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標題: Plasma Transforming Growth Factor-beta 1 Level in Patients with Severe Community-acquired Pneumonia and Association with Disease Severity
作者: Wu, H.P.
Chen, C.K.
Chung, K.
Jiang, B.Y.
Yu, T.J.
Chuang, D.Y.
關鍵字: community-acquired pneumonia
disease severity
transforming growth factor
respiratory-tract infection
consensus conference
myeloid cells-1
organ failure
septic shock
期刊/報告no:: Journal of the Formosan Medical Association, Volume 108, Issue 1, Page(s) 20-27.
摘要: Background/Purpose: Pro- and anti-inflammatory cytokines, such as interferon (IFN)-gamma, interleukin (IL)-6, IL-10, IL-12 and transforming growth factor (TGF)-beta 1, have been shown to be mediators associated with severe community-acquired pneumonia (CAP). It is unknown whether plasma TGF-beta 1 level can help physicians to judge disease severity. In this study, we investigated the value of predicting mortality in patients with severe CAP by the plasma levels of IFN-gamma, IL-6, IL-10, IL-12 and TGF-beta 1 on admission day. Methods: Patients who were admitted to the emergency department and soon transfer-red to the ICU because of severe CAP were enrolled in this study Plasma levels of IFN-gamma, IL-6, IL-10, IL-12 and TGF-beta 1 on the day of admission were determined in 49 survivors and 14 non-survivors within 28 days by ELISA. Clinical characteristics were also recorded. Results: Plasma IL-6, IL-10 and TGF-beta 1 levels on admission were significantly different between survivors and non-survivors. Conversely, there was no significant difference in plasma IFN-gamma and IL-12 levels between the survivors and non-survivors. Furthermore, the plasma TGF-beta 1 level was the only independent factor associated with mortality. The value of predicting mortality in patients with severe CAP was similar for IL-6, IL-10 and TCF-beta 1. Plasma IL-6 level was not related to the Acute Physiology and Chronic Health Evaluation (APACHE) II score. However, plasma IL-10 and TGF-beta 1 levels were correlated with APACHE II score. Conclusion: A severity scoring system, includingTGF-beta 1 level on admission, may be considered as a useful parameter to predict outcomes of patients with severe CAP. [J Formos Med Assoc 20091-108(1):20-27]
ISSN: 0929-6646
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