Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/34676
標題: Highly Efficient Cul-catalyzed N-Arylation of Azaheterocycles with Aryl Iodides Using 1,1,1-Tris(hydroxymethyl)ethane as a Tridentate O-Donor Ligand: A Shorter Route to Toloxatone and Formal Synthesis of Linezolid
作者: Chen, H.H.
陳耀鐘
Huang, H.M.
Chen, S.C.
Chen, Y.J.
關鍵字: Copper
Cross-coupling
N-Arylation
Azaheterocycles
1,1,1-Tris(hydroxymethyl)ethane
nitrogen-containing heterocycles
cross-coupling reactions
c-n
bond
formation
heteroaryl halides
arylboronic acids
mild conditions
copper
imidazoles
3-aryl-2-oxooxazolidines
期刊/報告no:: Journal of the Chinese Chemical Society, Volume 57, Issue 1, Page(s) 14-18.
摘要: An efficient copper-catalyzed N-arylation of azaheterocycles with aryl iodides using 1,1,1-tris(hydroxymethyl)ethane as a tridentates O-donor ligand has been accomplished in good to excellent yields. Moreover, this highly efficient catalyst system has been successfully demonstrated to one-step synthesis of toloxatone and a shorter route to formal synthesis of linezolid in good yields.
URI: http://hdl.handle.net/11455/34676
ISSN: 0009-4536
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