Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/35136
標題: Expression of short-form oncostatin M receptor as a decoy receptor in lung adenocarcinomas
作者: Chen, D.R.
莊敦堯
Chu, C.Y.
Chen, C.Y.
Yang, H.C.
Chiang, Y.Y.
Lin, T.Y.
Chiang, I.P.
Chuang, D.Y.
Yu, C.C.
Chow, K.C.
周寬基
關鍵字: oncostatin M
oncostatin M receptor
hepatocyte growth factor
lung
adenocarcinoma
interleukin-6
hepatocyte growth-factor
cancer-cells
overexpression
carcinoma
interleukin-6
activation
butyrate
ligand
trail
stage
期刊/報告no:: Journal of Pathology, Volume 215, Issue 3, Page(s) 290-299.
摘要: Oncostatin M (OSM) is a member of the interleukin-6 (IL-6) family of cytokines, and binds to the OSM receptor (OSMR) to inhibit cancer growth. Four forms of OSMR have been identified: leukemia inhibitory factor receptor (LIFR), OSMR beta, short-form OSMR (OSMRs) and soluble OSMR (sOSMR). In this study, we examined the type and expression of OSMR in lung adenocarcinomas (LADCs). Expression of OSMR was determined by reverse transcription-polymerase chain reaction (RT-PCR), immunoblotting, immunohistochemistry and confocal immunofluorescent microscopy (CIM). Our results showed that, among the four forms of OSMR, OSMRs was mainly expressed in LADC, and expression level of OSMRs correlated with patient survival. CIM revealed that OSMRs was localized on the cell membrane of LADC cell lines in vitro. OSMRs acts as a decoy receptor by reducing the inhibitory effect of OSM on cell growth. Decrease in OSMRs expression by siRNA increased cell sensitivity to OSM, and ectopic expression of OSMRs reduced cell sensitivity to OSM. These results suggest that expression of OSMRs, which operates as a decoy receptor for OSM, is correlated with disease progression and adverse prognosis in patients with LADC. Copyright (C) 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
URI: http://hdl.handle.net/11455/35136
ISSN: 0022-3417
文章連結: http://dx.doi.org/10.1002/path.2361
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