Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/34625
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dc.contributor.authorWu, H.P.en_US
dc.contributor.author莊敦堯zh_TW
dc.contributor.authorWu, C.L.en_US
dc.contributor.authorChen, C.K.en_US
dc.contributor.authorChung, K.en_US
dc.contributor.authorTseng, J.C.en_US
dc.contributor.authorLiu, Y.C.en_US
dc.contributor.authorChuang, D.Y.en_US
dc.date2008zh_TW
dc.date.accessioned2014-06-06T07:48:03Z-
dc.date.available2014-06-06T07:48:03Z-
dc.identifier.issn0883-9441zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/34625-
dc.description.abstractPurpose: Sepsis is a complicated syndrome in which proinflammatory and anti-inflammatory cytokines are expressed simultaneously. However, it remains unclear for the expression of interleukin (IL)-4 and IL-4 delta 2 in patients with severe sepsis. Materials and Methods: By nested reverse transcriptase-polymerase chain reaction and the expression of glyceraldehydes-3-phosphate dehydrogenase as the internal reference, the expression levels of IL-4 and IL-4 delta 2 were determined in peripheral blood mononuclear cells (PBMCs) of 76 patients with severe sepsis and were immediately admitted to an intensive care unit. Plasma IL-4 level was measured by enzyme-linked immunosorbent assay. Clinical characteristics were monitored and recorded prospectively. Results: The IL-4 messenger RNA (mRNA) expression in PBMCs of patients who had survived was significantly higher than that of those who had died. The IL-4 delta 2/IL-4 ratio in PBMCs of patients who had survived was significantly lower than that of those who had died. The IL-4 delta 2 expression did not differ between survivors and nonsurvivors. After regression analysis, the IL-4 delta 2/IL-4 ratio still was all independent factor for death in patients with severe sepsis. The expression of IL-4 delta 2 mRNA was positively correlated with that of IL-4 mRNA in patients with severe sepsis. The plasma IL-4 levels ill septic patients oil admission day did not differ between survivors and nonsurvivors. Conclusions: The IL-4 mRNA expression might be associated with survival in patients with severe sepsis. The IL-4 delta 2/IL-4 ratio might be served as the net immunity of IL-4 activity. (c) 2008 Elsevier Inc. All rights reserved.en_US
dc.language.isoen_USzh_TW
dc.relationJournal of Critical Careen_US
dc.relation.ispartofseriesJournal of Critical Care, Volume 23, Issue 4, Page(s) 519-524.en_US
dc.relation.urihttp://dx.doi.org/10.1016/j.jcrc.2007.11.008en_US
dc.subjectInterleukin-4en_US
dc.subjectInterleukin-4 delta 2en_US
dc.subjectSepsisen_US
dc.subjectCytokinesen_US
dc.subjectHumanen_US
dc.subjectalternative splice varianten_US
dc.subjectcell-proliferationen_US
dc.subjecthuman il-4en_US
dc.subjectil-4-delta-2en_US
dc.subjecttuberculosisen_US
dc.subjectgammaen_US
dc.titleThe interleukin-4 expression in patients with severe sepsisen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1016/j.jcrc.2007.11.008zh_TW
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