Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/34620
標題: Comparison of interferon-gamma response between tuberculosis and non-tubercular pneumonia
作者: Wu, H.P.
莊敦堯
Hua, C.C.
Liu, Y.C.
Chuang, D.Y.
關鍵字: interferon-gamma
tuberculosis
pneumoconiosis
diabetes mellitus
cavity
mycobacterium-tuberculosis
pulmonary tuberculosis
ifn-gamma
assay
activation
infection
diagnosis
profiles
children
antigens
期刊/報告no:: Inflammation Research, Volume 56, Issue 1, Page(s) 11-16.
摘要: Objective and design: Macrophages aided by interferon-gamma (IFN-gamma) are vital to controlling Mycobacterium tuberculosis (M. tuberculosis) infection. Although numerous studies have compared IFN-gamma response between tubercular patients and healthy controls, no studies have investigated IFN-gamma response in patients with pulmonary tuberculosis and non-tubercular pneumonia. The aim of this work was to examine the difference in IFN-gamma response between patients with tuberculosis and non-tubercular pneumonia. Methods: IFN-gamma production was detected based on the difference in supernatants between non-stimulated and stimulated peripheral blood mononuclear cells by phytohernagglutinin in 83 tubercular patients and 47 patients with pneumonia. Presence of a cavity on chest radiography and co-morbidities of pneurnoconiosis, bronchiectasis, liver cirrhosis, renal failure on hemodialysis, diabetes mellitus (DM) and lung cancer were recorded for analysis. Results: Interferon-gamma response, DM and a cavity on chest radiography were independent factors for predicting active pulmonary tuberculosis. Interferon-gamma response was decreased in patients with pulmonary tuberculosis compared with that in patients with non-tubercular pneumonia. Notably, M. tuberculosis infection was the principal factor correlated with IFN-gamma response. Conclusion: The IFN-gamma response was principally affected by M. tuberculosis infection and not by other co-morbidities. Further study is required to identify the mechanism of decreased IFN-gamma production.
URI: http://hdl.handle.net/11455/34620
ISSN: 1023-3830
文章連結: http://dx.doi.org/10.1007/s00011-007-6038-1
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