Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/35147
標題: Isolation and Cytotoxicity of the Lignanoids from Chamaecyparis formosensis
作者: Chen, T.H.
王升陽
Liau, B.C.
Wang, S.Y.
Jong, T.T.
鍾婷婷
關鍵字: Chamaecyparis formosensis
Cupressaceae
Taiwan red cypress
cytotoxicity
lignans
7,7 '-(S)-dihydrotaiwanin C
constituents
chamaecynone
heartwood
leaves
matsum
期刊/報告no:: Planta Medica, Volume 74, Issue 15, Page(s) 1806-1811.
摘要: In this study, we assessed the antitumor activity of the methanol extract from wood chips of the heartwood of the Taiwan red cypress, Chamaecyparis formosensis Matsumura, which is a precious tree species endemic to Taiwan. A brine shrimp lethality test (BST) indicated that the ethyl acetate (EtOAc)-soluble extract from the MeOH extract was a suitable candidate (LC(50) = 15.36 mu g/mL) for further studies of the antitumor activity of its components. From this EtOAc fraction, we isolated six lignans and two norlignans and tested their cytotoxic activities in vitro against promyelocytic leukemia (HL-60) and hepatoma (Hepa-G2) cell lines. Among these compounds, 7,7' (S)-dihydrotaiwanin C, isolated for the first time from nature, with its single crystal Structure depicted in this study, exhibited significant cytotoxic activity against HL60 cell lines in vitro (IC(50) = 4.03 mu g/mL) after 24 hours.
URI: http://hdl.handle.net/11455/35147
ISSN: 0032-0943
文章連結: http://dx.doi.org/10.1055/s-0028-1088325
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