Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/35154
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dc.contributor.authorChen, K.C.en_US
dc.contributor.author曾志明zh_TW
dc.contributor.authorLiao, C.W.en_US
dc.contributor.authorCheng, F.P.en_US
dc.contributor.authorChou, C.C.en_US
dc.contributor.authorChang, S.C.en_US
dc.contributor.authorWu, J.H.en_US
dc.contributor.authorZen, J.M.en_US
dc.contributor.authorChen, Y.T.en_US
dc.contributor.authorLiao, J.W.en_US
dc.contributor.author廖俊旺zh_TW
dc.contributor.author周濟眾zh_TW
dc.contributor.author張仕杰zh_TW
dc.contributor.author鄭豐邦zh_TW
dc.date2009zh_TW
dc.date.accessioned2014-06-06T07:48:52Z-
dc.date.available2014-06-06T07:48:52Z-
dc.identifier.issn0192-6233zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/35154-
dc.description.abstractOutbreaks of food-associated renal failure in pets occurred in Asia and the United States of America in 2004 and 2007. They were related to the combined intoxication of cyanuric acid and melamine. Our aims were to investigate cyanuric acid and melamine contamination of pet food and to examine subchronic toxicity in rats. Levels of 10%, 20%, 50%, and 50%-100% (w/w) of contaminated pet food were fed to rats for three months. Analytical results revealed that the tainted food contained significant levels of cyanuric acid and melamine in a ratio of 1:6.8. Rats fed the diet of 50%-100% for three months exhibited elevated serum blood urea nitrogen and creatinine, as well as dose-dependent melamine/cyanuric acid crystal-induced nephrotoxicity. The melamine/cyanuric acid crystals of various sizes were mixed with necrotic cell debris and inflammatory cells, accompanied by tubular dilation and interstitial fibrosis. The immunohistochemistry index of proliferative cellular nuclear antigen and osteopontin in the kidney of the 50%-100% group were elevated, indicating regeneration of renal cells and the formation of crystals. In conclusion, the combination ratio of cyanuric acid to melamine and the acidic urine content were two factors that, upon repeated exposure, determined the severity of the nephrotoxicity.en_US
dc.language.isoen_USzh_TW
dc.relationToxicologic Pathologyen_US
dc.relation.ispartofseriesToxicologic Pathology, Volume 37, Issue 7, Page(s) 959-968.en_US
dc.relation.urihttp://dx.doi.org/10.1177/0192623309347910en_US
dc.subjectsubchronic toxicityen_US
dc.subjectcontaminated pet fooden_US
dc.subjectmelamineen_US
dc.subjectcyanuric aciden_US
dc.subjectratsen_US
dc.subjectrenal-failureen_US
dc.subject3 dogsen_US
dc.subjectcatsen_US
dc.subjectnephrotoxicityen_US
dc.subjecttoxicologyen_US
dc.titleEvaluation of Subchronic Toxicity of Pet Food Contaminated with Melamine and Cyanuric Acid in Ratsen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1177/0192623309347910zh_TW
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