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|標題:||Poly(L-lactide)-Vitamin E TPGS Nanoparticles Enhanced the Cytotoxicity of Doxorubicin in Drug-Resistant MCF-7 Breast Cancer Cells|
|期刊/報告no：:||Biomacromolecules, Volume 11, Issue 10, Page(s) 2576-2582.|
|摘要:||Multiple drug resistance (MDR) seriously reduces the efficacy of many chemotherapeutic agents for cancer. P-GlyCoprotein, an efflux pump overexpressed on the cell surface, plays an important role in drug resistance. but several surfactants, such as vitamin E TPGS, can inhibit P-glycoprotein. In this study, a polylactide-surfactant block copolymer poly(L-lactide)-vitamin E TPGS (PLA-TPGS) was synthesized using bidentate sulfonamide zinc ethyl complex as an efficient catalyst, and its self-assembled nanoparticles were used as carriers of doxorubicin. We first found that the activity of P-tilycoprotein in drug-resistant breast cancer MCF-7/ADR cells was decreased after incubation with PLA-TPGS nanoparticles. In addition, the nuclear accumulation and cytotoxicily of doxorubicin were significantly increased by encapsulation into the nanoparticle. The enhanced efficacy of the doxorubicin loaded PLA-TPGS nanoparticles may result from the combination of inhibition of efflux and increased entry of doxorubicin into the nucleus in drug-resistant MCF-7/ADR cells. Therefore, this innovative delivery system has potential to act as a nanomedicine for therapy of both drug-sensitive and drug-resistant cancer.|
|Appears in Collections:||化學系所|
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