Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/34621
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dc.contributor.authorWu, H.P.en_US
dc.contributor.author莊敦堯zh_TW
dc.contributor.authorChen, C.K.en_US
dc.contributor.authorChung, K.en_US
dc.contributor.authorTseng, J.C.en_US
dc.contributor.authorHua, C.C.en_US
dc.contributor.authorLiu, Y.C.en_US
dc.contributor.authorChuang, D.Y.en_US
dc.contributor.authorYang, C.H.en_US
dc.date2009zh_TW
dc.date.accessioned2014-06-06T07:48:02Z-
dc.date.available2014-06-06T07:48:02Z-
dc.identifier.issn1023-3830zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/34621-
dc.description.abstractThe serial or dynamic changes of cytokine levels in severely septic patients, between shock and no shock, survivors and non-survivors are still unclear. Seventy-six patients with severe sepsis were enrolled to our study. Plasma levels of interferon-gamma, interleukin (IL)-6, IL-10, IL-12 and transforming growth factor-beta 1 from day 1 to day 7 were determined. IL-6 level in non-survivors was higher than that in survivors on day 1. IL-10 level in non-survivors was higher than that in survivors on day 1, 2, and 3. IL-6 level in shock patients was higher than that in non-shock patients on day 1, 2, 6 and 7. IL-10 level in shock patients was higher than that in non-shock patients from day 1 to day 7. Plasma time-course curves of IL-6 and IL-10 were different between survivors and non-survivors. Plasma time-course curve of IL-6 was different between patients with shock and without shock. Regression analysis found that IL-6 was correlated with IL-10 and shock. IL-10 was correlated with IL-6 and mortality. IL-6 and IL-10 were the key cytokines in the pathogenesis of severe sepsis. IL-6 was comparatively more associated with septic shock and IL-10 was comparatively more associated with mortality.en_US
dc.language.isoen_USzh_TW
dc.relationInflammation Researchen_US
dc.relation.ispartofseriesInflammation Research, Volume 58, Issue 7, Page(s) 385-393.en_US
dc.relation.urihttp://dx.doi.org/10.1007/s00011-009-0003-0en_US
dc.subjectSepsisen_US
dc.subjectCytokineen_US
dc.subjectHumanen_US
dc.subjectInterleukin-6en_US
dc.subjectInterleukin-10en_US
dc.subjectTransformingen_US
dc.subjectgrowth factor-beta1en_US
dc.subjectregulatory t-cellsen_US
dc.subjecthla-dr expressionen_US
dc.subjectseptic shocken_US
dc.subjectimmune-responsesen_US
dc.subjectdisease severityen_US
dc.subjecttherapyen_US
dc.subjectassociationen_US
dc.subjectinterleukin-10en_US
dc.subjectinflammationen_US
dc.subjectinterferonen_US
dc.titleSerial cytokine levels in patients with severe sepsisen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1007/s00011-009-0003-0zh_TW
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