Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/34621
標題: Serial cytokine levels in patients with severe sepsis
作者: Wu, H.P.
莊敦堯
Chen, C.K.
Chung, K.
Tseng, J.C.
Hua, C.C.
Liu, Y.C.
Chuang, D.Y.
Yang, C.H.
關鍵字: Sepsis
Cytokine
Human
Interleukin-6
Interleukin-10
Transforming
growth factor-beta1
regulatory t-cells
hla-dr expression
septic shock
immune-responses
disease severity
therapy
association
interleukin-10
inflammation
interferon
期刊/報告no:: Inflammation Research, Volume 58, Issue 7, Page(s) 385-393.
摘要: The serial or dynamic changes of cytokine levels in severely septic patients, between shock and no shock, survivors and non-survivors are still unclear. Seventy-six patients with severe sepsis were enrolled to our study. Plasma levels of interferon-gamma, interleukin (IL)-6, IL-10, IL-12 and transforming growth factor-beta 1 from day 1 to day 7 were determined. IL-6 level in non-survivors was higher than that in survivors on day 1. IL-10 level in non-survivors was higher than that in survivors on day 1, 2, and 3. IL-6 level in shock patients was higher than that in non-shock patients on day 1, 2, 6 and 7. IL-10 level in shock patients was higher than that in non-shock patients from day 1 to day 7. Plasma time-course curves of IL-6 and IL-10 were different between survivors and non-survivors. Plasma time-course curve of IL-6 was different between patients with shock and without shock. Regression analysis found that IL-6 was correlated with IL-10 and shock. IL-10 was correlated with IL-6 and mortality. IL-6 and IL-10 were the key cytokines in the pathogenesis of severe sepsis. IL-6 was comparatively more associated with septic shock and IL-10 was comparatively more associated with mortality.
URI: http://hdl.handle.net/11455/34621
ISSN: 1023-3830
文章連結: http://dx.doi.org/10.1007/s00011-009-0003-0
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