請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/35067
標題: Determination of phthalate esters from food-contacted materials by on-line microdialysis and liquid chromatography
作者: Jen, J.F.
鄭政峰
Liu, T.C.
關鍵字: phthalate esters
endocrine disrupters
microdialysis enrichment
high-performance liquid chromatography
solid-phase microextraction
single-drop microextraction
water samples
electrochemical detection
quantitative detection
mass-spectrometry
extraction
metabolites
quantification
chemicals
期刊/報告no:: Journal of Chromatography A, Volume 1130, Issue 1, Page(s) 28-33.
摘要: Phthalates (endocrine disrupters) released from food-contacted plastics into aqueous solution during microwave conditioning were measured with microdialysis enrichment on-lined high-performance liquid chromatography. The released phthalates in aqueous solution were diffused through a cellular dialysis membrane into the perfusion stream and thus enriched prior to HPLC analysis. Conditions for obtaining optimum enrichment such as the hollow dialysis fiber, flow-rate and polarity modifier in perfusion stream, pH, added-salt and stirring rate in sample solution, as well as chromatographic conditions were investigated. Experimental results indicated that microdialysis enrichment with a 20-cm polysulfone hollow dialysis fiber and heptane as the perfusate at 0.10-mu L/min flow-rate to collect phthalates from aqueous sample in 0.5 M KCl matrix (optional pH) at 250 rpm stirring offered the optimum enriched efficiency. The dimethyl phthalate (DMP), diethyl phthalate (DEP) and dibutyl phthalate (DBP) were well separated within 16 min by a C-18 column and eluted gradient from 40 to 90% aqueous acetonitrile (at pH 6.0) and 1.0 to 1.5 mL/min flow-rate. Detection was carried out with an UV detector at 225 urn. The enrichment factors were 14, 140 and 201 (at 0.10-mu L/min perfusate flow-rate) for DMP, DEP and DBP, respectively, with less than 4% RSD. The proposed method provided a very simple, fast and eco-friendly enriched procedure to determine the extent of phthalates migration from disposable plastic materials into drinking soup. (c) 2006 Elsevier B.V. All rights reserved.
URI: http://hdl.handle.net/11455/35067
ISSN: 0021-9673
文章連結: http://dx.doi.org/10.1016/j.chroma.2006.06.029
顯示於類別:化學系所

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