects were evaluated by nested reverse transcriptase-polymerase chain reaction, and the expression of glyceraidehydes-3-phosphate dehydrogenase was used as an internal reference. The results showed that IL-4 mRNA expression was significantly decreased in patients with tuberculosis and nontubercular pneumonia compared with that in controls. The IL-4 delta 2 mRNA expression was positively correlated with IL-4 mRNA expression in all cases. The ratio of IL-4 delta 2 to IL-4 mRNA expression in tubercular patients with a cavity on chest radiography was significantly lower than that in patients without a chest cavity. In conclusion, the ratio of IL-4 delta 2 to IL-4 mRNA expression may play a key role in disease severity for patients with pulmonary tuberculosis. From our observations, the IL-4 mRNA expression efficiency was attenuated in patients with pulmonary infection, either tuberculosis or pneumonia. (c) 2007 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
ISSN: 0198-8859
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